The primary objective of this Pharmacological Sciences Training Grant is to develop scientists, equipped with the necessary background in the biological and chemical sciences and training in the application of modern tools of research and instrumental techniques, to undertake and direct fundamental research related to drug action, metabolism and kinetics. Trainees follow tracks that emphasize training in four broadly defined areas: (I) drug metabolism, (II) pharmacokinetics, drug transport and delivery, (III) cellular and molecular pharmacology and (IV) structure and drug design, that presently exist in the departments of Medicinal Chemistry, Pharmaceutics and Pharmacology. Didactic components involve individualized, highly multidisciplinary programs of coursework and seminars which center on the biological and chemical sciences. Research components of the program emphasize training in mechanistic and bioanalytical aspects of drug metabolism and toxicology, pharmacokinetics and pharmacodynamics, drug transporter function and regulation, pharmacogenetics, mechanisms and regulation of cell signaling, neuropharmacology and X-ray, NMR and proteomic approaches to structure elucidation of protein-ligand interactions of pharmacological interest. In this competitive renewal of the Pharmacological Sciences National Research Service Award program, support is requested for 16 predoctoral trainees in the first year increasing to 17 and 18 trainees, in the second and fourth years, respectively. The selection of trainees will be on a competitive basis primarily among second year or more advanced graduate students who are committed to research in one of the aforementioned areas.
The training that is provided relates to how drugs used to treat human diseases and other disorders act on the body (pharmacology), and how the body acts on drugs (metabolism and pharmacokinetics). These fundamental areas of knowledge are critical to optimizing the use of drugs already on the market as well as ongoing national and international efforts to discover and develop new therapeutic agents.
|Goulet, Dennis R; Zwolak, Adam; Chiu, Mark L et al. (2017) Diffusion of Soluble Aggregates of THIOMABs and Bispecific Antibodies in Serum. Biochemistry 56:2251-2260|
|Wagner, David J; Duan, Haichuan; Chapron, Alenka et al. (2017) Potent inhibition of human organic cation transporter 2 (hOCT2) by ?-carboline alkaloids. Xenobiotica 47:1112-1120|
|Amory, J K; Ostrowski, K A; Gannon, J R et al. (2017) Isotretinoin administration improves sperm production in men with infertility from oligoasthenozoospermia: a pilot study. Andrology 5:1115-1123|
|Jimenez-Caliani, Antonio J; Pillich, Rudolf; Yang, Wendy et al. (2017) ?E-Catenin Is a Positive Regulator of Pancreatic Islet Cell Lineage Differentiation. Cell Rep 20:1295-1306|
|Bergagnini-Kolev, Mackenzie C; Hebert, Mary F; Easterling, Thomas R et al. (2017) Pregnancy Increases the Renal Secretion of N1-methylnicotinamide, an Endogenous Probe for Renal Cation Transporters, in Patients Prescribed Metformin. Drug Metab Dispos 45:325-329|
|Hsu, Mei-Hui; Baer, Brian R; Rettie, Allan E et al. (2017) The Crystal Structure of Cytochrome P450 4B1 (CYP4B1) Monooxygenase Complexed with Octane Discloses Several Structural Adaptations for ?-Hydroxylation. J Biol Chem 292:5610-5621|
|Wagner, David J; Sager, Jennifer E; Duan, Haichuan et al. (2017) Interaction and Transport of Methamphetamine and its Primary Metabolites by Organic Cation and Multidrug and Toxin Extrusion Transporters. Drug Metab Dispos 45:770-778|
|Plotnik, David; Guo, Wenjin; Cleveland, Brad et al. (2017) Extracellular Matrix Proteins Mediate HIV-1 gp120 Interactions with ?4?7. J Virol 91:|
|Gao, Chunying; Bergagnini-Kolev, Mackenzie C; Liao, Michael Z et al. (2017) Simultaneous quantification of 25-hydroxyvitamin D3-3-sulfate and 25-hydroxyvitamin D3-3-glucuronide in human serum and plasma using liquid chromatography-tandem mass spectrometry coupled with DAPTAD-derivatization. J Chromatogr B Analyt Technol Biomed Life Sci 1060:158-165|
|Krogstad, Emily A; Ramanathan, Renuka; Nhan, Christina et al. (2017) Nanoparticle-releasing nanofiber composites for enhanced in vivo vaginal retention. Biomaterials 144:1-16|
Showing the most recent 10 out of 135 publications