The Chemistry Biology Interface Training Program (CBIT) provides graduate students at the University of Wisconsin-Madison with a training experience designed to allow them to apply interdisciplinary approaches and ideas to make major breakthroughs. This project has two inter-related objectives. The first is to train graduate students to address synthetic and mechanistic problems that transcend the traditional boundaries of chemistry and biology. In this way, trainees will be prepared for careers in which they illuminate key issues in human health through innovative approaches. The second is to provide career advice and assistance so that trainees can use their training and skills to maximize their impact. These objectives are achieved through the unique training plan offered graduate student trainees. This renewal requests support for twelve predoctoral trainees per year; each trainee will be appointed to the program for up to three years. CBIT trainees enroll in three courses including a didactic course in the field of chemical biology that introduces graduate students to research and concepts at the intersection of chemistry and biology, an advanced literature seminar course in chemical biology where students present and discuss recent key publications in the field, and a research seminar in which trainees present their personal research results. Through this program, CBIT trainees receive experience in analysis of the literature, grant writing, and peer review. They also develop their oral communication skills through giving different types of presentations and receiving extensive feedback on how to enhance the effectiveness of their presentations. Another key element of the CBIT is career advising and development for all trainees, which occurs through the creation of individual development plans and participation in a newly implemented Midwest Chemistry Biology Interface Career Development Conference. Finally, CBIT trainees benefit from the opportunity to participate in a 10-12-week internship. The goal of this feature is to immerse them in an environment that provides direct experience in a relevant setting distinct from a research university.

Public Health Relevance

The Chemistry Biology Interface Training Program (CBIT) provides graduate students at the University of Wisconsin-Madison with a training experience designed to allow them to use interdisciplinary ideas and approaches to make major biomedical breakthroughs. The program trains graduate students to address problems that transcend the traditional boundaries of chemistry and biology and also provides trainees with career plan development assistance. Training at the chemistry---biology interface is ideal preparation for designing, discovering, and developing the next generation of therapeutic agents, which will directly impact human health.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Training and Workforce Development Subcommittee - D (TWD)
Program Officer
Fabian, Miles
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Wisconsin Madison
Earth Sciences/Resources
United States
Zip Code
Chevrette, Marc G; Aicheler, Fabian; Kohlbacher, Oliver et al. (2017) SANDPUMA: ensemble predictions of nonribosomal peptide chemistry reveal biosynthetic diversity across Actinobacteria. Bioinformatics 33:3202-3210
Pallares, Ivan G; Moore, Theodore C; Escalante-Semerena, Jorge C et al. (2017) Spectroscopic Studies of the EutT Adenosyltransferase from Salmonella enterica: Evidence of a Tetrahedrally Coordinated Divalent Transition Metal Cofactor with Cysteine Ligation. Biochemistry 56:364-375
Ni, Dalong; Bu, Wenbo; Ehlerding, Emily B et al. (2017) Engineering of inorganic nanoparticles as magnetic resonance imaging contrast agents. Chem Soc Rev 46:7438-7468
Shi, Sixiang; Xu, Cheng; Yang, Kai et al. (2017) Chelator-Free Radiolabeling of Nanographene: Breaking the Stereotype of Chelation. Angew Chem Int Ed Engl 56:2889-2892
Ehlerding, Emily B; England, Christopher G; Jiang, Dawei et al. (2017) CD38 as a PET Imaging Target in Lung Cancer. Mol Pharm 14:2400-2406
Zayas-Gonzalez, Yashira M; Ortiz, Benjamín J; Lynn, David M (2017) Layer-by-Layer Assembly of Amine-Reactive Multilayers Using an Azlactone-Functionalized Polymer and Small-Molecule Diamine Linkers. Biomacromolecules 18:1499-1508
Zhan, Yonghua; Shi, Sixiang; Ehlerding, Emily B et al. (2017) Radiolabeled, Antibody-Conjugated Manganese Oxide Nanoparticles for Tumor Vasculature Targeted Positron Emission Tomography and Magnetic Resonance Imaging. ACS Appl Mater Interfaces 9:38304-38312
Veling, Mike T; Reidenbach, Andrew G; Freiberger, Elyse C et al. (2017) Multi-omic Mitoprotease Profiling Defines a Role for Oct1p in Coenzyme Q Production. Mol Cell 68:970-977.e11
Blin, Kai; Wolf, Thomas; Chevrette, Marc G et al. (2017) antiSMASH 4.0-improvements in chemistry prediction and gene cluster boundary identification. Nucleic Acids Res :
Bhute, Vijesh J; Bao, Xiaoping; Dunn, Kaitlin K et al. (2017) Metabolomics Identifies Metabolic Markers of Maturation in Human Pluripotent Stem Cell-Derived Cardiomyocytes. Theranostics 7:2078-2091

Showing the most recent 10 out of 230 publications