The investigators have made strategic changes in their environmental health sciences training program in response to the announced restructuring and redirection of NIEHS training programs. Participating Centers, Institutes, and Schools and the members of the training faculty provide critical resources for cutting edge basic science, clinical research, computational sciences and public health. Environmental health science partnerships have resulted in a very successful NIEHS training program in environmental health sciences. The renewal application incorporates and integrates several Schools, Centers, and Institutes. The investigators propose a substantially improved pre-doctoral and postdoctoral training program that serves as an umbrella for interdisciplinary and integrated approaches to environmental health sciences. The training program will support six pre-doctoral and three postdoctoral trainees. Initial student recruitment and funding for pre-doctoral trainees is provided by the University of Louisville Integrated Programs in the Biomedical Sciences recruitment gateway. As in the first cycle, pre-doctoral trainees will not be recruited directly into the environmental health sciences training program. All faculty mentors are asked to nominate trainees who have completed an approved dissertation proposal with a defined focus in environmental health sciences research. Faculty mentors will be asked to nominate either existing postdoctoral fellows (for example those already matriculated into the Clinical Chemistry and Toxicology Translational Sciences Program) or from trainees to be recruited. Teams of mentors (basic and clinical scientists or basic and population-based scientists) will be particularly encouraged to emphasize the importance of multidisciplinary training and translation of basic science findings to the patient and/or community. The training program facilitates multidisciplinary approaches for effective intervention and interfaces exceptionally well with the NIH Roadmap as well as with the strategic plans of NIEHS and the University of Louisville.

Public Health Relevance

The environmental health problems faced by the nation are multi-factorial in nature, and therefore require multi-disciplinary approaches for effective intervention. The training program emphasizes the importance of multidisciplinary training and translation of basic science findings to benefit the patient and/or community. This multi-disciplinary translational program interfaces with the NIH Roadmap and the NIEHS strategic plan.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Institutional National Research Service Award (T32)
Project #
2T32ES011564-11A1
Application #
9073542
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Shreffler, Carol A
Project Start
2002-07-01
Project End
2021-06-30
Budget Start
2016-07-01
Budget End
2017-06-30
Support Year
11
Fiscal Year
2016
Total Cost
Indirect Cost
Name
University of Louisville
Department
Pharmacology
Type
Schools of Medicine
DUNS #
057588857
City
Louisville
State
KY
Country
United States
Zip Code
40208
Poole, Lauren G; Beier, Juliane I; Torres-Gonzales, Edilson et al. (2018) Chronic + binge alcohol exposure promotes inflammation and alters airway mechanics in the lung. Alcohol :
Stepp, Marcus W; Doll, Mark A; Carlisle, Samantha M et al. (2018) Genetic and small molecule inhibition of arylamine N-acetyltransferase 1 reduces anchorage-independent growth in human breast cancer cell line MDA-MB-231. Mol Carcinog 57:549-558
Liang, Yaqin; Lang, Anna L; Zhang, Jian et al. (2018) Exposure to Vinyl Chloride and Its Influence on Western Diet-Induced Cardiac Remodeling. Chem Res Toxicol 31:482-493
Lang, Anna L; Chen, Liya; Poff, Gavin D et al. (2018) Vinyl chloride dysregulates metabolic homeostasis and enhances diet-induced liver injury in mice. Hepatol Commun 2:270-284
Carlisle, Samantha M; Trainor, Patrick J; Doll, Mark A et al. (2018) Knockout of human arylamine N-acetyltransferase 1 (NAT1) in MDA-MB-231 breast cancer cells leads to increased reserve capacity, maximum mitochondrial capacity, and glycolytic reserve capacity. Mol Carcinog 57:1458-1466
Lang, Anna L; Beier, Juliane I (2018) Interaction of volatile organic compounds and underlying liver disease: a new paradigm for risk. Biol Chem 399:1237-1248
Zhang, Xiaoyan; Carlisle, Samantha M; Doll, Mark A et al. (2018) High N-Acetyltransferase 1 Expression Is Associated with Estrogen Receptor Expression in Breast Tumors, but Is not Under Direct Regulation by Estradiol, 5?-androstane-3?,17?-Diol, or Dihydrotestosterone in Breast Cancer Cells. J Pharmacol Exp Ther 365:84-93
Hudson, Shanice V; Dolin, Christine E; Poole, Lauren G et al. (2017) Modeling the Kinetics of Integrin Receptor Binding to Hepatic Extracellular Matrix Proteins. Sci Rep 7:12444
Massey, Veronica L; Dolin, Christine E; Poole, Lauren G et al. (2017) The hepatic ""matrisome"" responds dynamically to injury: Characterization of transitional changes to the extracellular matrix in mice. Hepatology 65:969-982
Poole, Lauren G; Massey, Veronica L; Siow, Deanna L et al. (2017) Plasminogen Activator Inhibitor-1 Is Critical in Alcohol-Enhanced Acute Lung Injury in Mice. Am J Respir Cell Mol Biol 57:315-323

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