This is an application for renewal of the Johns Hopkins University School of Medicine Medical Scientist Training Program, now in its 34th year. The Program seeks to train MD-PhD students for positions of leadership in academic medicine and medical research. Since our last submission in 2004, applications have continued to be very high, averaging 534 per year. Interviews are extended to approximately 15% of those applicants who complete the Hopkins secondary application. Applicants invited for interviews have outstanding academic records (mean GPA 3.9), excellent MCAT scores (average total 37), significant laboratory research experience, and high motivation for careers in biomedical research and clinical medicine. Approximately 10-12 students enter the Program annually and on average 10 students receive MSTP awards. The average length of study for the combined degrees is 7.8 years. There are currently 98 students in the Program;81 have MSTP awards and 4 have individual NRSA awards. Currently, 28% of the students are from groups underrepresented in medicine. Students typically complete two years of preclinical medical school courses before enrolling in a graduate program for 3-4 years. Students can select a mentor from a graduate faculty of 996 investigators in 27 graduate programs. During PhD training, students take advanced courses and complete thesis research, publishing an average of 6.2 peer-reviewed papers, before returning to complete the required clinical clerkships and electives. The MSTP Director is a Johns Hopkins faculty member who is also an active investigator. The Director heads a 36-member MD-PhD Committee that admits applicants and formulates policies for the Program. Since the inception of the Program, 286 MD-PhD students have graduated, 216 with MSTP support. Of the 286 graduates, 226 have completed postgraduate training and begun their careers. Of these, 88% are in medical research positions. This includes those in academic medicine (69%), those at research institutes such as the NIH (7%) and those in the pharmaceutical or biotech industries (12%). Thus, the Program is fulfulling its mission.
Progress towards the solution of major public health problems will inevitably require a steady source of well trained new investigators who have the clinical background to appreciate major medical issues and the research skills to tackle them. Over the years, MD-PhD programs have proven to be a highly effective way to train investigators. We seek here funding to continue a highly successful MD-PhD Program at The Johns Hopkins University School of Medicine.
|Bruner, Katherine M; Murray, Alexandra J; Pollack, Ross A et al. (2016) Defective proviruses rapidly accumulate during acute HIV-1 infection. Nat Med 22:1043-9|
|Dick, Ivy E; Limpitikul, Worawan B; Niu, Jacqueline et al. (2016) A rendezvous with the queen of ion channels: Three decades of ion channel research by David T Yue and his Calcium Signals Laboratory. Channels (Austin) 10:20-32|
|Chu, David; Paoletti, Costanza; Gersch, Christina et al. (2016) ESR1 Mutations in Circulating Plasma Tumor DNA from Metastatic Breast Cancer Patients. Clin Cancer Res 22:993-9|
|Ardeljan, Daniel; Taylor, Martin S; Burns, Kathleen H et al. (2016) Meeting Report: The Role of the Mobilome in Cancer. Cancer Res 76:4316-9|
|Lowenthal, Justin; Gerecht, Sharon (2016) Stem cell-derived vasculature: A potent and multidimensional technology for basic research, disease modeling, and tissue engineering. Biochem Biophys Res Commun 473:733-42|
|Teo, W W; Merino, V F; Cho, S et al. (2016) HOXA5 determines cell fate transition and impedes tumor initiation and progression in breast cancer through regulation of E-cadherin and CD24. Oncogene 35:5539-5551|
|Cloutier, J M; Mahadevaiah, S K; ElInati, E et al. (2016) Mammalian meiotic silencing exhibits sexually dimorphic features. Chromosoma 125:215-26|
|Meeks, Lisa M; Herzer, Kurt R (2016) Prevalence of Self-disclosed Disability Among Medical Students in US Allopathic Medical Schools. JAMA 316:2271-2272|
|Hurley, Paula J; Sundi, Debasish; Shinder, Brian et al. (2016) Germline Variants in Asporin Vary by Race, Modulate the Tumor Microenvironment, and Are Differentially Associated with Metastatic Prostate Cancer. Clin Cancer Res 22:448-58|
|Ehmsen, Jeffrey T; Liu, Yong; Wang, Yue et al. (2016) The astrocytic transporter SLC7A10 (Asc-1) mediates glycinergic inhibition of spinal cord motor neurons. Sci Rep 6:35592|
Showing the most recent 10 out of 324 publications