The School of Chemical Sciences (SCS) at Illinois seeks an additional 5 years of funding to build upon the initial success of its Chemistry- Biology Interface (CBI) Training Program. The program's objective remains the same - to further cutting-edge training at the interface of these disciplines. This will be accomplished by training a cadre of chemists, chemical and biomolecular engineers, and biologists who will share a common language and skill set and who will leave Illinois well-prepared to assume positions in a variety of settings including industry, government, and the academy. Ten trainees per year (5 2nd + 5 3rd year graduate students) would be directly supported by the funds sought from NIH. These trainees will share experiences in the classroom and at the bench. They will join a larger group of CBI trainees (approximately 30-40 at any given time) supported by their research mentors or other funds. Trainees will spend time together in CBI core courses and electives and at monthly meetings featuring trainee research presentations. They will interact with prominent guest speakers presenting CBI seminars and the keynote address at the CBI's annual symposium. Career preparation will include internships and an annual Career Day featuring Ph.D. speakers employed in various settings. More than 30 faculty drawn from the SCS'two departments - Chemistry, Chemical and Biomolecular Engineering - and from four departments in the School of Molecular and Cellular Biology - Biochemistry, Microbiology, Cell &Developmental Biology, Molecular &Integrative Physiology - comprise the current training faculty. Talented students admitted to the SCS and MCB doctoral programs will form the candidate pool for half of the available trainee positions each year. The remaining positions will be filled by a special competition among 2"""""""""""""""" and 3""""""""* year trainees nominated by CBI faculty. Doctorates are conferred by the home departments after trainees complete departmental and CBI requirements in about 5 years. Underrepresented minority students will be recruited through campus programs and through summer research opportunities funded by the CBI. Roger Adams Lab, Chemistry &Life Sciences Lab, Noyes Lab, and Institute for Genomic Biology house faculty labs, seminar rooms, and shared facilities (NMR, Mass spec, etc)

Public Health Relevance

Trainees work on projects with great public health potential - among them are research on naturally occurring antibiotics to treat infectious diseases, designing of individualized treatments for cancer, modifications of influenza and other viruses at the molecular level to render them harmless, detection/amelioration of harmful germ warfare agents like anthrax, and detection/remediation of environmental toxins/contaminants.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM070421-07
Application #
8096603
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Fabian, Miles
Project Start
2005-07-01
Project End
2015-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
7
Fiscal Year
2011
Total Cost
$353,504
Indirect Cost
Name
University of Illinois Urbana-Champaign
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
041544081
City
Champaign
State
IL
Country
United States
Zip Code
61820
Grier, William K; Iyoha, Ehiremen M; Harley, Brendan A C (2017) The influence of pore size and stiffness on tenocyte bioactivity and transcriptomic stability in collagen-GAG scaffolds. J Mech Behav Biomed Mater 65:295-305
Comi, Troy J; Neumann, Elizabeth K; Do, Thanh D et al. (2017) microMS: A Python Platform for Image-Guided Mass Spectrometry Profiling. J Am Soc Mass Spectrom 28:1919-1928
Grier, W G; Moy, A S; Harley, B A (2017) Cyclic tensile strain enhances human mesenchymal stem cell Smad 2/3 activation and tenogenic differentiation in anisotropic collagen-glycosaminoglycan scaffolds. Eur Cell Mater 33:227-239
Harris, Daniel T; Hager, Marlies V; Smith, Sheena N et al. (2017) Comparison of T Cell Activities Mediated by Human TCRs and CARs That Use the Same Recognition Domains. J Immunol :
Olivares, Philip; Ulrich, Emily C; Chekan, Jonathan R et al. (2017) Characterization of Two Late-Stage Enzymes Involved in Fosfomycin Biosynthesis in Pseudomonads. ACS Chem Biol 12:456-463
Do, Thanh D; Comi, Troy J; Dunham, Sage J B et al. (2017) Single Cell Profiling Using Ionic Liquid Matrix-Enhanced Secondary Ion Mass Spectrometry for Neuronal Cell Type Differentiation. Anal Chem 89:3078-3086
Burkhart, Brandon J; Kakkar, Nidhi; Hudson, Graham A et al. (2017) Chimeric Leader Peptides for the Generation of Non-Natural Hybrid RiPP Products. ACS Cent Sci 3:629-638
Bravo Cruz, Ariana G; Han, Aiguo; Roy, Edward J et al. (2017) Deletion of the K1L Gene Results in a Vaccinia Virus That Is Less Pathogenic Due to Muted Innate Immune Responses, yet Still Elicits Protective Immunity. J Virol 91:
Richter, Michelle F; Drown, Bryon S; Riley, Andrew P et al. (2017) Predictive compound accumulation rules yield a broad-spectrum antibiotic. Nature 545:299-304
Biswas, Subhanip; Garcia De Gonzalo, Chantal V; Repka, Lindsay M et al. (2017) Structure-Activity Relationships of the S-Linked Glycocin Sublancin. ACS Chem Biol 12:2965-2969

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