Case Western Reserve University School of Medicine (CWRU SOM) has provided outstanding MD/PhD training since 1956. The program has a strong track record with many alumni with distinguished research careers, including two Nobel laureates. The NIH-funded CWRU Medical Scientist Training (MST) program was started in 1975 (T32 GM07250) and has 92 current students. The curriculum integrates scientific and clinical instruction with both PhD and MD course work during the first two years, personalized clinical instruction as well as research during the PhD years, core clinical clerkships, and elective time for research and clinical experiences in the final year. Criteria for acceptance include superior academic performance and evidence of strong commitment and skills for research. Acceptance by the MST program automatically admits a student to the SOM and any MST [program-affiliated PhD program, including 11 graduate programs based in the SOM plus Biomedical Engineering, Mechanical and Aerospace Engineering, Biology and Chemistry. PhD mentors are subjected to rigorous review by the MST program Steering Committee and provide individualized research training. All active mentors have established training records and are well supported by NIH research grants and other funding sources. Research and clinical training occurs at CWRU and affiliated institutions (University Hospitals of Cleveland, Cleveland Clinic Foundation, Metro Health Medical Center and the Louis Stokes Veteran's Administration Medical Center). These sites are well equipped for cutting edge research and state of the art clinical training. All CWRU students receive full financial support for stipend, tuition and health fees for all phases of the program (8 years mean duration), and the program provides laptop computers and travel awards for students to attend national research meetings. Numerous MST program-specific program activities supplement the PhD and MD curricula. The program emphasizes development of leadership skills through student governance, faculty mentoring, and student-led program activities. Relevance: Overall, the program integrates clinical and scientific training of physician scientists in basic biomedical sciences and translational fields;training in these areas can then be applied to a wide range of basic, translational and clinical research. Our mission is to train MD/PhD students for outstanding careers in biomedical research to fill the national need for future physician-scientists.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM007250-37
Application #
8281486
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Preusch, Peter C
Project Start
1975-07-01
Project End
2014-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
37
Fiscal Year
2012
Total Cost
$1,340,673
Indirect Cost
$57,309
Name
Case Western Reserve University
Department
Pathology
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Xie, Qi; Wu, Qiulian; Kim, Leo et al. (2016) RBPJ maintains brain tumor-initiating cells through CDK9-mediated transcriptional elongation. J Clin Invest 126:2757-72
Wang, Chunyu; Zhang, Fan; Jiang, Sirui et al. (2016) Estrogen receptor-α is localized to neurofibrillary tangles in Alzheimer's disease. Sci Rep 6:20352
Mack, Stephen C; Hubert, Christopher G; Miller, Tyler E et al. (2016) An epigenetic gateway to brain tumor cell identity. Nat Neurosci 19:10-9
Russo, Hana M; Rathkey, Joseph; Boyd-Tressler, Andrea et al. (2016) Active Caspase-1 Induces Plasma Membrane Pores That Precede Pyroptotic Lysis and Are Blocked by Lanthanides. J Immunol 197:1353-67
Askew, David; Su, Charles A; Barkauskas, Deborah S et al. (2016) Transient Surface CCR5 Expression by Naive CD8+ T Cells within Inflamed Lymph Nodes Is Dependent on High Endothelial Venule Interaction and Augments Th Cell-Dependent Memory Response. J Immunol 196:3653-64
Correa, Diego; Somoza, Rodrigo A; Lin, Paul et al. (2016) Mesenchymal stem cells regulate melanoma cancer cells extravasation to bone and liver at their perivascular niche. Int J Cancer 138:417-27
Corradin, Olivia; Cohen, Andrea J; Luppino, Jennifer M et al. (2016) Modeling disease risk through analysis of physical interactions between genetic variants within chromatin regulatory circuitry. Nat Genet 48:1313-1320
Whitney, Meredith Sorenson; Shemery, Ashley M; Yaw, Alexandra M et al. (2016) Adult Brain Serotonin Deficiency Causes Hyperactivity, Circadian Disruption, and Elimination of Siestas. J Neurosci 36:9828-42
Robinson, Nathaniel J; Schiemann, William P (2016) Means to the ends: The role of telomeres and telomere processing machinery in metastasis. Biochim Biophys Acta 1866:320-329
Ostrowski, Stephen M; Johnson, Kachael; Siefert, Matthew et al. (2016) Simvastatin inhibits protein isoprenylation in the brain. Neuroscience 329:264-74

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