We are requesting continued funding of the Medical Sciences Training Program (MSTP) at the University of Wisconsin-Madison (UW-Madison). Core philosophies that have shaped the program are (1) the rigor and caliber of both MD and PhD training should be equivalent to those of single degree candidates;(2) students learn from one another;and (3) graduates, albeit to variable degrees, will be engaged in translational research. Three physician-scientists of the School of Medicine and Public Health, each of whom is active in research, graduate training, and clinical activities, direct the MSTP. A student organization works closely with the directors. Directors are advised by the MSTP Steering Committee, which includes faculty from multiple disciplines and ensures that the MSTP exploits the breadth of training opportunities available to students at UW-Madison. The usual student does the preclinical phase of medical training while becoming acquainted with research methodologies in a four-semester seminar/journal club course and participating in research rotations. Research mentors and graduate programs are chosen in the second year. A clinical bridging curriculum facilitates the transitions between medical and graduate studies. All students are introduced to clinical research. Clinical clerkships are done after completion of the Ph.D. thesis. Although the majority of student theses are in the biological and chemical sciences, a significant number of students are doing research in clinical investigation, on population-based problems, or in engineering. Students produce substantial dissertations that result in important publications. Activities that foster program cohesiveness include the strong student organization, a weekly seminar, yearly retreat, yearly symposium, and regular social gatherings. To have an interactive and dynamic group of students, we are aiming for a class size of ten students for an overall program size of 80 students. Our long-term goal is to train a diverse group of physician-scientists who will have major impact on biomedical research and the practice of medicine and be future academic and research leaders.

Public Health Relevance

The overall goal of the Medical Scientist (MD/PhD) Training Program (MSTP) at the University of Wisconsin-Madison (UW-Madison) is to train physician-scientists in the broad range of research areas critical to advancing frontiers of medical knowledge and therapeutics. Integrated MD/PhD programs, by immersing trainees in research during what are arguably their most impressionable and creative years, are a key component of our country's portfolio to provide such training and fit perfectly the missions of UW-Madison and its School of Medicine and Public Health (SMPH). UW-Madison consistently ranks as one of the top 20 research universities in the world and is especially well known for graduate education and contributions to society. Research and education related to biomedicine are carried out in a large number of departments, centers, and programs inside and outside of the SMPH that are integrated, collaborative, and span the many disciplines that will improve the health of our nation and world.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008692-15
Application #
8279191
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Preusch, Peter C
Project Start
1998-07-01
Project End
2016-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
15
Fiscal Year
2012
Total Cost
$516,016
Indirect Cost
$23,348
Name
University of Wisconsin Madison
Department
Biochemistry
Type
Schools of Medicine
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Wentland, Andrew L; Wieben, Oliver; Shanmuganayagam, Dhanansayan et al. (2015) Measurements of wall shear stress and aortic pulse wave velocity in swine with familial hypercholesterolemia. J Magn Reson Imaging 41:1475-85
Chiang, Jason; Birla, Sohan; Bedoya, Mariajose et al. (2015) Modeling and validation of microwave ablations with internal vaporization. IEEE Trans Biomed Eng 62:657-63
Jackson, Shawn S; Oberley, Christopher; Hooper, Christopher P et al. (2015) Withaferin A disrupts ubiquitin-based NEMO reorganization induced by canonical NF-?B signaling. Exp Cell Res 331:58-72
Stefely, Jonathan A; Reidenbach, Andrew G; Ulbrich, Arne et al. (2015) Mitochondrial ADCK3 employs an atypical protein kinase-like fold to enable coenzyme Q biosynthesis. Mol Cell 57:83-94
Wentland, Andrew L; McWalter, Emily J; Pal, Saikat et al. (2015) Muscle velocity and inertial force from phase contrast MRI. J Magn Reson Imaging 42:526-32
LaRocque, Joshua J; Eichenbaum, Adam S; Starrett, Michael J et al. (2015) The short- and long-term fates of memory items retained outside the focus of attention. Mem Cognit 43:453-68
Raval, Kunil K; Tao, Ran; White, Brent E et al. (2015) Pompe disease results in a Golgi-based glycosylation deficit in human induced pluripotent stem cell-derived cardiomyocytes. J Biol Chem 290:3121-36
Caì, Yíngyún; Postnikova, Elena N; Bernbaum, John G et al. (2015) Simian hemorrhagic fever virus cell entry is dependent on CD163 and uses a clathrin-mediated endocytosis-like pathway. J Virol 89:844-56
Chang, Timothy S; Gangnon, Ronald E; David Page, C et al. (2015) Sparse modeling of spatial environmental variables associated with asthma. J Biomed Inform 53:320-9
Ma, Shi-Dong; Xu, Xuequn; Plowshay, Julie et al. (2015) LMP1-deficient Epstein-Barr virus mutant requires T cells for lymphomagenesis. J Clin Invest 125:304-15

Showing the most recent 10 out of 100 publications