The Cellular and Molecular Biology (CMB) Graduate Program has been a free-standing PhD-granting program at the University of Michigan for almost thirty-five years.
The aim of this Program is to train students with a broad perspective in cellular and molecular biosciences. It is one of the most popular graduate programs in biomedical sciences at Michigan, and during the past 5 years, 81 new students entered the Program and 69 others received PhD's. The University-wide CMB Program draws on faculty, courses and research facilities from 20 departments in the Schools of Medicine, Dentistry, Engineering and the College of Literature Sciences and the Arts. This diversity of expertise and opportunity allows students the broadest possible choice in terms of both elective coursework and strong research training environments. At the same time, students in the Program share a core of common training experiences through a flexible program of required and elective coursework, a strong student seminar program, student-organized short courses, an annual symposium and poster session, an annual retreat, social events and service to the Program. CMB events provide cohesiveness for the Program and contribute to the intellectual environment of the University as highly regarded and well-attended scientific activities. Research programs in the laboratories of the 151 faculty members in CMB cover a wide range of disciplines, including: genetics, genomics, gene regulation;cell biology, biochemistry, physiology and structure;microbial pathogenesis and immunology;developmental biology, neurobiology, aging;molecular mechanisms and genetics of disease. The CMB Program is the only entity at the University that provides training in such diverse problems and perspectives, encouraging interdisciplinary approaches to both basic and translational biomedical research. The continuing growth of the CMB Program reflects increasing interest in its interdisciplinary approach, and highlights its unique role in the context of the Program in Biomedical Sciences at the University. This proposal requests support for 20 trainees, with the aim of supporting 10 students per year for two years. The current goal is to maintain the vitality of the CMB Program while retaining the high quality and individualized training for which CMB is known, and to train leaders of the next generation of biomedical researchers.

Public Health Relevance

The research performed by students in the CMB Program directly addresses problems in both fundamental and clinical sciences that have important implications for a broad array of public health problems, including cancer, chronic (e.g. diabetes, rheumatoid arthritis), infectious (e.g. AIDS, mycobacterial) and neurodegenerative (e.g. Parkinson's, Alzheimer's) diseases. Further, training students who apply cellular and molecular approaches to a wide variety of scientific disciplines continues to add to the population of outstanding scientists in academic and applied research whose work advances knowledge in a wide range of areas important for human health.

Agency
National Institute of Health (NIH)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM007315-38
Application #
8691826
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Gindhart, Joseph G
Project Start
Project End
Budget Start
Budget End
Support Year
38
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Biochemistry
Type
Schools of Medicine
DUNS #
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Lane, Jamie; Kaartinen, Vesa (2014) Signaling networks in palate development. Wiley Interdiscip Rev Syst Biol Med 6:271-8
Yau, Richard G; Peng, Yutian; Valiathan, Rajeshwari R et al. (2014) Release from myosin V via regulated recruitment of an E3 ubiquitin ligase controls organelle localization. Dev Cell 28:520-33
Walczak, Christopher Paul; Ravindran, Madhu Sudhan; Inoue, Takamasa et al. (2014) A cytosolic chaperone complexes with dynamic membrane J-proteins and mobilizes a nonenveloped virus out of the endoplasmic reticulum. PLoS Pathog 10:e1004007
Zhang, Ao; Dong, Beihua; Doucet, Aurelien J et al. (2014) RNase L restricts the mobility of engineered retrotransposons in cultured human cells. Nucleic Acids Res 42:3803-20
Collins, Meredith A; Yan, Wei; Sebolt-Leopold, Judith S et al. (2014) MAPK signaling is required for dedifferentiation of acinar cells and development of pancreatic intraepithelial neoplasia in mice. Gastroenterology 146:822-834.e7
Tan, Minjia; Peng, Chao; Anderson, Kristin A et al. (2014) Lysine glutarylation is a protein posttranslational modification regulated by SIRT5. Cell Metab 19:605-17
Gray, Michael J; Wholey, Wei-Yun; Wagner, Nico O et al. (2014) Polyphosphate is a primordial chaperone. Mol Cell 53:689-99
Lin, Grace; LaPensee, Christopher R; Qin, Zhaohui S et al. (2014) Reciprocal occupancy of BCL6 and STAT5 on Growth Hormone target genes: contrasting transcriptional outcomes and promoter-specific roles of p300 and HDAC3. Mol Cell Endocrinol 395:19-31
Adams, Elizabeth J; Chen, Xiao-Wei; O'Shea, K Sue et al. (2014) Mammalian COPII coat component SEC24C is required for embryonic development in mice. J Biol Chem 289:20858-70
Thomas, Penny S; Rajderkar, Sudha; Lane, Jamie et al. (2014) AcvR1-mediated BMP signaling in second heart field is required for arterial pole development: implications for myocardial differentiation and regional identity. Dev Biol 390:191-207

Showing the most recent 10 out of 119 publications