This proposal requests renewal funding for the Predoctoral Biotechnology Training Program at Northwestern University. This interdisciplinary and interdepartmental Program offers biotechnology training opportunities for a select group of PhD students from five participating units: the Departments of Biological &Chemical Engineering (ChBE), Biomedical Engineering (BME), Material Sciences &Engineering (MSE), Chemistry (Chem), and the Interdepartmental Biological Sciences (IBiS) graduate program. Research opportunities, chosen from among a selection of laboratories in the life sciences, are complemented by a core interdisciplinary curriculum. Three- to 6-month industrial internships expose trainees to the industrial environment of modern biotechnology. All trainees and many preceptors participate in the IBiS, 2-day, off-campus annual retreat, which allows extensive interactions among students and faculty from many disciplines and increases the cohesiveness of the trainee group. The Biotechnology Research in Progress Meetings occur monthly and is the forum where trainees and faculty present and discuss their research results and interact with other trainees. Trainees organize and host a Biotechnology Seminar Series that bring industrial and academic scientists to campus for discussions with trainees. Students also take advantage of several other life sciences-related seminar programs on campus, notably the annual Kellogg Biotechnology Conference and seminars for the Master's in Biotechnology Program. Instruction in the responsible conduct of research is carried out primarily through the course, "Ethics in Biological Research." Trainees are recruited by the Program and the participating units using brochures, www pages, and conference presentations. Intensive efforts are made to recruit student from underrepresented groups, and have been quite successful with 30% of trainees from the past 4 years from underrepresented groups. Trainees have been selected from Chemistry, BME, ChBE, and IBiS, and we propose to add MSE for the renewal due to their efforts in biotechnology research and strength of the faculty and the graduate student pool. The number of preceptors participating in the Program will increase from 31 to 42. An increase from 6 to 8 funded positions is requested to support this expanded preceptor base and available student pool.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008449-20
Application #
8496798
Study Section
Special Emphasis Panel (ZGM1-BRT-2 (MB))
Program Officer
Gerratana, Barbara
Project Start
1993-09-01
Project End
2014-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
20
Fiscal Year
2013
Total Cost
$165,499
Indirect Cost
$12,735
Name
Northwestern University at Chicago
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
160079455
City
Evanston
State
IL
Country
United States
Zip Code
60201
Duncan, Mark T; DeLuca, Teresa A; Kuo, Hsin-Yu et al. (2016) SIRT1 is a critical regulator of K562 cell growth, survival, and differentiation. Exp Cell Res 344:40-52
Allen, Sean; Liu, Yu-Gang; Scott, Evan (2016) Engineering nanomaterials to address cell-mediated inflammation in atherosclerosis. Regen Eng Transl Med 2:37-50
Schwarz, Kelly A; Leonard, Joshua N (2016) Engineering cell-based therapies to interface robustly with host physiology. Adv Drug Deliv Rev 105:55-65
Younger, Andrew K D; Dalvie, Neil C; Rottinghaus, Austin G et al. (2016) Engineering Modular Biosensors to Confer Metabolite-Responsive Regulation of Transcription. ACS Synth Biol :
Peñalver Bernabé, Beatriz; Shin, Seungjin; Rios, Peter D et al. (2016) Dynamic transcription factor activity networks in response to independently altered mechanical and adhesive microenvironmental cues. Integr Biol (Camb) 8:844-60
Large, Edward E; Xu, Wen; Zhao, Yuehui et al. (2016) Selection on a Subunit of the NURF Chromatin Remodeler Modifies Life History Traits in a Domesticated Strain of Caenorhabditis elegans. PLoS Genet 12:e1006219
Alhasan, Ali H; Scott, Alexander W; Wu, Jia J et al. (2016) Circulating microRNA signature for the diagnosis of very high-risk prostate cancer. Proc Natl Acad Sci U S A 113:10655-60
Liu, Jeffrey M H; Zhang, Jesse; Zhang, Xiaomin et al. (2016) Transforming growth factor-beta 1 delivery from microporous scaffolds decreases inflammation post-implant and enhances function of transplanted islets. Biomaterials 80:11-9
Daringer, Nichole M; Schwarz, Kelly A; Leonard, Joshua N (2015) Contributions of unique intracellular domains to switchlike biosensing by Toll-like receptor 4. J Biol Chem 290:8764-77
Hung, Michelle E; Leonard, Joshua N (2015) Stabilization of exosome-targeting peptides via engineered glycosylation. J Biol Chem 290:8166-72

Showing the most recent 10 out of 76 publications