This proposal requests funds to continue, beyond the 32nd year, a program for training Ph.D. candidates in Cellular and Molecular Biology at the New York University School of Medicine. This program involves investigators in five basic science departments as well as Chemistry. Training is offered in the general areas of function and biogenesis of macromolecules and subcellular organelles, as well as the mechanisms that regulate cell metabolism, differentiation and growth, and intercellular interactions during development. Additions to our faculty since the last renewal application add to this program strong representation in several new areas at the cutting edge of Cell and Molecular Biology, including Cellular Immunology, Transcriptional Biology, Chemical Biology, Cellular Pathogenesis, and Disease Mechanisms. The interdisciplinary character of the program allows for a wide perspective for the student in approaching a research project and selecting thesis advisors. The design of the curriculum provides trainees with an advanced, but balanced biological education that prepares them to understand and apply to their research sophisticated ideas and methodologies of biochemistry, genetics, immunology, and molecular cell biology. The increased visibility of the research enterprise at the Medical Center, the addition of new laboratory space as well as a vigorous nationwide recruitment program has more than doubled the number of applicants to the program who are eligible for training grant support in the past decade. The program consists of lecture courses, tutorials, seminars and laboratory research and requires satisfactory performance in an oral qualifying examination. Trainees are selected from an applicant pool which is composed primarily from undergraduates or those recently graduated but employed in a research field. Candidates for admission to are selected by a committee of faculty members of the participating departments and their acceptance must be approved by the Sackler Institute, which administers all graduate programs in the Basic Medical Sciences at the School of Medicine. Students enter an open program and choose their thesis advisors and areas of research at the end of their first year and after completing three apprenticeships in different laboratories. Individual committees of faculty members follow the progress of trainees and mentor them throughout the course of their thesis research. Funds are requested to support five trainees out of a total trainee group of 30-40. Normally, four to five years will be required to obtain the Ph.D. degree. Trainees are prepared to enter fields of the biomedical sciences that have an impact on human health with respect to understanding fundamental mechanisms of Cellular and Molecular Biology as well as understanding the pathological processes such as cancer, atherosclerosis, and neurodegenerative diseases.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
3T32GM007238-38S1
Application #
8678356
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Gindhart, Joseph G
Project Start
2013-09-01
Project End
2015-08-31
Budget Start
2013-09-01
Budget End
2015-08-31
Support Year
38
Fiscal Year
2013
Total Cost
$96,050
Indirect Cost
$4,547
Name
New York University
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
121911077
City
New York
State
NY
Country
United States
Zip Code
10016
Shrestha, Elina; Hussein, Maryem A; Savas, Jeffery N et al. (2016) Poly(ADP-ribose) Polymerase 1 Represses Liver X Receptor-mediated ABCA1 Expression and Cholesterol Efflux in Macrophages. J Biol Chem 291:11172-84
Schafer, Marissa J; Dolgalev, Igor; Alldred, Melissa J et al. (2015) Calorie Restriction Suppresses Age-Dependent Hippocampal Transcriptional Signatures. PLoS One 10:e0133923
Narendra, Varun; Rocha, Pedro P; An, Disi et al. (2015) CTCF establishes discrete functional chromatin domains at the Hox clusters during differentiation. Science 347:1017-21
Schafer, Marissa J; Alldred, Melissa J; Lee, Sang Han et al. (2015) Reduction of β-amyloid and γ-secretase by calorie restriction in female Tg2576 mice. Neurobiol Aging 36:1293-302
Wu, Chaowei; Hussein, Maryem A; Shrestha, Elina et al. (2015) Modulation of Macrophage Gene Expression via Liver X Receptor α Serine 198 Phosphorylation. Mol Cell Biol 35:2024-34
Hussein, Maryem A; Shrestha, Elina; Ouimet, Mireille et al. (2015) LXR-Mediated ABCA1 Expression and Function Are Modulated by High Glucose and PRMT2. PLoS One 10:e0135218
Fennell, Myles; Commisso, Cosimo; Ramirez, Craig et al. (2015) High-content, full genome siRNA screen for regulators of oncogenic HRAS-driven macropinocytosis. Assay Drug Dev Technol 13:347-55
Saldaña-Meyer, Ricardo; González-Buendía, Edgar; Guerrero, Georgina et al. (2014) CTCF regulates the human p53 gene through direct interaction with its natural antisense transcript, Wrap53. Genes Dev 28:723-34
Li, Xuan Shirley; Trojer, Patrick; Matsumura, Tatsushi et al. (2010) Mammalian SWI/SNF--a subunit BAF250/ARID1 is an E3 ubiquitin ligase that targets histone H2B. Mol Cell Biol 30:1673-88
Chiang, Y Jeffrey; Hsiao, Susan J; Yver, Dena et al. (2008) Tankyrase 1 and tankyrase 2 are essential but redundant for mouse embryonic development. PLoS One 3:e2639

Showing the most recent 10 out of 41 publications