This T32 Trauma Training Program is designed to train surgical residents in the fundamentals of basic research. This is accomplished using a training committee comprised of a principal trainer and a team of associate trainers in a closely supervised training program. The training scheme is based on weekly interactions between the training committee and the trainee in the form of twice weekly training research sessions. The trauma research program is integrated into a department-wide (Surgery) surgeon-scientist training program where all residents in the General Surgery Training Program participate in a two or three year curriculum designed to provide research training. A tract to obtain a Ph.D. through the Department of Pharmacology is available for trainees who commit to three years of training. Funding for five positions is sought to support trainees who enter the program after two or three years of surgical residency. A few Ph.D. post-docs will be accepted as well. The research areas are all based on trauma and its consequences. Much of the research is supported by a P50 Trauma Center Grant entitled "The Molecular Biology of Hemorrhagic Shock". Understanding the regulation and consequences of trauma-induced inflammation is at the core of much of the research training. The program introduces systems biology concepts in the training as well as opportunities in regenerative medicine relevant to trauma research.

Public Health Relevance

Trauma is the most common cause of death and morbidity for people under the age of 50 years. Progress in reducing the death rate and serious complications that occur after injury requires individuals trained not only in the clinical care of surgical patients, but also the fundamentals of basic research. This training program is designed to prepare surgeons to identify the appropriate research questions and equip these clinician- investinatnrs with the skills nfiRdfici tn nrnvidfi the answers fnr the benefit nf trauma patients.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008516-20
Application #
8500324
Study Section
Special Emphasis Panel (ZGM1-BRT-5 (PD))
Program Officer
Somers, Scott D
Project Start
1994-07-01
Project End
2014-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
20
Fiscal Year
2013
Total Cost
$174,461
Indirect Cost
$22,495
Name
University of Pittsburgh
Department
Surgery
Type
Schools of Medicine
DUNS #
004514360
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
Brown, Joshua B; Cohen, Mitchell J; Minei, Joseph P et al. (2015) Pretrauma center red blood cell transfusion is associated with reduced mortality and coagulopathy in severely injured patients with blunt trauma. Ann Surg 261:997-1005
Brown, Joshua B; Forsythe, Raquel M; Stassen, Nicole A et al. (2014) Evidence-based improvement of the National Trauma Triage Protocol: The Glasgow Coma Scale versus Glasgow Coma Scale motor subscale. J Trauma Acute Care Surg 77:95-102; discussion 101-2
Howell, Gina M; Gomez, Hernando; Collage, Richard D et al. (2013) Augmenting autophagy to treat acute kidney injury during endotoxemia in mice. PLoS One 8:e69520
Li, Hui; Rodriguez, Janel; Yoo, Youngdong et al. (2011) Cooperative and antagonistic contributions of two heterochromatin proteins to transcriptional regulation of the Drosophila sex determination decision. PLoS Genet 7:e1002122
McCloskey, Carol A; Kameneva, Marina V; Uryash, Arkady et al. (2004) Tissue hypoxia activates JNK in the liver during hemorrhagic shock. Shock 22:380-6
McCloskey, Carol A; Zuckerbraun, Brian S; Gallo, David J et al. (2003) A role for angiotensin II in the activation of extracellular signal-regulated kinases in the liver during hemorrhagic shock. Shock 20:316-9
Chen, L C; Kepka-Lenhart, D; Wright, T M et al. (1999) Salicylate-enhanced activation of transcription factors induced by interferon-gamma. Biochem J 342 Pt 3:503-7
Morris Jr, S M; Kepka-Lenhart, D; Chen, L C (1998) Differential regulation of arginases and inducible nitric oxide synthase in murine macrophage cells. Am J Physiol 275:E740-7