The goal of this training program is to produce students with a broad multi-disciplinary background that enables them to use a variety of approaches to solve important problems in the field of neurobiology. To this end, students complete courses that span neurobiology from the neuroanatomical, neurophysiological, and developmental to the cellular, molecular and behavioral. Formal course work is augmented by weekly seminars, journal clubs, and ah annual retreat. A group of 48 trainers provide excellent opportunities for students to pursue their diverse research interests with experienced and skilled mentors. Since our last submission, the number of applicants to-Neurobiology has doubled an increase that has not been reflected in the number of training grant slots. We are therefore requesting that the number of positions on this training grant be increased to 12, to keep up with our recent and projected growth.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
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National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Maas, Stefan
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University of Chicago
Schools of Medicine
United States
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Pusic, Aya D; Kraig, Richard P (2014) Youth and environmental enrichment generate serum exosomes containing miR-219 that promote CNS myelination. Glia 62:284-99
Runfeldt, Melissa J; Sadovsky, Alexander J; MacLean, Jason N (2014) Acetylcholine functionally reorganizes neocortical microcircuits. J Neurophysiol 112:1205-16
Pusic, Aya D; Pusic, Kae M; Clayton, Benjamin L L et al. (2014) IFNýý-stimulated dendritic cell exosomes as a potential therapeutic for remyelination. J Neuroimmunol 266:12-23
Buggia-Prévot, Virginie; Fernandez, Celia G; Riordan, Sean et al. (2014) Axonal BACE1 dynamics and targeting in hippocampal neurons: a role for Rab11 GTPase. Mol Neurodegener 9:1
Sadovsky, Alexander J; MacLean, Jason N (2014) Mouse visual neocortex supports multiple stereotyped patterns of microcircuit activity. J Neurosci 34:7769-77
Gururangan, Suchin S; Sadovsky, Alexander J; MacLean, Jason N (2014) Analysis of graph invariants in functional neocortical circuitry reveals generalized features common to three areas of sensory cortex. PLoS Comput Biol 10:e1003710
Woehrle, Nancy S; Klenotich, Stephanie J; Jamnia, Naseem et al. (2013) Effects of chronic fluoxetine treatment on serotonin 1B receptor-induced deficits in delayed alternation. Psychopharmacology (Berl) 227:545-51
Farmer, Laurel M; Le, Brandy N; Nelson, Deborah J (2013) CLC-3 chloride channels moderate long-term potentiation at Schaffer collateral-CA1 synapses. J Physiol 591:1001-15
Sadovsky, Alexander J; MacLean, Jason N (2013) Scaling of topologically similar functional modules defines mouse primary auditory and somatosensory microcircuitry. J Neurosci 33:14048-60, 14060a
Cipolla, Marilyn J; Pusic, Aya D; Grinberg, Yelena Y et al. (2012) Pregnant serum induces neuroinflammation and seizure activity via TNFýý. Exp Neurol 234:398-404

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