The Molecular and Cellular Biology (MCB) training program at The University of Chicago is a long- standing interdisciplinary program that trains graduate students for independent academic and research careers in the biomedical sciences. This application requests support for years 38 through 42. Historically, the MCB program has actively supported 28-30 students for 2-3 years each, with a total of ~50-60 trainees in residence at any given time. Based on the success of our recent efforts to recruit highly qualified training grant-eligible students, 30 slots are requested for the next funding period. Students participating in this program are drawn primarily from four graduate programs: (1) Biochemistry and Molecular Biophysics, (2) Cell and Molecular Biology, (3) Development, Regeneration, and Stem Cell Biology, and (4) Microbiology. The mission of the MCB program is to train students to analyze biological processes using the conceptual and experimental tools of biochemistry and molecular, cellular, and structural biology. This training program is focused around a coherent set of scientific themes, but is intrinsically interdisciplinary in nature. The students take a cor set of courses in molecular biology, cell biology, and macromolecular structure. They subsequently pursue research projects involving a diverse set of model systems and approaches. The scientific interactions among the trainees are extensive, and are promoted by formal mechanisms that include monthly student presentations at the MCB Research in Progress series, meetings with trainee-invited distinguished lecturers, and the annual MCB Minisymposium, as well as the weekly MCB-affiliated Graduate Student Seminar series and the annual Molecular Biosciences retreat. The MCB Director or co-Director meets individually with all trainees in residence on an annual basis, to monitor their academic and research progress and to obtain feedback about the program. Historically, the MCB training program has taken the lead in developing a framework for comprehensive graduate training in the molecular biosciences, and this process is ongoing. For example, the MCB Director and co-Director are pioneering the development of an advanced bioethics course. In the Biological Sciences Division, the MCB training program provides a unique framework for fostering communication and collaboration between researchers who share an interest in approaching biological questions at the molecular and cellular level.

Public Health Relevance

The mission of the MCB program is to train Ph.D. students to analyze biological processes using the conceptual and experimental tools of biochemistry and molecular, cellular, and structural biology. This long-standing interdisciplinary training program prepares graduates for independent academic and research careers in the biomedical sciences.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
2T32GM007183-37
Application #
8267541
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Gindhart, Joseph G
Project Start
1975-07-01
Project End
2017-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
37
Fiscal Year
2012
Total Cost
$893,091
Indirect Cost
$42,451
Name
University of Chicago
Department
Genetics
Type
Schools of Medicine
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
Lin, Jenny; Chew, Justin; Chockanathan, Udaysankar et al. (2014) Mixtures of opposing phosphorylations within hexamers precisely time feedback in the cyanobacterial circadian clock. Proc Natl Acad Sci U S A 111:E3937-45
Chan, Yuen-Ling; Brown, M Scott; Qin, Daoming et al. (2014) The third exon of the budding yeast meiotic recombination gene HOP2 is required for calcium-dependent and recombinase Dmc1-specific stimulation of homologous strand assimilation. J Biol Chem 289:18076-86
Burke, Thomas A; Christensen, Jenna R; Barone, Elisabeth et al. (2014) Homeostatic actin cytoskeleton networks are regulated by assembly factor competition for monomers. Curr Biol 24:579-85
Huang, Hao; Suslov, Nikolai B; Li, Nan-Sheng et al. (2014) A G-quadruplex-containing RNA activates fluorescence in a GFP-like fluorophore. Nat Chem Biol 10:686-91
Hoffmann, Andrew D; Yang, Xinan Holly; Burnicka-Turek, Ozanna et al. (2014) Foxf genes integrate tbx5 and hedgehog pathways in the second heart field for cardiac septation. PLoS Genet 10:e1004604
Li, Mei; Lee, Philbert; Zhang, Yao et al. (2014) X-ray crystallographic and fluorometric analysis of the interactions of rhein to human serum albumin. Chem Biol Drug Des 83:167-73
Bhave, Madhura; Papanikou, Effrosyni; Iyer, Prasanna et al. (2014) Golgi enlargement in Arf-depleted yeast cells is due to altered dynamics of cisternal maturation. J Cell Sci 127:250-7
Jacobs, Anna C; Thompson, Mitchell G; Gebhardt, Michael et al. (2014) Genetic Manipulation of Acinetobacter baumannii. Curr Protoc Microbiol 35:6G.2.1-6G.2.11
Zayner, Josiah P; Sosnick, Tobin R (2014) Factors that control the chemistry of the LOV domain photocycle. PLoS One 9:e87074
Rizk, Rania S; Discipio, Katherine A; Proudfoot, Kathleen G et al. (2014) The kinesin-8 Kip3 scales anaphase spindle length by suppression of midzone microtubule polymerization. J Cell Biol 204:965-75

Showing the most recent 10 out of 195 publications