The University of North Carolina Molecular and Cellular Biophysics Training Program (PMCB) is an interdisciplinary graduate training program with three essential aims: 1. to attract talented post-graduate students to apply the methods and concepts of the quantitative and mathematical sciences to problems in biology. 2. to provide a flexible vehicle for training this diverse group of graduate students who share with our biophysics faculty a commitment to developing molecular level descriptions of complex biological systems and processes. 3. to foster interactions and enhance the training and research environment within this diverse group of faculty and students. The PMCB continues to excel in meeting all three Aims, and most recently has expanded its focus to establish with the Biophysical Society a Summer Course in Biophysics designed to attract talented minority undergraduate students to the field as well. Significant changes in the organization of science graduate programs at UNC have necessitated changes in our Program as well and have led to plans for a PhD degree program in biophysics at UNC. This application is for continued funding of our successful training efforts and in support our efforts to move forward in these new areas.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Flicker, Paula F
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of North Carolina Chapel Hill
Schools of Medicine
Chapel Hill
United States
Zip Code
Pellock, Samuel J; Redinbo, Matthew R (2017) Glucuronides in the gut: Sugar-driven symbioses between microbe and host. J Biol Chem 292:8569-8576
Byrnes, Amy E; Slep, Kevin C (2017) TOG-tubulin binding specificity promotes microtubule dynamics and mitotic spindle formation. J Cell Biol 216:1641-1657
Smola, Matthew J; Christy, Thomas W; Inoue, Kaoru et al. (2016) SHAPE reveals transcript-wide interactions, complex structural domains, and protein interactions across the Xist lncRNA in living cells. Proc Natl Acad Sci U S A 113:10322-7
Page, Stephani C; Immormino, Robert M; Miller, Thane H et al. (2016) Experimental Analysis of Functional Variation within Protein Families: Receiver Domain Autodephosphorylation Kinetics. J Bacteriol 198:2483-93
Jacobs, T M; Williams, B; Williams, T et al. (2016) Design of structurally distinct proteins using strategies inspired by evolution. Science 352:687-90
Huynh, Minh V; Campbell, Sharon L (2016) Getting a Handle on RAS-targeted Therapies: Cysteine Directed Inhibitors. Mini Rev Med Chem 16:383-90
Hallett, Ryan A; Zimmerman, Seth P; Yumerefendi, Hayretin et al. (2016) Correlating in Vitro and in Vivo Activities of Light-Inducible Dimers: A Cellular Optogenetics Guide. ACS Synth Biol 5:53-64
Kang, SunAh; Rogers, Jennifer L; Monteith, Andrew J et al. (2016) Apoptotic Debris Accumulates on Hematopoietic Cells and Promotes Disease in Murine and Human Systemic Lupus Erythematosus. J Immunol 196:4030-9
Harrison, Joseph S; Jacobs, Tim M; Houlihan, Kevin et al. (2016) UbSRD: The Ubiquitin Structural Relational Database. J Mol Biol 428:679-687
Cribb, Jeremy A; Osborne, Lukas D; Beicker, Kellie et al. (2016) An Automated High-throughput Array Microscope for Cancer Cell Mechanics. Sci Rep 6:27371

Showing the most recent 10 out of 61 publications