The Medical Scientist Training Program at Yale is designed to train physician-scientists who will translate basic and clinical research to problems of human pathobiology. About 12 students each year enter our MSTP and make up -12% of the medical school class. The strength of our Program is the flexibility of the Yale System of medical education and the breadth and depth of the graduate programs at Yale. These programs of medical and graduate education allow MSTP students to customize their educational paths. Graduate training at Yale provide students with opportunities in many biomedical tracks including Cell Biology, Physiology, Genetics, Immunology, Microbiology, Molecular Biophysics &Biochemistry, Neuroscience, Pharmacology, Molecular Cellular &Developmental Biology, and Chemistry. We accommodate students in nontraditional areas such as epidemiology and public health, psychology, computer sciences, sociology and anthropology. New programs in Translational Research (e.g... Clinical Immunology and Cancer Biology), and in Biomedical Engineering provide new opportunities for MSTP students. The Program requires ~8 years to complete but emphasizes interdisciplinary training and correlation with clinical disciplines. Students spend the first two years studying basic sciences of which some courses can be taken for graduate school credit. Clinical medicine is introduced in the 2nd year and emphasizes systems approaches to disease. All students complete 6 months of clerkships in medicine, pads and psychiatry before beginning thesis work. This prepares them for participation in weekly longitudinal clinics in ambulatory medicine, designed for MSTP students during the research years. Students are thus able to relate research training to clinical medicine without compromising lab time. Approximately 74% of our graduates now in academic positions are in clinical departments while 26% are in basic science departments. Our goal of preparing physician-scientists for academic careers has been successful in that -90% of our graduates have peer reviewed research grants. Over the past 36 years the Program has been in existence, >8,000 publications in top journals have appeared.

Public Health Relevance

Basic and translational/clinical research form the basis for all advances in health. We are now at a crossroads in basic science with our understanding of the human genome and our ability to decipher the cellular and molecular basis of normal and pathophysiological processes, and design rational approaches to alleviating disease. The future of medicine depends on the marriage of basic and clinical disciplines: MSTP nhvsician-scienti.sts will lead these endeavors.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM007205-38
Application #
8279190
Study Section
Special Emphasis Panel (ZGM1-BRT-X (TR))
Program Officer
Preusch, Peter C
Project Start
1975-07-01
Project End
2015-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
38
Fiscal Year
2012
Total Cost
$2,234,455
Indirect Cost
$95,515
Name
Yale University
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
043207562
City
New Haven
State
CT
Country
United States
Zip Code
06520
Weinstein, Jason S; Herman, Edward I; Lainez, Begoña et al. (2016) TFH cells progressively differentiate to regulate the germinal center response. Nat Immunol 17:1197-205
Clark, Victoria E; Harmancı, Akdes Serin; Bai, Hanwen et al. (2016) Recurrent somatic mutations in POLR2A define a distinct subset of meningiomas. Nat Genet 48:1253-9
Loeliger, Kelsey B; Niccolai, Linda M; Mtungwa, Lillian N et al. (2016) ""I Have to Push Him with a Wheelbarrow to the Clinic"": Community Health Workers' Roles, Needs, and Strategies to Improve HIV Care in Rural South Africa. AIDS Patient Care STDS 30:385-94
Wickersham, Jeffrey A; Loeliger, Kelsey B; Marcus, Ruthanne et al. (2016) Patterns of substance use and correlates of lifetime and active injection drug use among women in Malaysia. Am J Drug Alcohol Abuse 42:98-110
Clarke, Toni-Kim; Smith, Andrew H; Gelernter, Joel et al. (2016) Polygenic risk for alcohol dependence associates with alcohol consumption, cognitive function and social deprivation in a population-based cohort. Addict Biol 21:469-80
Pirakitikulr, Nathan; Kohlway, Andrew; Lindenbach, Brett D et al. (2016) The Coding Region of the HCV Genome Contains a Network of Regulatory RNA Structures. Mol Cell 62:111-20
Haas, Laura T; Salazar, Santiago V; Kostylev, Mikhail A et al. (2016) Metabotropic glutamate receptor 5 couples cellular prion protein to intracellular signalling in Alzheimer's disease. Brain 139:526-46
Loeliger, Kelsey B; Marcus, Ruthanne; Wickersham, Jeffrey A et al. (2016) The syndemic of HIV, HIV-related risk and multiple co-morbidities among women who use drugs in Malaysia: Important targets for intervention. Addict Behav 53:31-9
Chan, Pamela Y; Carrera Silva, Eugenio A; De Kouchkovsky, Dimitri et al. (2016) The TAM family receptor tyrosine kinase TYRO3 is a negative regulator of type 2 immunity. Science 352:99-103
Yang, Genevieve J; Murray, John D; Wang, Xiao-Jing et al. (2016) Functional hierarchy underlies preferential connectivity disturbances in schizophrenia. Proc Natl Acad Sci U S A 113:E219-28

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