The program trains physician-scientists and post-doctoral PhD scientists in aspects of the pathophysiological processes that occur after traumatic injury and critical illness. Over the past 4 years we have successfully recruited to fill our positions and have addressed a key concern that was raised in our previous competitive renewal regarding diversity in our program. We have paid particular attention to identifying and recruiting strong under-represented minority candidates. Our previous competitive renewal also focused upon the "key initiatives", defined by the leaders at the National Institutes of Health and termed the "NIH Roadmap". This had direct bearing on the structure and direction of this training program. Briefly, the key initiatives or themes are: (1) New Pathways to Discovery, (2) Research Teams of the Future and (3) Reengineering the Clinical Research Enterprise. We propose to continue to educate trainees in established molecular biology techniques and will expand their training to include cutting edge research and analysis (i.e. biomedical computing) techniques. Through collaborations with basic scientists and integration with the available research education programs at the University of Washington, we will expose trainees to broad-based research teams and programs. Trainee education and experience will continue to include concepts of translational research, whereby basic observations will be evaluated as potential diagnostic and therapeutic benefit for critically ill patients. In summary, we aim to prepare a diverse group of interested scientists for academic careers as independent investigators and educators. Through a multidisciplinary and collaborative effort, trainees learn how to identify important research questions, how to design, conduct and analyze experiments that will address these questions and how to translate their findings into clinically relevant interventions.

Public Health Relevance

Trauma remains an important public health problem. Injuries are responsible for a high proportion of deaths in people of all ages and medical care for injury victims is costly. Our training program has successfully educated surgeons, physicians and post-doctoral students in aspects of the applied biology of injury and inflammation. Graduates from our program have demonstrated a commitment to understanding the biology of injury and to the care of critically ill injury victims.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
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Special Emphasis Panel (ZGM1-BRT-5 (PD))
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Somers, Scott D
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University of Washington
Schools of Medicine
United States
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Carter, Damien; Warsen, Adelaide; Mandell, Katherine et al. (2014) Delayed topical p38 MAPK inhibition attenuates full-thickness burn wound inflammatory signaling. J Burn Care Res 35:e83-92
Thompson, Callie M; Holden, Tarah D; Rona, Gail et al. (2014) Toll-like receptor 1 polymorphisms and associated outcomes in sepsis after traumatic injury: a candidate gene association study. Ann Surg 259:179-85
Schaeffer, Valérie; Arbabi, Saman; Garcia, Iris A et al. (2011) Role of the mTOR pathway in LPS-activated monocytes: influence of hypertonic saline. J Surg Res 171:769-76
Hassan, Monique; Pham, Tam N; Cuschieri, Joseph et al. (2011) The association between the transfusion of older blood and outcomes after trauma. Shock 35:3-8
Defawe, Olivier D; Kim, Sarah; Chen, Lihua et al. (2010) VASP phosphorylation at serine239 regulates the effects of NO on smooth muscle cell invasion and contraction of collagen. J Cell Physiol 222:230-7
Cuschieri, Joseph; Bulger, Eileen; Schaeffer, Valerie et al. (2010) Early elevation in random plasma IL-6 after severe injury is associated with development of organ failure. Shock 34:346-51
Muangman, Pornprom; Tamura, Richard N; Muffley, Lara A et al. (2009) Substance P enhances wound closure in nitric oxide synthase knockout mice. J Surg Res 153:201-9
Shalhub, Sherene; Junker, Christopher E; Imahara, Scott D et al. (2009) Variation in the TLR4 gene influences the risk of organ failure and shock posttrauma: a cohort study. J Trauma 66:115-22;discussion 122-3
Shalhub, Sherene; Pham, Tam N; Gibran, Nicole S et al. (2009) Tumor necrosis factor gene variation and the risk of mortality after burn injury: a cohort study. J Burn Care Res 30:105-11
Scott, Jeffrey R; Tamura, Richard N; Muangman, Pornprom et al. (2008) Topical substance P increases inflammatory cell density in genetically diabetic murine wounds. Wound Repair Regen 16:529-33

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