This Molecular Biophysics pre-doctoral training program involves 22 mentors from seven degree-granting departments who provide research training linked to studies of the structure and function of proteins, nucleic acids, and viruses. The program emphasizes training in three sub-disciplines of this area, X-ray Crystallography, Electron Microscopy and Imaging, and NMR Spectroscopy. Inasmuch as biophysics and structural biology are not traditional undergraduate disciplines, the curriculum includes courses that offer entry points for students from diverse backgrounds with differing knowledge of biology, chemistry, physics, and mathematics as well as advanced courses that add deeper theoretical and practical understanding. The Program also delivers significant extracurricular experiences that insure breadth of knowledge and prepare the trainees for careers as scientists. Among these are an annual student-organized and student-presented Biophysics Symposium, and a series of mentor-organized Biophysical Discussions that focus on the scientific and technical context of key seminars. The faculty have a long and successful history in collaborative research and training that enriches the program and benefits the trainees. Similarly, superb major research facilities for crystallography, NMR, and electron microscopy have been established and maintained as shared facilities available to all trainees. ? ?
| Giger, Katie; Habib, Ibrahim; Ritchie, Ken et al. (2016) Diffusion of glycophorin A in human erythrocytes. Biochim Biophys Acta 1858:2839-2845 |
| Clifton, Matthew C; Simon, Michael J; Erramilli, Satchal K et al. (2015) In vitro reassembly of the ribose ATP-binding cassette transporter reveals a distinct set of transport complexes. J Biol Chem 290:5555-65 |
| Dolan, Patrick T; Roth, Andrew P; Xue, Bin et al. (2015) Intrinsic disorder mediates hepatitis C virus core-host cell protein interactions. Protein Sci 24:221-35 |
| Oliver, Justin C; Gudihal, Ravidra; Burgner, John W et al. (2014) Conformational changes involving ammonia tunnel formation and allosteric control in GMP synthetase. Arch Biochem Biophys 545:22-32 |
| Roy, Amitava; Hua, Duy P; Ward, Joshua M et al. (2014) Relative Binding Enthalpies from Molecular Dynamics Simulations Using a Direct Method. J Chem Theory Comput 10:2759-2768 |
| Snyder, Jonathan E; Kulcsar, Kirsten A; Schultz, Kimberly L W et al. (2013) Functional characterization of the alphavirus TF protein. J Virol 87:8511-23 |
| Dolan, Patrick T; Zhang, Chaoying; Khadka, Sudip et al. (2013) Identification and comparative analysis of hepatitis C virus-host cell protein interactions. Mol Biosyst 9:3199-209 |
| Steussy, C Nicklaus; Critchelow, Chandra J; Schmidt, Tim et al. (2013) A novel role for coenzyme A during hydride transfer in 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Biochemistry 52:5195-205 |
| Costakes, Gregory T; Sen, Arpita; Aguilar, R Claudio et al. (2013) Crystallographic analysis of the ENTH domain from yeast epsin Ent2 that induces a cell division phenotype. Protein Sci 22:755-61 |
| St John, Sarah E; Jensen, Katherine C; Kang, Soosung et al. (2013) Design, synthesis, biological and structural evaluation of functionalized resveratrol analogues as inhibitors of quinone reductase 2. Bioorg Med Chem 21:6022-37 |
Showing the most recent 10 out of 47 publications
