This is an application for renewal of the Johns Hopkins University School of Medicine Medical Scientist Training Program, now in its 34th year. The Program seeks to train MD-PhD students for positions of leadership in academic medicine and medical research. Since our last submission in 2004, applications have continued to be very high, averaging 534 per year. Interviews are extended to approximately 15% of those applicants who complete the Hopkins secondary application. Applicants invited for interviews have outstanding academic records (mean GPA 3.9), excellent MCAT scores (average total 37), significant laboratory research experience, and high motivation for careers in biomedical research and clinical medicine. Approximately 10-12 students enter the Program annually and on average 10 students receive MSTP awards. The average length of study for the combined degrees is 7.8 years. There are currently 98 students in the Program;81 have MSTP awards and 4 have individual NRSA awards. Currently, 28% of the students are from groups underrepresented in medicine. Students typically complete two years of preclinical medical school courses before enrolling in a graduate program for 3-4 years. Students can select a mentor from a graduate faculty of 996 investigators in 27 graduate programs. During PhD training, students take advanced courses and complete thesis research, publishing an average of 6.2 peer-reviewed papers, before returning to complete the required clinical clerkships and electives. The MSTP Director is a Johns Hopkins faculty member who is also an active investigator. The Director heads a 36-member MD-PhD Committee that admits applicants and formulates policies for the Program. Since the inception of the Program, 286 MD-PhD students have graduated, 216 with MSTP support. Of the 286 graduates, 226 have completed postgraduate training and begun their careers. Of these, 88% are in medical research positions. This includes those in academic medicine (69%), those at research institutes such as the NIH (7%) and those in the pharmaceutical or biotech industries (12%). Thus, the Program is fulfulling its mission.

Public Health Relevance

Progress towards the solution of major public health problems will inevitably require a steady source of well trained new investigators who have the clinical background to appreciate major medical issues and the research skills to tackle them. Over the years, MD-PhD programs have proven to be a highly effective way to train investigators. We seek here funding to continue a highly successful MD-PhD Program at The Johns Hopkins University School of Medicine.

Agency
National Institute of Health (NIH)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM007309-40
Application #
8687661
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Preusch, Peter
Project Start
Project End
Budget Start
Budget End
Support Year
40
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Reid, Branden; Gibson, Matthew; Singh, Anirudha et al. (2015) PEG hydrogel degradation and the role of the surrounding tissue environment. J Tissue Eng Regen Med 9:315-8
Fofana, Mariam O; Knight, Gwenan M; Gomez, Gabriela B et al. (2014) Population-level impact of shorter-course regimens for tuberculosis: a model-based analysis. PLoS One 9:e96389
van Schalkwyk, Cari; Variava, Ebrahim; Shapiro, Adrienne E et al. (2014) Incidence of TB and HIV in prospectively followed household contacts of TB index patients in South Africa. PLoS One 9:e95372
Perica, Karlo; De Leon Medero, Andres; Durai, Malarvizhi et al. (2014) Nanoscale artificial antigen presenting cells for T cell immunotherapy. Nanomedicine 10:119-29
Xu, Risheng; Bydon, Mohamad; Macki, Mohamed et al. (2014) Adjacent segment disease after anterior cervical discectomy and fusion: clinical outcomes after first repeat surgery versus second repeat surgery. Spine (Phila Pa 1976) 39:120-6
Cottrell, Tricia R; Wise, Robert A; Wigley, Fredrick M et al. (2014) The degree of skin involvement identifies distinct lung disease outcomes and survival in systemic sclerosis. Ann Rheum Dis 73:1060-6
Beaver, Julia A; Jelovac, Danijela; Balukrishna, Sasidharan et al. (2014) Detection of cancer DNA in plasma of patients with early-stage breast cancer. Clin Cancer Res 20:2643-50
Herzer, Kurt R; Pronovost, Peter J (2014) Motivating physicians to improve quality: light the intrinsic fire. Am J Med Qual 29:451-3
Yang, Xiaochuan; Sexauer, Amy; Levis, Mark (2014) Bone marrow stroma-mediated resistance to FLT3 inhibitors in FLT3-ITD AML is mediated by persistent activation of extracellular regulated kinase. Br J Haematol 164:61-72
Chivukula, Raghu R; Shi, Guanglu; Acharya, Asha et al. (2014) An essential mesenchymal function for miR-143/145 in intestinal epithelial regeneration. Cell 157:1104-16

Showing the most recent 10 out of 141 publications