This is a proposal for the continued training of predoctoral graduate students in the area of molecular and cell biology. The overall guiding principle is to support students from'Training Grant funds who are the most talented and productive. Our objective is to develop their skills as researchers in the general area of cell biology, but we aim to train them more broadly in all aspects of doing research ( seminars, writing grants) so that they will go on to be successful in the academy or in research institutions. The program is comprised of 45 Trainer-directed research programs and 15 Trainee positions for graduate students, who will do their dissertation research in the Trainer labs. The graduate students are recruited primarily from four graduate programs (known as Graduate Groups), namely Biochemistry &Molecular Biology, Cell &Developmental Biology, Genetics and Microbiology, and are generally appointed to the Training Grant after their second year in the graduate program. The program is administered by a nine- person Executive Committee, including a student member. The Training faculty will provide research guidance and mentoring in their labs, will be actively involved in recruiting graduate students to the Davis campus, and will offer courses in molecular and cell biology. In the last five years, the Training faculty have placed particular emphasis on the recruitment of under-represented minority students to our program. Currently there is (andwill be) a highly successful training program external seminar series in which extramural speakers are selected and hosted by the Trainees;an Annual Research Retreat, which is held at Lake Tahoe and serves as a forum for presentation of research seminars by students, postdocs and faculty;brown-bag lunches for the Trainees with the Executive Committee to present and discuss their research;a required course in the responsible conduct of research;and quarterly workshops for all current and past trainees in various areas of career development, such as instruction in grant writing.

Public Health Relevance

All of our students will be working in labs where fundamental cellularprocesses are studied at the molecular level, and where the ultimate goal is to understand these processes in the context of human disease. All trainees will take a course in translational research being developed in collaboration with two other training grants on campus in translational research.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
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National Institute of General Medical Sciences Initial Review Group (BRT)
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Gindhart, Joseph G
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University of California Davis
Anatomy/Cell Biology
Schools of Medicine
United States
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Sepela, Rebecka J; Sack, Jon T (2018) Taming unruly chloride channel inhibitors with rational design. Proc Natl Acad Sci U S A 115:5311-5313
Owens, Shannon; Tang, Shangming; Hunter, Neil (2018) Monitoring Recombination During Meiosis in Budding Yeast. Methods Enzymol 601:275-307
Matt, Lucas; Kirk, Lyndsey M; Chenaux, George et al. (2018) SynDIG4/Prrt1 Is Required for Excitatory Synapse Development and Plasticity Underlying Cognitive Function. Cell Rep 22:2246-2253
Kirmiz, Michael; Palacio, Stephanie; Thapa, Parashar et al. (2018) Remodeling neuronal ER-PM junctions is a conserved nonconducting function of Kv2 plasma membrane ion channels. Mol Biol Cell 29:2410-2432
Coulson, Rochelle L; Yasui, Dag H; Dunaway, Keith W et al. (2018) Snord116-dependent diurnal rhythm of DNA methylation in mouse cortex. Nat Commun 9:1616
Lal, Neeraj K; Nagalakshmi, Ugrappa; Hurlburt, Nicholas K et al. (2018) The Receptor-like Cytoplasmic Kinase BIK1 Localizes to the Nucleus and Regulates Defense Hormone Expression during Plant Innate Immunity. Cell Host Microbe 23:485-497.e5
Bishop, Hannah I; Cobb, Melanie M; Kirmiz, Michael et al. (2018) Kv2 Ion Channels Determine the Expression and Localization of the Associated AMIGO-1 Cell Adhesion Molecule in Adult Brain Neurons. Front Mol Neurosci 11:1
Bell, George R R; Collins, Sean R (2018) ""Rho""ing a Cellular Boat with Rearward Membrane Flow. Dev Cell 46:1-3
Huising, Mark O; Lee, Sharon; van der Meulen, Talitha (2018) Evidence for a Neogenic Niche at the Periphery of Pancreatic Islets. Bioessays 40:e1800119
Blain-Hartung, Matthew; Rockwell, Nathan C; Moreno, Marcus V et al. (2018) Cyanobacteriochrome-based photoswitchable adenylyl cyclases (cPACs) for broad spectrum light regulation of cAMP levels in cells. J Biol Chem 293:8473-8483

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