This application is the first competing continuation of a T32 Institutional Training Grant in Environmental Health Sciences (EHS) entitled: ?Translational Research Training Program in EHS? (T32-ES019851) at the University of Pennsylvania (Penn). This training grant is the only dedicated mechanism to support formalized EHS research training at the pre- and post-doctoral level at Penn and meets a significant need based on trainee interest in the environment and its health impact and biomedical work force need. The mission of the T32 Training Program is to train the next generation of environmental health scientists in the mechanisms by which environmental exposures cause disease and to translate these findings into effective prevention and treatment and improvements in public health. The training program emphasizes the four pillars of translational research, bench, bedside, community and policy. The research training reflects the translational research themes of Penn's P30 Environmental Health Sciences Core Center, the Center of Excellence in Environmental Toxicology (CEET). These themes have been dictated by the incidence of disease that have environmental etiology that affect the Philadelphia region, the physical location of Penn. Training is provided through course work from the Certificate Program in EHS which includes an optional Community Environmental Health Rotation, by conducting a full-time translational research project co- mentored where possible by a basic-scientist and clinician scientist to generate new knowledge in EHS. The 42 distinguished training grant faculty come from Penn and Children's Hospital of Philadelphia and 14 are clinician scientists. The training grant supports common elements including a research club, a dedicated seminar series, an annual symposium dedicated to a translational research theme and optional externships at US EPA, ATSDR and the Silent Spring Institute for trainees interested in policy and human health assessment. The T32 award currently supports three predoctoral fellows to conduct dissertation research on an EHS topic and four postdoctoral fellows to perform mentored EHS research. Predoctoral trainees are supported for a total of three years (2nd year completion of the Certificate Program in EHS and two years dissertation research) and postdoctoral trainees are supported for up to two years. Trainees will be prepared for a suite of careers in the employment sector e.g. academia (in EHS, Pharmacology and Toxicology), government agencies (e.g. US- EPA, CDC, FDA, NTP, NIEHS); and industry (drug, food, cosmetic and nanotechnology). Fifteen trainees were supported in the first four years of this training program and published 41 papers; all the postdoctoral fellows that have left the program have assumed faculty positions. In the next cycle of funding we request an identical number of predoctoral (3) and postdoctoral slots (4).

Public Health Relevance

This T32 Training Program is dedicated to the training of the next generation of environmental health scientists by emphasizing training in the four pillars of translational research, bench, bedside, community and policy.

Agency
National Institute of Health (NIH)
Institute
National Institute of Environmental Health Sciences (NIEHS)
Type
Institutional National Research Service Award (T32)
Project #
5T32ES019851-07
Application #
9520093
Study Section
Environmental Health Sciences Review Committee (EHS)
Program Officer
Shreffler, Carol A
Project Start
2012-07-01
Project End
2022-06-30
Budget Start
2018-07-01
Budget End
2019-06-30
Support Year
7
Fiscal Year
2018
Total Cost
Indirect Cost
Name
University of Pennsylvania
Department
Pharmacology
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Gout, Jean-Francois; Li, Weiyi; Fritsch, Clark et al. (2017) The landscape of transcription errors in eukaryotic cells. Sci Adv 3:e1701484
McKee, Sarah E; Grissom, Nicola M; Herdt, Christopher T et al. (2017) Methyl donor supplementation alters cognitive performance and motivation in female offspring from high-fat diet-fed dams. FASEB J 31:2352-2363
Davis, Kristen C; Raizen, David M (2017) A mechanism for sickness sleep: lessons from invertebrates. J Physiol 595:5415-5424
Susiarjo, Martha; Xin, Frances; Stefaniak, Martha et al. (2017) Bile Acids and Tryptophan Metabolism Are Novel Pathways Involved in Metabolic Abnormalities in BPA-Exposed Pregnant Mice and Male Offspring. Endocrinology 158:2533-2542
Cicchini, Michelle; Buza, Elizabeth L; Sagal, Kyra M et al. (2017) Context-Dependent Effects of Amplified MAPK Signaling during Lung Adenocarcinoma Initiation and Progression. Cell Rep 18:1958-1969
Winterbottom, Christopher J; Shah, Rupal J; Patterson, Karen C et al. (2017) Exposure to Ambient Particulate Matter Is Associated With Accelerated Functional Decline in Idiopathic Pulmonary Fibrosis. Chest :
Bansal, Amita; Rashid, Cetewayo; Xin, Frances et al. (2017) Sex- and Dose-Specific Effects of Maternal Bisphenol A Exposure on Pancreatic Islets of First- and Second-Generation Adult Mice Offspring. Environ Health Perspect 125:097022
Erickson, Michelle A; Jude, Joseph; Zhao, Hengjiang et al. (2017) Serum amyloid A: an ozone-induced circulating factor with potentially important functions in the lung-brain axis. FASEB J 31:3950-3965
Crawford, Nicholas G; Kelly, Derek E; Hansen, Matthew E B et al. (2017) Loci associated with skin pigmentation identified in African populations. Science 358:
Hinderer, Christian; Katz, Nathan; Louboutin, Jean-Pierre et al. (2017) Abnormal polyamine metabolism is unique to the neuropathic forms of MPS: potential for biomarker development and insight into pathogenesis. Hum Mol Genet 26:3837-3849

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