The aim of this predoctoral training program in Cell Biology, Genetics, and Biochemistry is to train scientists to carry out the biomedical research of the future. We equip trainees with an integrated perspective on biological problems as well as broad expertise in a variety of experimental approaches. This training program brings together 95 faculty who are studying central problems in cell biology, genetics, and biochemistry, including regulation of the cell division cycle, signal transduction, chromosome structure, protein trafficking, cytoskeletal organization, protein and nucleic acid folding and structure, DNA replication, RNA splicing, transcriptional control, infectious disease, and various problems in molecular evolution. These studies use the tools of cell biology, genetics and biochemistry to exploit a wide range of systems, including bacteria, yeast, nematodes, zebrafish, Drosophila and humans. The goals of the combined program are accomplished through coursework, Ph.D. thesis research, and a variety of other activities. The features of our training program that are especially attractive to incoming students are: (a) a large number of active, excellent laboratories from which students can choose for their thesis research; (b) a laboratory rotation system that provides meaningful research experience in at least three different laboratories; (c) an excellent set of courses that enables students with little prior training in cell biology, genetics, or biochemistry to acquire a solid foundation in these areas; (d) one-on-one training with faculty members to sharpen public presentation skills; (e) a highly collegial, interactive, and collaborative atmosphere; (f) a high faculty to student ratio; and (g) the high level of importance placed by the UCSF faculty on training graduate students.

Public Health Relevance

Two aspects of the training program are relevant to public health. First, by exposing students to first rate research in many different areas and disciplines, students acquire the expertise and confidence to carry on in a variety of capacities, not limited to those of the research lab or lecture hall. Students who have graduated from the program not only populate many departments throughout the country, but also participate in a variety of public policy roles related to public health. Second, all of the research projects have the potential to improve the understanding and treatment of human health problems, ranging from cancer to aging.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM007810-36
Application #
8882430
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Haynes, Susan R
Project Start
1979-07-01
Project End
2016-06-30
Budget Start
2015-07-01
Budget End
2016-06-30
Support Year
36
Fiscal Year
2015
Total Cost
Indirect Cost
Name
University of California San Francisco
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94118
Laurie, Matthew T; White, Corin V; Retallack, Hanna et al. (2018) Functional Assessment of 2,177 U.S. and International Drugs Identifies the Quinoline Nitroxoline as a Potent Amoebicidal Agent against the Pathogen Balamuthia mandrillaris. MBio 9:
Faust, Tyler B; Li, Yang; Bacon, Curtis W et al. (2018) The HIV-1 Tat protein recruits a ubiquitin ligase to reorganize the 7SK snRNP for transcriptional activation. Elife 7:
Zhou, Coral Y; Johnson, Stephanie L; Lee, Laura J et al. (2018) The Yeast INO80 Complex Operates as a Tunable DNA Length-Sensitive Switch to Regulate Nucleosome Sliding. Mol Cell 69:677-688.e9
Hrit, Joel; Goodrich, Leeanne; Li, Cheng et al. (2018) OGT binds a conserved C-terminal domain of TET1 to regulate TET1 activity and function in development. Elife 7:
Genuth, Miriam A; Allen, Christopher D C; Mikawa, Takashi et al. (2018) Chick cranial neural crest cells use progressive polarity refinement, not contact inhibition of locomotion, to guide their migration. Dev Biol :
Seller, Charles A; O'Farrell, Patrick H (2018) Rif1 prolongs the embryonic S phase at the Drosophila mid-blastula transition. PLoS Biol 16:e2005687
Elnatan, Daniel; Agard, David A (2018) Calcium binding to a remote site can replace magnesium as cofactor for mitochondrial Hsp90 (TRAP1) ATPase activity. J Biol Chem 293:13717-13724
Burke, Jordan E; Longhurst, Adam D; Merkurjev, Daria et al. (2018) Spliceosome Profiling Visualizes Operations of a Dynamic RNP at Nucleotide Resolution. Cell 173:1014-1030.e17
Liang, Samantha I; van Lengerich, Bettina; Eichel, Kelsie et al. (2018) Phosphorylated EGFR Dimers Are Not Sufficient to Activate Ras. Cell Rep 22:2593-2600
Borges, Adair L; Zhang, Jenny Y; Rollins, MaryClare F et al. (2018) Bacteriophage Cooperation Suppresses CRISPR-Cas3 and Cas9 Immunity. Cell 174:917-925.e10

Showing the most recent 10 out of 102 publications