We have made strategic changes in our environmental health sciences training program in response to the announced restructuring and redirection of NIEHS training programs. Participating Centers, Institutes, and Schools and the 43 members of the training faculty provide critical resources for cutting edge basic science, clinical research, computational sciences and public health. Environmental health science partnerships have resulted in a very successful NIEHS training program in environmental health sciences and recently in the funding of a NIEHS P30 Center for Environmental Genomics and Integrative Biology (CEGIB). Our renewal proposal incorporates and integrates several new Schools, Centers, and Institutes, including CEGIB, the Clinical and Translational Sciences Institute, and the School of Public Health and Information Sciences. We propose a substantially improved predoctoral and postdoctoral training program that serves as an umbrella for interdisciplinary and integrated approaches to environmental health sciences. The training program will support six predoctoral and three postdoctoral trainees. Initial student recruitment and funding for predoctoral trainees is provided by the University of Louisville Integrated Programs in the Biomedical Sciences recruitment gateway. As in the first cycle, predoctoral trainees will not be recruited directly into the environmental health sciences training program. All faculty mentors are asked to nominate trainees who have completed an approved dissertation proposal with a defined focus in environmental health sciences research. Faculty mentors will be asked to nominate either existing postdoctoral fellows (for example those already matriculated into the Clinical Chemistry and Toxicology Translational Sciences Program) or from trainees to be recruited. Teams of mentors (basic and clinical scientists or basic and population-based scientists) will be particularly encouraged to emphasize the importance of multidisciplinary training and translation of basic science findings to the patient and/or community. Our training program facilitates multi- disciplinary approaches for effective intervention and interfaces exceptionally well with the NIH Roadmap as well as with the strategic plans of NIEHS and the University of Louisville.

Public Health Relevance

(Seeinstructions): The environmental health problems faced by the nation are multi-factorial in nature, and therefore require multi-disciplinary approaches for effective intervention. Our training program emphasizes the importance of multidisciplinary training and translation of basic science findings to benefit the patient and/or community. This multi-disciplinary translational program interfaces with the NIH Roadmap and the NIEHS strategic plan.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Institutional National Research Service Award (T32)
Project #
5T32ES011564-09
Application #
8296295
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Shreffler, Carol K
Project Start
2004-07-01
Project End
2014-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
9
Fiscal Year
2012
Total Cost
$438,569
Indirect Cost
$25,009
Name
University of Louisville
Department
Pharmacology
Type
Schools of Medicine
DUNS #
057588857
City
Louisville
State
KY
Country
United States
Zip Code
40292
Anders, Lisanne C; Yeo, Heegook; Kaelin, Brenna R et al. (2016) Role of dietary fatty acids in liver injury caused by vinyl chloride metabolites in mice. Toxicol Appl Pharmacol 311:34-41
Poole, Lauren G; Arteel, Gavin E (2016) Transitional Remodeling of the Hepatic Extracellular Matrix in Alcohol-Induced Liver Injury. Biomed Res Int 2016:3162670
Cannon, Abigail R; Morris, Niya L; Hammer, Adam M et al. (2016) Alcohol and inflammatory responses: Highlights of the 2015 Alcohol and Immunology Research Interest Group (AIRIG) meeting. Alcohol 54:73-7
Massey, Veronica L; Dolin, Christine E; Poole, Lauren G et al. (2016) The hepatic "matrisome" responds dynamically to injury: Characterization of transitional changes to the extracellular matrix in mice. Hepatology :
Massey, Veronica L; Poole, Lauren G; Siow, Deanna L et al. (2015) Chronic Alcohol Exposure Enhances Lipopolysaccharide-Induced Lung Injury in Mice: Potential Role of Systemic Tumor Necrosis Factor-Alpha. Alcohol Clin Exp Res 39:1978-88
Feng, Lingfang; Zhang, Yue; Jiang, Mizu et al. (2015) Up-regulation of Gadd45α after exposure to metal nanoparticles: the role of hypoxia inducible factor 1α. Environ Toxicol 30:490-9
Becker, Lindsey E; Takwi, Apana Agha L; Lu, Zhongxin et al. (2015) The role of miR-200a in mammalian epithelial cell transformation. Carcinogenesis 36:2-12
Massey, Veronica L; Stocke, Kendall S; Schmidt, Robin H et al. (2015) Oligofructose protects against arsenic-induced liver injury in a model of environment/obesity interaction. Toxicol Appl Pharmacol 284:304-14
Al-Eryani, Laila; Wahlang, Banrida; Falkner, K C et al. (2015) Identification of Environmental Chemicals Associated with the Development of Toxicant-associated Fatty Liver Disease in Rodents. Toxicol Pathol 43:482-97
Russell, Gilandra K; Gupta, Ramesh C; Vadhanam, Manicka V (2015) Effect of phytochemical intervention on dibenzo[a,l]pyrene-induced DNA adduct formation. Mutat Res 774:25-32

Showing the most recent 10 out of 97 publications