The overall goal of this existing training program is to provide a focused 2-3 year research experience for up to two clinical residents-in- training (predominantly in surgery) expressing a commitment to a career in trauma, injury, burn or inflammation research. The research program will focus on mastery of molecular biology, functional genomics and gene therapy, as it applies to inflammation research. This program will take advantage of the unique strengths of the College of Medicine in the expanding field of functional genomics, gene therapy and molecular biology, as well as the collaborations between basic scientists and clinicians committed to the training of future clinical academicians. The interface between molecular biology and inflammation research will be targeted to ARDS, sepsis syndromes, ischemia/reperfusion injury, delayed wound healing and the burn wound, The faculty will be drawn from funded basic scientists in the Surgery, Obstetrics/ Gynecology, and Molecular Genetics and Microbiology Departments, who will serve as research mentors to the trainees. Clinical mentors from the Surgery, Anesthesiology , Medicine and Pathology Departments will interact with the trainees and the research faculty to assure that the trainees are being exposed to clinically-important issues in inflammation research. Overall direction of the program will rest with the Principal Investigator and the Executive Committee. Candidates for the fellowship will be recruited nationally and from the University of Florida College of Medicine. Successful applicants with the Executive Committee will identify a research and clinical mentor who will help formulate a formal training program and periodic review of the trainee's progress. The bulk of the training program will be in the laboratory of an experienced research mentor, but trainees will also be required to fulfill basic course work in research ethics and statistical methods, and will be encouraged to obtain supplemental didactic training in molecular biology, taking advantage of Ph.D. programs available to them, if appropriate.. Furthermore, trainees are expected to participate in seminars in the Powell Gene Therapy Center and Genetics Institute, and in their basic science departments, as well as laboratory research meetings. They will also be expected to attend clinical seminars, including Surgery and Critical Care Medicine Grand Rounds. It is anticipated that successful graduates will possess sufficient research skills to compete for transitional funding in inflammation research.

Public Health Relevance

Society recognizes the critical role that clinician-scientists play in translational biology and the application of new technologies to the clinic. We propose that a 2-3 year immersion by a young interested clinician in the laboratory of a successful basic scientist with expertise in molecular biology will provide a sound foundation for a career as a physician/scientist involved in translational research. The successful trainees will have the expertise in functional genomics, gene therapy and molecular biology to help translate the current genetic revolution to trauma practice.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM008721-14
Application #
8284328
Study Section
Special Emphasis Panel (ZGM1-BRT-5 (PD))
Program Officer
Somers, Scott D
Project Start
1999-07-01
Project End
2014-06-30
Budget Start
2012-07-01
Budget End
2013-06-30
Support Year
14
Fiscal Year
2012
Total Cost
$118,321
Indirect Cost
$8,571
Name
University of Florida
Department
Surgery
Type
Schools of Medicine
DUNS #
969663814
City
Gainesville
State
FL
Country
United States
Zip Code
32611
Rosenthal, Martin D; Moore, Frederick A (2016) Persistent Inflammation, Immunosuppression, and Catabolism: Evolution of Multiple Organ Dysfunction. Surg Infect (Larchmt) 17:167-72
Loftus, Tyler J; Efron, Philip A; Moldawer, Lyle L et al. (2016) β-Blockade use for Traumatic Injuries and Immunomodulation: A Review of Proposed Mechanisms and Clinical Evidence. Shock 46:341-51
Mathias, Brittany; Delmas, Amber L; Ozrazgat-Baslanti, Tezcan et al. (2016) Human Myeloid-derived Suppressor Cells are Associated With Chronic Immune Suppression After Severe Sepsis/Septic Shock. Ann Surg :
Loftus, Tyler J; Brakenridge, Scott C; Moore, Frederick A et al. (2016) Routine surveillance cholangiography following percutaneous cholecystostomy delays drain removal and cholecystectomy. J Trauma Acute Care Surg :
Loftus, Tyler J; Jordan, Janeen R; Croft, Chasen A et al. (2016) Temporary abdominal closure for trauma and intra-abdominal sepsis: different patients, different outcomes. J Trauma Acute Care Surg :
DeSart, Kenneth; O'Malley, Kerri; Schmit, Bradley et al. (2016) Systemic inflammation as a predictor of clinical outcomes after lower extremity angioplasty/stenting. J Vasc Surg 64:766-778.e5
Lopez, Maria-Cecilia; Efron, Philip A; Ozrazgat-Baslanti, Tezcan et al. (2016) Sex-based differences in the genomic response, innate immunity, organ dysfunction, and clinical outcomes after severe blunt traumatic injury and hemorrhagic shock. J Trauma Acute Care Surg 81:478-85
Loftus, Tyler J; Go, Kristina L; Hughes, Steven J et al. (2016) Improved outcomes following implementation of an acute gastrointestinal bleeding multidisciplinary protocol. J Trauma Acute Care Surg :
Mira, Juan C; Szpila, Benjamin E; Nacionales, Dina C et al. (2016) Patterns of gene expression among murine models of hemorrhagic shock/trauma and sepsis. Physiol Genomics 48:135-44
Alamo, Ines G; Kannan, Kolenkode B; Ramos, Harry et al. (2016) Clonidine reduces norepinephrine and improves bone marrow function in a rodent model of lung contusion, hemorrhagic shock, and chronic stress. Surgery :

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