This application requests continuing support for a successful interdisciplinary program in Cellular and Molecular Biology at Washington University in St. Louis. The mission of the program is to provide interdisciplinary training to graduate students from four distinct yet related fields of cell and molecular biology (Developmental Biology, Genetics, Cell Biology, and Microbiology). Our program is highly integrated and introduces students to the core concepts and methods of cell and molecular biology. It has an organizational structure specifically designed to foster student and faculty interactions that span programmatic and departmental boundaries, to maintain effective communication and cooperation among the faculty and steering committees of four individual doctoral programs, and to oversee a centralized admissions process. In this renewal, we are implementing three training grant-specific activities to foster a group identity among training grant-supported students: a student-hosted research seminar, a series of sponsored lunches for first- and second-year students, and a set of first-year student talks. We identify students for support based on eight parameters and support them for their first three years because this is when they are most involved in the unifying didactic components of the program. In addition, by supporting students in their first year, we supplement university funds and are able to matriculate more students than would otherwise be possible. We have successfully continued our efforts at recruiting students from under-represented groups in science and disadvantaged backgrounds, and are expanding these efforts to include students with disabilities. The Cellular and Molecular Biology Training Grant itself serves as a powerful unifying force that interconnects students and faculty from all four programs around the shared responsibility of graduate training. And, our graduate training program seeks to enable our students to pursue careers at the vanguard of scientific research and education by helping them to establish a broad-based scientific foundation of knowledge and network of colleagues as they initiate their scientific career.

Public Health Relevance

Most human diseases arise due to disruptions in basic cellular and molecular processes caused by mutations in one's own DNA or the presence of a pathogen in one's body. Our program trains students in the core concepts and methods of cell and molecular biology, and thus provides them with the knowledge and skills required to identify the molecular basis of, and develop more effective treatments for, human disease.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM007067-39
Application #
8500305
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Gindhart, Joseph G
Project Start
1975-07-01
Project End
2016-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
39
Fiscal Year
2013
Total Cost
$937,746
Indirect Cost
$44,574
Name
Washington University
Department
Genetics
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Cottrell, Kyle A; Szczesny, Pawel; Djuranovic, Sergej (2017) Translation efficiency is a determinant of the magnitude of miRNA-mediated repression. Sci Rep 7:14884
Qiao, Yun; Lipovsky, Catherine; Hicks, Stephanie et al. (2017) Transient Notch Activation Induces Long-Term Gene Expression Changes Leading to Sick Sinus Syndrome in Mice. Circ Res 121:549-563
Gul, Danish; Potter, Robert F; Riaz, Hurmat et al. (2017) Draft Genome Sequence of a Salmonella enterica Serovar Typhi Strain Resistant to Fourth-Generation Cephalosporin and Fluoroquinolone Antibiotics. Genome Announc 5:
Wang, Xuya; Mooradian, Arshag D; Erdmann-Gilmore, Petra et al. (2017) Breast tumors educate the proteome of stromal tissue in an individualized but coordinated manner. Sci Signal 10:
Barnes, Terra D; Rieger, Michael A; Dougherty, Joseph D et al. (2017) Group and Individual Variability in Mouse Pup Isolation Calls Recorded on the Same Day Show Stability. Front Behav Neurosci 11:243
Huang, Yue; Koues, Olivia I; Zhao, Jiang-Yang et al. (2017) cis-Regulatory Circuits Regulating NEK6 Kinase Overexpression in Transformed B Cells Are Super-Enhancer Independent. Cell Rep 18:2918-2931
Park, Jooyoung; Gasparrini, Andrew J; Reck, Margaret R et al. (2017) Plasticity, dynamics, and inhibition of emerging tetracycline resistance enzymes. Nat Chem Biol 13:730-736
Potter, Robert F; D'Souza, Alaric W; Wallace, Meghan A et al. (2017) Draft Genome Sequence of the blaOXA-436- and blaNDM-1-Harboring Shewanella putrefaciens SA70 Isolate. Genome Announc 5:
Kober, Daniel L; Brett, Tom J (2017) TREM2-Ligand Interactions in Health and Disease. J Mol Biol 429:1607-1629
Sanchez, Nicholas E; Harty, Breanne L; O'Reilly-Pol, Thomas et al. (2017) Whole Genome Sequencing-Based Mapping and Candidate Identification of Mutations from Fixed Zebrafish Tissue. G3 (Bethesda) 7:3415-3425

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