This multi-disciplinary Medical Scientist Training Program (MSTP) is designed to provide education for trainees in clinical medicine and biomedical science and has as its goal the training of physician-scientists who, because of their simultaneous and rigorous education, are well-equipped biomedical investigators. The University of California, San Diego (UCSD) is a campus has considerable strength in the biomedical sciences, which is enhanced by the local community and nearby institutions. The strong ties between the School of Medicine (SOM), the adjoining UCSD General Campus and nearby research institutes (e.g., Salk Institute for Biological Studies [Salk], the Scripps Research Institute [TSRI], the Burnham Institute), as well as within the San Diego biomedical community create an academic environment highly suited for this MSTP and for the interdigitation of basic science, biomedical research and medical practice. The education is integrated: in the first two years, trainees take the preclinical SOM curriculum and utilize elective time to explore research opportunities and fulfill academic requirements in Graduate Programs. Students choose a Graduate Program toward the end of the preclinical curriculum. The site of research training depends upon the research area chosen by the student. Graduate training Programs that lead to the PhD degree include Anthropology, Biology, Biomedical Sciences, Bioengineering, Bioinformatics, Biophysics, Chemistry/ Biochemistry, Epidemiology, Neuroscience, Physics, and the TSRI Program in Chemical and Biological Sciences. In recent years most students have chosen the Biomedical Sciences or Neuroscience Graduate Program for their PhD training. Completion of clinical clerkships in the SOM leads to the M.D. degree. Flexibility of curriculum design is stressed and each student's program is individualized. In addition, the MSTP engages in a number of activities designed to enhance combined degree training and a sense of community among trainees embarking on careers as physician scientists. Evidence of the success of this MSTP is indicated by its high percentage of graduates who enter academic medicine and have careers as physician-scientists.

Public Health Relevance

The caliber of students is excellent, with graduates from leading universities throughout the US. Almost all of our graduates since 1990 have continued to pursue research, most in academic positions. This MSTP has grown through expanded research opportunities at UCSD and affiliated institutions, by a growing pool of high quality applicants and faculty and through support from UCSD, Salk and TSRI.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Preusch, Peter C
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California San Diego
Schools of Medicine
La Jolla
United States
Zip Code
Saberi, Shahram; Stauffer, Jennifer E; Jiang, Jie et al. (2018) Sense-encoded poly-GR dipeptide repeat proteins correlate to neurodegeneration and uniquely co-localize with TDP-43 in dendrites of repeat-expanded C9orf72 amyotrophic lateral sclerosis. Acta Neuropathol 135:459-474
Svensson, Kristoffer; Dent, Jess R; Tahvilian, Shahriar et al. (2018) Defining the contribution of skeletal muscle pyruvate dehydrogenase alpha 1 (Pdha1) to exercise performance and insulin action. Am J Physiol Endocrinol Metab :
Linker, Sara B; Hsu, Jonathan Y; Pfaff, Adela et al. (2018) BrainImageR: Spatiotemporal gene set analysis referencing the human brain. Bioinformatics :
Kolar, Matthew J; Nelson, Andrew T; Chang, Tina et al. (2018) Faster Protocol for Endogenous Fatty Acid Esters of Hydroxy Fatty Acid (FAHFA) Measurements. Anal Chem 90:5358-5365
Masutani, Evan M; Contijoch, Francisco; Kyubwa, Espoir et al. (2018) Volumetric segmentation-free method for rapid visualization of vascular wall shear stress using 4D flow MRI. Magn Reson Med 80:748-755
Markmiller, Sebastian; Soltanieh, Sahar; Server, Kari L et al. (2018) Context-Dependent and Disease-Specific Diversity in Protein Interactions within Stress Granules. Cell 172:590-604.e13
Dumdie, Jennifer N; Cho, Kyucheol; Ramaiah, Madhuvanthi et al. (2018) Chromatin Modification and Global Transcriptional Silencing in the Oocyte Mediated by the mRNA Decay Activator ZFP36L2. Dev Cell 44:392-402.e7
Sulli, Gabriele; Rommel, Amy; Wang, Xiaojie et al. (2018) Pharmacological activation of REV-ERBs is lethal in cancer and oncogene-induced senescence. Nature 553:351-355
King, Liam B; West, Brandyn R; Schendel, Sharon L et al. (2018) The structural basis for filovirus neutralization by monoclonal antibodies. Curr Opin Immunol 53:196-202
Tirrell, Timothy F; Rademaker, Alfred W; Lieber, Richard L (2018) Analysis of hierarchical biomechanical data structures using mixed-effects models. J Biomech 69:34-39

Showing the most recent 10 out of 306 publications