This is the first renewal application for the Chemistry-Biology Interface predoctoral training grant at UCBerkeley. The program provides graduate PhD students with a unique depth of training in the application of chemical principles and techniques to the investigation and modulation of biological systems. The program's goal is to encourage further integration of the fields of chemistry and biology and prepare students for a future of research at this interface. The graduate program provides: 1.) three 10-week rotations for first year students 2.) A core of didactic courses with additional courses selected based on individual student interest, 3.) Seminars, 4.) Annual retreat, 5.) Poster sessions at the end of each rotation period, 6.) Career day, 7.) Super group meetings, 8.) Aphid dissertation at the chemical biology interface, and 9.) aggressive diversity recruitment efforts. The program selects students from the matriculating pools of first year students in the 4 departments of Chemistry, Molecular and Cell Biology, Chemical engineering, and Bioengineering. Students are selected on the basis of their stated interest in chemical biology research, undergraduate scholastic performance, scores on GRE tests, recommendations from faculty at their undergraduate institutions, and previous research experience. The program has thrived during the first five years with 53 current students, 36 participating faculty, and 12 PhD alumni. Each year the pool of qualified applicants grows larger. The program is positioned to expand to keep up with demand. Annual support for 12 first-year students during their rotation period is requested. This proposal trains students to develop competence in the fields of chemistry and biology. Students learn the language and techniques to manipulate biological systems at the molecular level, which is the key for the design of rational means of diagnosis and treatment of pathological processes. Reciprocally, study of biological problems leads to the development of new synthetic and mechanistic tools in the chemical sciences.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM066698-10
Application #
8500339
Study Section
Special Emphasis Panel (ZGM1-BRT-X (TG))
Program Officer
Fabian, Miles
Project Start
2004-07-01
Project End
2014-06-30
Budget Start
2013-07-01
Budget End
2014-06-30
Support Year
10
Fiscal Year
2013
Total Cost
$336,342
Indirect Cost
$16,980
Name
University of California Berkeley
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
124726725
City
Berkeley
State
CA
Country
United States
Zip Code
94704
Bruemmer, Kevin J; Walvoord, Ryan R; Brewer, Thomas F et al. (2017) Development of a General Aza-Cope Reaction Trigger Applied to Fluorescence Imaging of Formaldehyde in Living Cells. J Am Chem Soc 139:5338-5350
McMurry, Jonathan L; Chang, Michelle C Y (2017) Fluorothreonyl-tRNA deacylase prevents mistranslation in the organofluorine producer Streptomyces cattleya. Proc Natl Acad Sci U S A 114:11920-11925
Jolly, Amber L; Agarwal, Paresh; Metruccio, Matteo M E et al. (2017) Corneal surface glycosylation is modulated by IL-1R and Pseudomonas aeruginosa challenge but is insufficient for inhibiting bacterial binding. FASEB J 31:2393-2404
Ganesan, Lakshmi; Shieh, Peyton; Bertozzi, Carolyn R et al. (2017) Click-Chemistry Based High Throughput Screening Platform for Modulators of Ras Palmitoylation. Sci Rep 7:41147
Camarena, Vladimir; Sant, David W; Huff, Tyler C et al. (2017) cAMP signaling regulates DNA hydroxymethylation by augmenting the intracellular labile ferrous iron pool. Elife 6:
Knight, Abigail S; Kulkarni, Rishikesh U; Zhou, Effie Y et al. (2017) A modular platform to develop peptoid-based selective fluorescent metal sensors. Chem Commun (Camb) 53:3477-3480
Ackerman, Cheri M; Lee, Sumin; Chang, Christopher J (2017) Analytical Methods for Imaging Metals in Biology: From Transition Metal Metabolism to Transition Metal Signaling. Anal Chem 89:22-41
Plante, Samuel; Normant, Vincent; Ramos-Torres, Karla M et al. (2017) Cell-surface copper transporters and superoxide dismutase 1 are essential for outgrowth during fungal spore germination. J Biol Chem 292:11896-11914
Kulkarni, Rishikesh U; Kramer, Daniel J; Pourmandi, Narges et al. (2017) Voltage-sensitive rhodol with enhanced two-photon brightness. Proc Natl Acad Sci U S A 114:2813-2818
Chen, Janice S; Dagdas, Yavuz S; Kleinstiver, Benjamin P et al. (2017) Enhanced proofreading governs CRISPR-Cas9 targeting accuracy. Nature 550:407-410

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