This is the second renewal application for the Chemistry-Biology Interface predoctoral training grant at UC Berkeley. The program provides graduate PhD students with a unique depth of training in the application of chemical principles and techniques to the investigation and modulation of biological systems. The program's goal is to encourage further integration of the fields of chemistry and biology and prepare students for a future of research at this interface. Key components of the program include three first-year laboratory rotations among 39 faculty in nine different departments, specialized didactic training, seminars, annual retreat and career day, and new in this proposal, training in scientific communication and K-12 outreach. To date, the program has trained 150 students with 50 already completing their PhD degrees, 31 during the last grant cycle. Students emerging from Berkeley with this unique training are positioned to make a significant impact on human health and biomedical science in both industrial and academic settings.

Public Health Relevance

This proposal trains students to develop competence at the intersection of chemistry and biology fields. Students learn the language and techniques to manipulate biological systems at the molecular level, which is key for the design of rational means of diagnosis and treatment of pathological processes. Reciprocally, the study of biological problems leads to the development of new synthetic and mechanistic tools in the chemical sciences. Students trained in this interdisciplinary program are uniquely positioned to make new discoveries in biomedical science and craft new cures for human disease.

Agency
National Institute of Health (NIH)
Type
Institutional National Research Service Award (T32)
Project #
2T32GM066698-11
Application #
8551356
Study Section
(TWD)
Program Officer
Fabian, Miles
Project Start
Project End
Budget Start
Budget End
Support Year
11
Fiscal Year
2014
Total Cost
Indirect Cost
Name
University of California Berkeley
Department
Miscellaneous
Type
Organized Research Units
DUNS #
City
Berkeley
State
CA
Country
United States
Zip Code
94704
Hickey, Scott F; Hammond, Ming C (2014) Structure-guided design of fluorescent S-adenosylmethionine analogs for a high-throughput screen to target SAM-I riboswitch RNAs. Chem Biol 21:345-56
Obermeyer, Allie C; Jarman, John B; Francis, Matthew B (2014) N-terminal modification of proteins with o-aminophenols. J Am Chem Soc 136:9572-9
Oestreich, Kenneth J; Read, Kaitlin A; Gilbertson, Sarah E et al. (2014) Bcl-6 directly represses the gene program of the glycolysis pathway. Nat Immunol 15:957-64
Wilson, Stephen C; Cohen, Daniel T; Wang, Xin C et al. (2014) A neutral pH thermal hydrolysis method for quantification of structured RNAs. RNA 20:1153-60
Weeks, Amy M; Keddie, Neil S; Wadoux, Rudy D P et al. (2014) Molecular recognition of fluorine impacts substrate selectivity in the fluoroacetyl-CoA thioesterase FlK. Biochemistry 53:2053-63
Walker, Mark C; Chang, Michelle C Y (2014) Natural and engineered biosynthesis of fluorinated natural products. Chem Soc Rev 43:6527-36
Mackenzie, Katherine J; Francis, Matthew B (2013) Recyclable thermoresponsive polymer-cellulase bioconjugates for biomass depolymerization. J Am Chem Soc 135:293-300
Jeffrey, Jenna L; Bartlett, Emily S; Sarpong, Richmond (2013) Intramolecular C(sp3)-N coupling by oxidation of benzylic C,N-dianions. Angew Chem Int Ed Engl 52:2194-7
Knight, Abigail S; Zhou, Effie Y; Pelton, Jeffrey G et al. (2013) Selective chromium(VI) ligands identified using combinatorial peptoid libraries. J Am Chem Soc 135:17488-93
Capehart, Stacy L; Coyle, Michael P; Glasgow, Jeff E et al. (2013) Controlled integration of gold nanoparticles and organic fluorophores using synthetically modified MS2 viral capsids. J Am Chem Soc 135:3011-6

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