The Predoctoral Genetics Training Program (GTP) is an interdisciplinary program that provides enriched genetics education for students receiving their Ph.D. degrees in six departments: Biological Chemistry, Ecology and Evolutionary biology (EEB), Human Genetics, Microbiology and Immunology, Molecular, Cellular and Developmental Biology (MCDB) and Pharmacology. Our goal is to train investigators who can apply disciplinary expertise to the new research opportunities of the genomic era. The GTP includes 62 faculty members and 21 trainees. During the current funding period, 38 students received the Ph.D. degree and the curriculum was updated to include training in computational biology and quantitative data analysis. Ongoing research projects range from microbial and viral gene regulation to yeast, plant, fly, mouse and human genetics, and functional genomics. Students are usually supported for their second and third years of graduate study. Most of our graduate students have gone on to productive research careers in academia and industry. Trainees benefit from a University environment that is strongly oriented towards graduate education, with a large and interactive research community that is among the top ten in NIH funding. University-supported core laboratories facilitate trainees'research by providing access to state-of -the-art technology including transgenic models, DNA sequencing, genotyping, and large-scale gene expression. The curriculum includes formal coursework in genetics and interactive seminars. Each year, trainees select four outstanding geneticists from outside the University to lecture on an area of interest. Our annual retreat features an invited keynote speaker and oral and poster presentations by current and former trainees. The GTP, one of the oldest NIH-supported training programs, continues to be a vital component of graduate education and biomedical research at the University of Michigan.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM007544-35
Application #
8293219
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Haynes, Susan R
Project Start
1978-07-01
Project End
2013-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
35
Fiscal Year
2012
Total Cost
$477,710
Indirect Cost
$25,471
Name
University of Michigan Ann Arbor
Department
Genetics
Type
Schools of Medicine
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Wilson, Thomas E; Arlt, Martin F; Park, So Hae et al. (2015) Large transcription units unify copy number variants and common fragile sites arising under replication stress. Genome Res 25:189-200
Schroeder, Jeremy W; Randall, Justin R; Matthews, Lindsay A et al. (2015) Ribonucleotides in bacterial DNA. Crit Rev Biochem Mol Biol 50:181-93
Bronner, Denise N; O'Riordan, Mary Xd (2014) A near death experience: Shigella manipulates host death machinery to silence innate immunity. EMBO J 33:2137-9
Veloso, Artur; Kirkconnell, Killeen S; Magnuson, Brian et al. (2014) Rate of elongation by RNA polymerase II is associated with specific gene features and epigenetic modifications. Genome Res 24:896-905
Walsh, Brian W; Bolz, Samantha A; Wessel, Sarah R et al. (2014) RecD2 helicase limits replication fork stress in Bacillus subtilis. J Bacteriol 196:1359-68
Pai, Dave A; Kaplan, Craig D; Kweon, Hye Kyong et al. (2014) RNAs nonspecifically inhibit RNA polymerase II by preventing binding to the DNA template. RNA 20:644-55
Hrit, Joel; Raynard, Nathan; Van Etten, Jamie et al. (2014) In vitro analysis of RNA degradation catalyzed by deadenylase enzymes. Methods Mol Biol 1125:325-39
Lenhart, Justin S; Brandes, Eileen R; Schroeder, Jeremy W et al. (2014) RecO and RecR are necessary for RecA loading in response to DNA damage and replication fork stress. J Bacteriol 196:2851-60
Maclary, Emily; Buttigieg, Emily; Hinten, Michael et al. (2014) Differentiation-dependent requirement of Tsix long non-coding RNA in imprinted X-chromosome inactivation. Nat Commun 5:4209
de Kovel, Carolien G F; Meisler, Miriam H; Brilstra, Eva H et al. (2014) Characterization of a de novo SCN8A mutation in a patient with epileptic encephalopathy. Epilepsy Res 108:1511-8

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