The Duke University Program in Cell and Molecular Biology (CMB) provides an entry portal for PhD training in biological sciences, with the objective of training students for careers in science-related professions. CMB provides an interdisciplinary core curriculum that exposes students to diverse topics before selecting their final PhD program. Students select the topics of greatest interest in a modular core class format that reduces class size to maximize interaction with faculty instructors. Teaching is largely based on critical reading of primary literature, supplemented by training in various quantitative skills and coaching in the design and presentation of research proposals. The core course is complemented by elective courses in many areas of concentration. The program features a laboratory rotation system that allows students to participate in the research in each of three well-equipped laboratories of their choice before selecting an advisor. Students may apply and be admitted directly to the University Program in Cell and Molecular Biology. Prior to the second year of study at Duke, students choose the program in which they will earn the Ph.D, from among the following: Biochemistry, Biology, Cell Biology, Computational Biology and Bioinformatics, Genetics and Genomics, Immunology, Molecular Cancer Biology, Molecular Genetics and Microbiology, Neurobiology, Pathology, or Pharmacology.

Public Health Relevance

Basic scientific research is the engine of discovery that produces new breakthroughs. This program trains students to perform cutting-edge research in several medically relevant areas.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
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National Institute of General Medical Sciences Initial Review Group (BRT)
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Gindhart, Joseph G
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Duke University
Schools of Medicine
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Zhang, Wenli; Wu, Yufeng; Schnable, James C et al. (2012) High-resolution mapping of open chromatin in the rice genome. Genome Res 22:151-62
Ito, Takahiro; Kwon, Hyog Young; Zimdahl, Bryan et al. (2010) Regulation of myeloid leukaemia by the cell-fate determinant Musashi. Nature 466:765-8
Gabelli, Sandra B; Mandelker, Diana; Schmidt-Kittler, Oleg et al. (2010) Somatic mutations in PI3Kalpha: structural basis for enzyme activation and drug design. Biochim Biophys Acta 1804:533-40
Barb, Adam W; Jiang, Ling; Raetz, Christian R H et al. (2010) Assignment of 1H, 13C and 15N backbone resonances of Escherichia coli LpxC bound to L-161,240. Biomol NMR Assign 4:37-40
Franke, Josef D; Montague, Ruth A; Kiehart, Daniel P (2010) Nonmuscle myosin II is required for cell proliferation, cell sheet adhesion and wing hair morphology during wing morphogenesis. Dev Biol 345:117-32
Mandelker, Diana; Gabelli, Sandra B; Schmidt-Kittler, Oleg et al. (2009) A frequent kinase domain mutation that changes the interaction between PI3Kalpha and the membrane. Proc Natl Acad Sci U S A 106:16996-7001
Barb, Adam W; Leavy, Tanya M; Robins, Lori I et al. (2009) Uridine-based inhibitors as new leads for antibiotics targeting Escherichia coli LpxC. Biochemistry 48:3068-77
Robins, Lori I; Williams, Allison H; Raetz, Christian R H (2009) Structural basis for the sugar nucleotide and acyl-chain selectivity of Leptospira interrogans LpxA. Biochemistry 48:6191-201
Amzel, L Mario; Huang, Chuan-Hsiang; Mandelker, Diana et al. (2008) Structural comparisons of class I phosphoinositide 3-kinases. Nat Rev Cancer 8:665-9
Huang, Chuan-Hsiang; Mandelker, Diana; Gabelli, Sandra B et al. (2008) Insights into the oncogenic effects of PIK3CA mutations from the structure of p110alpha/p85alpha. Cell Cycle 7:1151-6

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