The aim of this program is to educate well-trained scholars with an advanced appreciation of genetic rationales and methods to 1) perform basic and applied biomedical research, 2) provide future educators in this discipline, and 3) fulfill health- related positions, both academic and in industry, requiring a sophisticated understanding of genetics and genomics. The training faculty is comprised of fifty-five distinguished and respected members of the scientific community. Their specific strengths are focused in the areas of: chromosome organization and behavior, gene expression and developmental genetics, genetics of model organisms, population and evolutionary genetics, systems biology, and the genetics of human diseases with special emphasis on genetic alterations in cancer, diabetes, cardiac disorders and asthma. Diverse systems including viruses, bacteria, Arabidopsis, yeast, ciliates, Drosophila, nematodes, zebrafish, mice, humans, and a variety of other plant and animal species. Research is also characterized by the use of interdisciplinary approaches.
The aim of this program is to educate well-trained scholars with an advanced appreciation of genetic rationales and methods to 1) perform basic and applied biomedical research, 2) provide future educators in this discipline, and 3) fulfill health- related positions, both academic and in industry, requiring a sophisticated understanding of genetics and genomics.
|Trizzino, Marco; Park, YoSon; Holsbach-Beltrame, Marcia et al. (2017) Transposable elements are the primary source of novelty in primate gene regulation. Genome Res 27:1623-1633|
|Tung, Po-Yuan; Blischak, John D; Hsiao, Chiaowen Joyce et al. (2017) Batch effects and the effective design of single-cell gene expression studies. Sci Rep 7:39921|
|Siddiq, Mohammad A; Hochberg, Georg Ka; Thornton, Joseph W (2017) Evolution of protein specificity: insights from ancestral protein reconstruction. Curr Opin Struct Biol 47:113-122|
|Koch, Evan; Novembre, John (2017) A Temporal Perspective on the Interplay of Demography and Selection on Deleterious Variation in Humans. G3 (Bethesda) 7:1027-1037|
|Siddiq, Mohammad A; Loehlin, David W; Montooth, Kristi L et al. (2017) Experimental test and refutation of a classic case of molecular adaptation in Drosophila melanogaster. Nat Ecol Evol 1:25|
|Cheng, Jiqiu; Demeulemeester, Jonas; Wedge, David C et al. (2017) Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors. Nat Commun 8:1221|
|Leypunskiy, Eugene; Lin, Jenny; Yoo, Haneul et al. (2017) The cyanobacterial circadian clock follows midday in vivo and in vitro. Elife 6:|
|Igartua, Catherine; Mozaffari, Sahar V; Nicolae, Dan L et al. (2017) Rare non-coding variants are associated with plasma lipid traits in a founder population. Sci Rep 7:16415|
|Montefiori, Lindsey; Hernandez, Liana; Zhang, Zijie et al. (2017) Reducing mitochondrial reads in ATAC-seq using CRISPR/Cas9. Sci Rep 7:2451|
|Sampedro, Georgia R; Bubeck Wardenburg, Juliane (2017) Staphylococcus aureus in the Intensive Care Unit: Are These Golden Grapes Ripe for a New Approach? J Infect Dis 215:S64-S70|
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