This proposal requests continuing support for a Chemistry-Biology Interface (CBI) Training Program at Vanderbilt University. Twenty eight faculty preceptors from five departments in the College of Arts and Sciences and in the School of Medicine will serve as mentors for the Program. Significant biological training will be provided to students receiving in-depth training in synthetic/mechanistic chemistry and significant training in synthetic/mechanistic chemistry will be provided to students receiving in-depth training in the biological sciences. Highlights of the training program include a chemical biology curriculum, elective courses for specialized training, and an interactive seminar series in chemical biology, an annual research retreat and an in-depth laboratory research experience. Students will be well-grounded in a core discipline and sufficiently well-trained in complementary fields to allow them to work effectively in a multi-disciplinary environment. Support for eight trainees is requested. Trainees will obtain Ph.D. degrees working with preceptors in the Departments of Biochemistry (6 preceptors), Chemistry (13 preceptors), Microbiology and Immunology (1 preceptor), Molecular Physiology and Biophysics (1 preceptor) and Pharmacology (7 preceptors). Lay language description: Advances in biotechnology, drug discovery and related life science fields require the exchange of ideas and knowledge between the fields of chemistry and biology. One objective of this training program is to develop a future generation of scientists who apply an understanding of chemistry and biology to biomedical related problems.

National Institute of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Institutional National Research Service Award (T32)
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Special Emphasis Panel (ZGM1-BRT-5 (TG))
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Fabian, Miles
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Vanderbilt University Medical Center
Schools of Medicine
United States
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Vincent, Jessica; Adura, Carolina; Gao, Pu et al. (2017) Small molecule inhibition of cGAS reduces interferon expression in primary macrophages from autoimmune mice. Nat Commun 8:750
Covington, Brett C; McLean, John A; Bachmann, Brian O (2017) Comparative mass spectrometry-based metabolomics strategies for the investigation of microbial secondary metabolites. Nat Prod Rep 34:6-24
Surdel, Matthew C; Horvath Jr, Dennis J; Lojek, Lisa J et al. (2017) Antibacterial photosensitization through activation of coproporphyrinogen oxidase. Proc Natl Acad Sci U S A 114:E6652-E6659
Sedgeman, Carl A; Su, Yan; Guengerich, F Peter (2017) Formation of S-[2-(N6-Deoxyadenosinyl)ethyl]glutathione in DNA and Replication Past the Adduct by Translesion DNA Polymerases. Chem Res Toxicol 30:1188-1196
Quesada-Gómez, Carlos; López-Ureña, Diana; Chumbler, Nicole et al. (2016) Analysis of TcdB Proteins within the Hypervirulent Clade 2 Reveals an Impact of RhoA Glucosylation on Clostridium difficile Proinflammatory Activities. Infect Immun 84:856-65
Geanes, Alexander R; Cho, Hykeyung P; Nance, Kellie D et al. (2016) Ligand-based virtual screen for the discovery of novel M5 inhibitor chemotypes. Bioorg Med Chem Lett 26:4487-4491
Wakeman, Catherine A; Moore, Jessica L; Noto, Michael J et al. (2016) The innate immune protein calprotectin promotes Pseudomonas aeruginosa and Staphylococcus aureus interaction. Nat Commun 7:11951
Tianero, Ma Diarey; Pierce, Elizabeth; Raghuraman, Shrinivasan et al. (2016) Metabolic model for diversity-generating biosynthesis. Proc Natl Acad Sci U S A 113:1772-7
Chong, Katherine M; Leelatian, Nalin; Deguire, Sean M et al. (2016) The use of fluorescently-tagged apoptolidins in cellular uptake and response studies. J Antibiot (Tokyo) 69:327-30
Chumbler, Nicole M; Rutherford, Stacey A; Zhang, Zhifen et al. (2016) Crystal structure of Clostridium difficile toxin A. Nat Microbiol 1:

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