This proposal requests continuing support for a Chemistry-Biology Interface (CBI) Training Program at Vanderbilt University. Thirty four faculty preceptors from five departments in the College of Arts and Sciences and in the School of Medicine will serve as mentors for the Program. Significant biological training will be provided to students receiving in-depth training in synthetic/mechanistic chemistry and significant training in synthetic/mechanistic chemistry will be provided to students receiving in-depth training in the biological sciences. Highlights of the training program include a chemical biology curriculum, elective courses for specialized training, research and professional development workshops, an interactive seminar series in chemical biology, an annual research symposium, peer teaching and an in-depth laboratory research experience. Students will be well-grounded in a core discipline and sufficiently well-trained in complementary fields to allow them to work effectively in an interdisciplinary environment. Support for ten trainees is requested. Trainees will obtain Ph.D. degrees working with preceptors in the Departments of Biochemistry (9 preceptors), Chemistry (11 preceptors), Microbiology and Immunology (2 preceptor), Molecular Physiology and Biophysics (3 preceptor) and Pharmacology (9 preceptors).
The trainees participating in the CBI training program are engaged in a number of NIH-supported projects that employ techniques, understanding and tools of chemistry to study a variety of biomedical problems with relevance to the study of disease mechanism and therapeutic agent development.
|Choby, Jacob E; Skaar, Eric P (2016) Heme Synthesis and Acquisition in Bacterial Pathogens. J Mol Biol 428:3408-28|
|Geanes, Alexander R; Cho, Hykeyung P; Nance, Kellie D et al. (2016) Ligand-based virtual screen for the discovery of novel M5 inhibitor chemotypes. Bioorg Med Chem Lett 26:4487-91|
|Choby, Jacob E; Mike, Laura A; Mashruwala, Ameya A et al. (2016) A Small-Molecule Inhibitor of Iron-Sulfur Cluster Assembly Uncovers a Link between Virulence Regulation and Metabolism in Staphylococcus aureus. Cell Chem Biol 23:1351-1361|
|Wakeman, Catherine A; Moore, Jessica L; Noto, Michael J et al. (2016) The innate immune protein calprotectin promotes Pseudomonas aeruginosa and Staphylococcus aureus interaction. Nat Commun 7:11951|
|Konkle, Mary E; Blobaum, Anna L; Moth, Christopher W et al. (2016) Conservative Secondary Shell Substitution In Cyclooxygenase-2 Reduces Inhibition by Indomethacin Amides and Esters via Altered Enzyme Dynamics. Biochemistry 55:348-59|
|Tianero, Ma Diarey; Pierce, Elizabeth; Raghuraman, Shrinivasan et al. (2016) Metabolic model for diversity-generating biosynthesis. Proc Natl Acad Sci U S A 113:1772-7|
|Quesada-GÃ³mez, Carlos; LÃ³pez-UreÃ±a, Diana; Chumbler, Nicole et al. (2016) Analysis of TcdB Proteins within the Hypervirulent Clade 2 Reveals an Impact of RhoA Glucosylation on Clostridium difficile Proinflammatory Activities. Infect Immun 84:856-65|
|Zackular, Joseph P; Moore, Jessica L; Jordan, Ashley T et al. (2016) Dietary zinc alters the microbiota and decreases resistance to Clostridium difficile infection. Nat Med 22:1330-1334|
|Covington, Brett C; McLean, John A; Bachmann, Brian O (2016) Comparative mass spectrometry-based metabolomics strategies for the investigation of microbial secondary metabolites. Nat Prod Rep :|
|Chumbler, Nicole M; Rutherford, Stacey A; Zhang, Zhifen et al. (2016) Crystal structure of Clostridium difficile toxin A. Nat Microbiol 1:15002|
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