The goal of the Gene-Environment Interactions Training Program (GEITP) is to train pre-doctoral and postdoctoral students who will be versed in ways that both environment exposures and genetic diversity nteract to alter the onset of disease. Achieving this objective requires an interdisciplinary team approach integrating an understanding of genetic diversity, epigenetic alterations, high-throughput genomics, biostatistics, biomarkers, and exposure assessment approaches. The collaborative efforts of research faculty, clinicians, postdoctoral and pre-doctoral trainees are needed in order to meet this objective. A mentorship team approach, combining the expertise of well-regarded scientists in the areas of exposure assessment, genetic variability, biomarkers of disease, and individualized/tailored medicine will be used to educate trainees in multiple areas of gene-environment interactions. Predoctoral training will include required coursework in addition to the student's matriculated Ph.D. program, laboratory rotations with the team of mentors, and hands-on work in several areas of exposure assessment, high-throughput genetic variability measures, and biomarkers or exposure and/or disease. Postdoctoral training will include programs in laboratory and personnel management, pilot grant applications, and an intensive year long grant writing workshop to prepare them for independent research. All trainees will be required to attend "Technologies in genomics, exposure, and biomarkers" workshop, which will be created as part of this program, and present research results at an annual GEITP Student Symposium. This program will include a dedicated governance structure to assure that appropriate trainees are recruited, education goals are met, and the aims of this grant are achieved.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Institutional National Research Service Award (T32)
Project #
3T32ES016646-05S1
Application #
8889398
Study Section
Special Emphasis Panel (ZES1-LWJ-G (TG))
Program Officer
Shreffler, Carol K
Project Start
2008-07-01
Project End
2015-06-30
Budget Start
2014-07-01
Budget End
2015-06-30
Support Year
5
Fiscal Year
2014
Total Cost
$256,447
Indirect Cost
$17,811
Name
University of Cincinnati
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
041064767
City
Cincinnati
State
OH
Country
United States
Zip Code
45221
Gálvez-Peralta, Marina; Wang, Zhifang; Bao, Shengying et al. (2014) Tissue-Specific Induction of Mouse ZIP8 and ZIP14 Divalent Cation/Bicarbonate Symporters by, and Cytokine Response to, Inflammatory Signals. Int J Toxicol 33:246-258
Nebert, Daniel W; Shi, Zhanquan; Galvez-Peralta, Marina et al. (2013) Oral benzo[a]pyrene: understanding pharmacokinetics, detoxication, and consequences--Cyp1 knockout mouse lines as a paradigm. Mol Pharmacol 84:304-13
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Liu, Ming-Jie; Bao, Shengying; Gálvez-Peralta, Marina et al. (2013) ZIP8 regulates host defense through zinc-mediated inhibition of NF-?B. Cell Rep 3:386-400
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Wortham, Brian W; Eppert, Bryan L; Motz, Greg T et al. (2012) NKG2D mediates NK cell hyperresponsiveness and influenza-induced pathologies in a mouse model of chronic obstructive pulmonary disease. J Immunol 188:4468-75
Ovesen, Jerald L; Schnekenburger, Michael; Puga, Alvaro (2011) Aryl hydrocarbon receptor ligands of widely different toxic equivalency factors induce similar histone marks in target gene chromatin. Toxicol Sci 121:123-31

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