This proposal requests support for the MSTP at the University of Cincinnati College of Medicine (UCCOM). Our dual-degree program was established in 1985 and has been continuously NIH-funded for over 10 years. It enrolls 7 new students each year and currently includes 43 students. The central goal of the UCCOM MSTP is to train physician scientists who will be the leaders in their respective fields in academic medicine. Our Program is supported by a solid infrastructure in clinical and research training. Our students can choose from 10 diverse graduate programs. The success of our Program is best illustrated by the success of our graduates - 77% of our graduates have established careers in academic medicine and are actively engaged in research. Our students come from a diverse applicant pool drawn from across the nation. In 2012 (for class matriculating in 2012), we had 157 applicants from 35 states, and our current MSTP students include 12% URM and 11.6% disadvantaged/disabled students. The average time to complete our MSTP for the last 10 years is 7.8 years and our students have matched at the most competitive residency programs. Since the last funding period, several important and exciting developments have taken place including the appointment of a new director and associate directors, a newly designed and recently implemented integrated medical school curriculum, which provides early clinical training (starting in first semester) and re-engagement with basic science in the last clinical years, expansion of both UCCOM and Cincinnati Children's Hospital Medical Center (CCHMC) facilities, increased number and breadth of training opportunities for MD/PhD candidates, increased extramural research support, and an increase in the size of the graduate programs. We are confident that we can continue to achieve our aims and meet the central goal of our program. Towards this goal, we are requesting continued support for 8 positions.

Public Health Relevance

The need for investigators who are well trained in both basic science and clinical research has been and continues to be an unmet need. NIGMS Medical Scientist Training Programs (MSTP) was developed to meet the need for more physician scientists and offer unique training opportunities. The UCCOM MSTP has been successful with 77% of its MSTP graduates in academic careers consistent with their training as physician scientists

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
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Study Section
Special Emphasis Panel (TWD)
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Preusch, Peter C
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University of Cincinnati
Schools of Medicine
United States
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Harley, Isaac T W; Stankiewicz, Traci E; Giles, Daniel A et al. (2014) IL-17 signaling accelerates the progression of nonalcoholic fatty liver disease in mice. Hepatology 59:1830-9
Boespflug, Nicholas D; Kumar, Sachin; McAlees, Jaclyn W et al. (2014) ATF3 is a novel regulator of mouse neutrophil migration. Blood 123:2084-93
Kuethe, Joshua W; Mintz-Cole, Rachael; Johnson 3rd, Bobby L et al. (2014) Assessing the immune status of critically ill trauma patients by flow cytometry. Nurs Res 63:426-34
Breidenbach, Andrew P; Gilday, Steven D; Lalley, Andrea L et al. (2014) Functional tissue engineering of tendon: Establishing biological success criteria for improving tendon repair. J Biomech 47:1941-8
Hollie, Norris I; Konaniah, Eddy S; Goodin, Colleen et al. (2014) Group 1B phospholipase A? inactivation suppresses atherosclerosis and metabolic diseases in LDL receptor-deficient mice. Atherosclerosis 234:377-80
McCracken, Kyle W; Catá, Emily M; Crawford, Calyn M et al. (2014) Modelling human development and disease in pluripotent stem-cell-derived gastric organoids. Nature 516:400-4
Jiang, Tony T; Chaturvedi, Vandana; Ertelt, James M et al. (2014) Regulatory T cells: new keys for further unlocking the enigma of fetal tolerance and pregnancy complications. J Immunol 192:4949-56
Hollie, Norris I; Cash, James G; Matlib, M Abdul et al. (2014) Micromolar changes in lysophosphatidylcholine concentration cause minor effects on mitochondrial permeability but major alterations in function. Biochim Biophys Acta 1841:888-95
Kay, Benjamin; Szaflarski, Jerzy P (2014) EEG/fMRI contributions to our understanding of genetic generalized epilepsies. Epilepsy Behav 34:129-35
Gilday, Steven D; Casstevens, E Chris; Kenter, Keith et al. (2014) Murine patellar tendon biomechanical properties and regional strain patterns during natural tendon-to-bone healing after acute injury. J Biomech 47:2035-42

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