This application is the first competing continuation of a T32 Institutional Training Grant in Environmental Health Sciences (EHS) entitled: ?Translational Research Training Program in EHS? (T32-ES019851) at the University of Pennsylvania (Penn). This training grant is the only dedicated mechanism to support formalized EHS research training at the pre- and post-doctoral level at Penn and meets a significant need based on trainee interest in the environment and its health impact and biomedical work force need. The mission of the T32 Training Program is to train the next generation of environmental health scientists in the mechanisms by which environmental exposures cause disease and to translate these findings into effective prevention and treatment and improvements in public health. The training program emphasizes the four pillars of translational research, bench, bedside, community and policy. The research training reflects the translational research themes of Penn's P30 Environmental Health Sciences Core Center, the Center of Excellence in Environmental Toxicology (CEET). These themes have been dictated by the incidence of disease that have environmental etiology that affect the Philadelphia region, the physical location of Penn. Training is provided through course work from the Certificate Program in EHS which includes an optional Community Environmental Health Rotation, by conducting a full-time translational research project co- mentored where possible by a basic-scientist and clinician scientist to generate new knowledge in EHS. The 42 distinguished training grant faculty come from Penn and Children's Hospital of Philadelphia and 14 are clinician scientists. The training grant supports common elements including a research club, a dedicated seminar series, an annual symposium dedicated to a translational research theme and optional externships at US EPA, ATSDR and the Silent Spring Institute for trainees interested in policy and human health assessment. The T32 award currently supports three predoctoral fellows to conduct dissertation research on an EHS topic and four postdoctoral fellows to perform mentored EHS research. Predoctoral trainees are supported for a total of three years (2nd year completion of the Certificate Program in EHS and two years dissertation research) and postdoctoral trainees are supported for up to two years. Trainees will be prepared for a suite of careers in the employment sector e.g. academia (in EHS, Pharmacology and Toxicology), government agencies (e.g. US- EPA, CDC, FDA, NTP, NIEHS); and industry (drug, food, cosmetic and nanotechnology). Fifteen trainees were supported in the first four years of this training program and published 41 papers; all the postdoctoral fellows that have left the program have assumed faculty positions. In the next cycle of funding we request an identical number of predoctoral (3) and postdoctoral slots (4).

Public Health Relevance

This T32 Training Program is dedicated to the training of the next generation of environmental health scientists by emphasizing training in the four pillars of translational research, bench, bedside, community and policy.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Institutional National Research Service Award (T32)
Project #
5T32ES019851-07
Application #
9520093
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Shreffler, Carol A
Project Start
2012-07-01
Project End
2022-06-30
Budget Start
2018-07-01
Budget End
2019-06-30
Support Year
7
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Pharmacology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Guo, Lili; Wang, Qingqing; Weng, Liwei et al. (2018) Liquid Chromatography-High Resolution Mass Spectrometry Analysis of Platelet Frataxin as a Protein Biomarker for the Rare Disease Friedreich's Ataxia. Anal Chem 90:2216-2223
Xin, Frances; Fischer, Erin; Krapp, Christopher et al. (2018) Mice exposed to bisphenol A exhibit depressive-like behavior with neurotransmitter and neuroactive steroid dysfunction. Horm Behav 102:93-104
Mazaleuskaya, Liudmila L; Salamatipour, Ashkan; Sarantopoulou, Dimitra et al. (2018) Analysis of HETEs in human whole blood by chiral UHPLC-ECAPCI/HRMS. J Lipid Res 59:564-575
Murray, Jessica R; Mesaros, Clementina A; Arlt, Volker M et al. (2018) Role of Human Aldo-Keto Reductases in the Metabolic Activation of the Carcinogenic Air Pollutant 3-Nitrobenzanthrone. Chem Res Toxicol 31:1277-1288
Weng, Liwei; Guo, Lili; Vachani, Anil et al. (2018) Quantification of Serum High Mobility Group Box 1 by Liquid Chromatography/High-Resolution Mass Spectrometry: Implications for Its Role in Immunity, Inflammation, and Cancer. Anal Chem 90:7552-7560
Winterbottom, Christopher J; Shah, Rupal J; Patterson, Karen C et al. (2018) Exposure to Ambient Particulate Matter Is Associated With Accelerated Functional Decline in Idiopathic Pulmonary Fibrosis. Chest 153:1221-1228
Guo, Lili; Wang, Qingqing; Weng, Liwei et al. (2018) Characterization of a new N-terminally acetylated extra-mitochondrial isoform of frataxin in human erythrocytes. Sci Rep 8:17043
Lachance, Joseph; Berens, Ali J; Hansen, Matthew E B et al. (2018) Genetic Hitchhiking and Population Bottlenecks Contribute to Prostate Cancer Disparities in Men of African Descent. Cancer Res 78:2432-2443
Haroon, Suraiya; Li, Annie; Weinert, Jaye L et al. (2018) Multiple Molecular Mechanisms Rescue mtDNA Disease in C. elegans. Cell Rep 22:3115-3125
Fritsch, Clark; Gout, Jean-Francois Pierre; Vermulst, Marc (2018) Genome-wide Surveillance of Transcription Errors in Eukaryotic Organisms. J Vis Exp :

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