The UCSC graduate training program in Molecular, Cellular, and Developmental Biology provides intensive training in the skills necessary for outstanding research in modern biology. First year trainees undertake coursework emphasizing critical evaluation of scientific models and experimental results, and they also participate in three ten-week laboratory rotations. Second-year students take an oral qualifying exam, and advanced students participate in a variety of seminars, advanced special topics courses, and research group meetings designed to provide continuing learning opportunities. The goal of the training program is to produce graduates who have a strong foundation in the specific area of their thesis research, as well as broad training and knowledge in molecular, cellular, and developmental biology. The program is administered by Advising and Admissions Committees according to policy guidelines stated in our Graduate Handbook and Faculty Guidelines. The training program is composed of 19 members of the Department of IVICD Biology, and 9 affiliated faculty from the Departments of Biomolecular Engineering, Chemistry and Biochemistry, and Microbiology and Environmental Toxicology. The majority of the faculty members are housed in the Sinsheimer Laboratories, with other faculty located in the Physical Sciences Building, which is adjacent to Sinsheimer Labs. The MCD training program provides an interactive and collaborative research environment for graduate training. Research in the training program utilizes a wide variety of approaches and model organisms, and is organized as interdisciplinary clusters of faculty with shared interests, thereby creating critical masses of researchers that foster mutual support and scientific interaction. During the first 10 years of NIH training support we have recruited and trained outstanding students who would be amongst the best students in any training program. We are requesting a total of 8 predoctoral trainee positions in this renewal, which will continue to be awarded to our best students. Relevance: Students in the MCD Biology training program have extensive opportunities to study topics related to human health. Many training faculty work on systems that are directly relevant to human health, including stem cell biology, malaria, cholera, cancer biology, host-pathogen interactions, neurodegenerative diseases, and the responses of neurons to stroke and other damage. Other faculty carry out basic research that provides the foundation for understanding topics relevant to human health, including research focused on cell division, signaling, meiosis, chromatin remodeling, cell differentiation, and neurobiology.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
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National Institute of General Medical Sciences Initial Review Group (BRT)
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Gindhart, Joseph G
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University of California Santa Cruz
Schools of Arts and Sciences
Santa Cruz
United States
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Peterson, Misty R; Hamdani, Omar; Kamakaka, Rohinton T (2017) Methods to Study the Atypical Roles of DNA Repair and SMC Proteins in Gene Silencing. Methods Mol Biol 1515:151-176
Kessenbrock, Kai; Smith, Prestina; Steenbeek, Sander Christiaan et al. (2017) Diverse regulation of mammary epithelial growth and branching morphogenesis through noncanonical Wnt signaling. Proc Natl Acad Sci U S A 114:3121-3126
Bogdanoff, Walter A; Campos, Jocelyn; Perez, Edmundo I et al. (2017) Structure of a Human Astrovirus Capsid-Antibody Complex and Mechanistic Insights into Virus Neutralization. J Virol 91:
Cuoco, Joshua A; Esposito, Anthony W; Moriarty, Shannon et al. (2017) Malformation of the Posterior Cerebellar Vermis Is a Common Neuroanatomical Phenotype of Genetically Engineered Mice on the C57BL/6 Background. Cerebellum :
Neeb, Zachary T; Hogan, Daniel J; Katzman, Sol et al. (2017) Preferential expression of scores of functionally and evolutionarily diverse DNA and RNA-binding proteins during Oxytricha trifallax macronuclear development. PLoS One 12:e0170870
Fagg, W Samuel; Liu, Naiyou; Fair, Jeffrey Haskell et al. (2017) Autogenous cross-regulation of Quaking mRNA processing and translation balances Quaking functions in splicing and translation. Genes Dev 31:1894-1909
Brose, Lotti; Crest, Justin; Tao, Li et al. (2017) Polo kinase mediates the phosphorylation and cellular localization of Nuf/FIP3, a Rab11 effector. Mol Biol Cell 28:1435-1443
Carlson, Scott M; Soulette, Cameron M; Yang, Ze et al. (2017) RBM25 is a global splicing factor promoting inclusion of alternatively spliced exons and is itself regulated by lysine mono-methylation. J Biol Chem 292:13381-13390
Covarrubias, Sergio; Robinson, Elektra K; Shapleigh, Barbara et al. (2017) CRISPR/Cas-based screening of long non-coding RNAs (lncRNAs) in macrophages with an NF-?B reporter. J Biol Chem 292:20911-20920
Kaneshiro, Kiyomi R; Strome, Susan (2017) Inheritance of protection from osmotic stress. Nat Cell Biol 19:151-152

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