The School of Chemical Sciences (SCS) at Illinois seeks an additional 5 years of funding to build upon the initial success of its Chemistry- Biology Interface (CBI) Training Program. The program's objective remains the same - to further cutting-edge training at the interface of these disciplines. This will be accomplished by training a cadre of chemists, chemical and biomolecular engineers, and biologists who will share a common language and skill set and who will leave Illinois well-prepared to assume positions in a variety of settings including industry, government, and the academy. Ten trainees per year (5 2nd + 5 3rd year graduate students) would be directly supported by the funds sought from NIH. These trainees will share experiences in the classroom and at the bench. They will join a larger group of CBI trainees (approximately 30-40 at any given time) supported by their research mentors or other funds. Trainees will spend time together in CBI core courses and electives and at monthly meetings featuring trainee research presentations. They will interact with prominent guest speakers presenting CBI seminars and the keynote address at the CBI's annual symposium. Career preparation will include internships and an annual Career Day featuring Ph.D. speakers employed in various settings. More than 30 faculty drawn from the SCS'two departments - Chemistry, Chemical and Biomolecular Engineering - and from four departments in the School of Molecular and Cellular Biology - Biochemistry, Microbiology, Cell &Developmental Biology, Molecular &Integrative Physiology - comprise the current training faculty. Talented students admitted to the SCS and MCB doctoral programs will form the candidate pool for half of the available trainee positions each year. The remaining positions will be filled by a special competition among 2"""""""""""""""" and 3""""""""* year trainees nominated by CBI faculty. Doctorates are conferred by the home departments after trainees complete departmental and CBI requirements in about 5 years. Underrepresented minority students will be recruited through campus programs and through summer research opportunities funded by the CBI. Roger Adams Lab, Chemistry &Life Sciences Lab, Noyes Lab, and Institute for Genomic Biology house faculty labs, seminar rooms, and shared facilities (NMR, Mass spec, etc)

Public Health Relevance

Trainees work on projects with great public health potential - among them are research on naturally occurring antibiotics to treat infectious diseases, designing of individualized treatments for cancer, modifications of influenza and other viruses at the molecular level to render them harmless, detection/amelioration of harmful germ warfare agents like anthrax, and detection/remediation of environmental toxins/contaminants.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM070421-07
Application #
8096603
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Fabian, Miles
Project Start
2005-07-01
Project End
2015-06-30
Budget Start
2011-07-01
Budget End
2012-06-30
Support Year
7
Fiscal Year
2011
Total Cost
$353,504
Indirect Cost
Name
University of Illinois Urbana-Champaign
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
041544081
City
Champaign
State
IL
Country
United States
Zip Code
61820
Bangru, Sushant; Arif, Waqar; Seimetz, Joseph et al. (2018) Alternative splicing rewires Hippo signaling pathway in hepatocytes to promote liver regeneration. Nat Struct Mol Biol 25:928-939
Hegemann, Julian D; Schwalen, Christopher J; Mitchell, Douglas A et al. (2018) Elucidation of the roles of conserved residues in the biosynthesis of the lasso peptide paeninodin. Chem Commun (Camb) 54:9007-9010
Clemons, Nathan C; Bannai, Yuka; Haywood, Elizabeth E et al. (2018) Cytosolic delivery of multi-domain cargos by the N-terminus of Pasteurella multocida toxin. Infect Immun :
Do, Thanh D; Ellis, Joseph F; Neumann, Elizabeth K et al. (2018) Optically Guided Single Cell Mass Spectrometry of Rat Dorsal Root Ganglia to Profile Lipids, Peptides and Proteins. Chemphyschem 19:1180-1191
Harris, Daniel T; Hager, Marlies V; Smith, Sheena N et al. (2018) Comparison of T Cell Activities Mediated by Human TCRs and CARs That Use the Same Recognition Domains. J Immunol 200:1088-1100
Svec, Riley L; Furiassi, Lucia; Skibinski, Christine G et al. (2018) Tunable Stability of Imidazotetrazines Leads to a Potent Compound for Glioblastoma. ACS Chem Biol 13:3206-3216
Schwalen, Christopher J; Hudson, Graham A; Kille, Bryce et al. (2018) Bioinformatic Expansion and Discovery of Thiopeptide Antibiotics. J Am Chem Soc 140:9494-9501
Haywood, Elizabeth E; Ho, Mengfei; Wilson, Brenda A (2018) Modular domain swapping among the bacterial cytotoxic necrotizing factor (CNF) family for efficient cargo delivery into mammalian cells. J Biol Chem 293:3860-3870
Welle, Theresa M; Alanis, Kristen; Colombo, Michelle L et al. (2018) A high spatiotemporal study of somatic exocytosis with scanning electrochemical microscopy and nanoITIES electrodes. Chem Sci 9:4937-4941
Peh, Jessie; Boudreau, Matthew W; Smith, Hannah M et al. (2018) Overcoming Resistance to Targeted Anticancer Therapies through Small-Molecule-Mediated MEK Degradation. Cell Chem Biol 25:996-1005.e4

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