This is a proposal to establish an institutional NRSA training program for predoctoral trainees in the Departments of Biological Sciences and Chemistry and Biochemistry at the University of Notre Dame. The purpose of this program is to train a highly qualified group of predoctoral students in an interdisciplinary environment that will provide them with significant cross-training at the interface of chemistry, biochemistry, and biology. The long term goals of this program are to prepare our trainees to be able to conduct independent interdisciplinary biomedical research, to work effectively in an interdisciplinary team setting, and to train others in interdisciplinary research. We also aim to foster a greater level of interaction and collaboration between biologists, biochemists, and chemists. The characteristics of our research training program include the following: A large applicant pool of highly qualified candidates A strong record of interactions and collaborations between participating laboratories A diverse and strong group of experienced, productive, and federally-funded investigators available to serve as research mentors Laboratory rotations for students prior to selection of a thesis mentor An extended cross-training experience outside the mentor's laboratory Supplementation of training with seminars, lecture series, monthly trainee meetings, and an annual retreat Tracking of each trainee's progress towards their research training goals by an individual advisory committee and by the program's steering committee Mechanisms for continuous evaluation and improvement of the training program, professional development, career placement, and attraction and retention of underrepresented minorities Excellent research facilities equipped with state-of-the-art instrumentation Strong institutional commitment, with the University of Notre Dame providing a fellowship match in a 1:1 ratio and stipend supplementation of trainees ? ? ?

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Institutional National Research Service Award (T32)
Project #
1T32GM075762-01A1
Application #
7232171
Study Section
National Institute of General Medical Sciences Initial Review Group (BRT)
Program Officer
Rogers, Michael E
Project Start
2007-07-01
Project End
2012-06-30
Budget Start
2007-07-01
Budget End
2008-06-30
Support Year
1
Fiscal Year
2007
Total Cost
$86,588
Indirect Cost
Name
University of Notre Dame
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
824910376
City
Notre Dame
State
IN
Country
United States
Zip Code
46556
Kane, Trevor L; Carothers, Katelyn E; Lee, Shaun W (2018) Virulence Factor Targeting of the Bacterial Pathogen Staphylococcus aureus for Vaccine and Therapeutics. Curr Drug Targets 19:111-127
Dik, David A; Fisher, Jed F; Mobashery, Shahriar (2018) Cell-Wall Recycling of the Gram-Negative Bacteria and the Nexus to Antibiotic Resistance. Chem Rev 118:5952-5984
Dodge, Greg J; Ronnow, Danialle; Taylor, Richard E et al. (2018) Molecular Basis for Olefin Rearrangement in the Gephyronic Acid Polyketide Synthase. ACS Chem Biol 13:2699-2707
Frederick, Thomas E; Peng, Jeffrey W (2018) A gratuitous ?-Lactamase inducer uncovers hidden active site dynamics of the Staphylococcus aureus BlaR1 sensor domain. PLoS One 13:e0197241
Rosales, Anthony R; Quinn, Taylor R; Wahlers, Jessica et al. (2018) Application of Q2MM to predictions in stereoselective synthesis. Chem Commun (Camb) 54:8294-8311
Lee, Mijoon; Batuecas, MarĂ­a T; Tomoshige, Shusuke et al. (2018) Exolytic and endolytic turnover of peptidoglycan by lytic transglycosylase Slt of Pseudomonas aeruginosa. Proc Natl Acad Sci U S A 115:4393-4398
Bouchard, Jill J; Xia, Junchao; Case, David A et al. (2018) Enhanced Sampling of Interdomain Motion Using Map-Restrained Langevin Dynamics and NMR: Application to Pin1. J Mol Biol 430:2164-2180
Tomoshige, Shusuke; Dik, David A; Akabane-Nakata, Masaaki et al. (2018) Total Syntheses of Bulgecins A, B, and C and Their Bactericidal Potentiation of the ?-Lactam Antibiotics. ACS Infect Dis 4:860-867
Shaw, Scott K; Schreiber, Cynthia L; Roland, Felicia M et al. (2018) High expression of integrin ?v?3 enables uptake of targeted fluorescent probes into ovarian cancer cells and tumors. Bioorg Med Chem 26:2085-2091
Nguyen, Trung T; Ding, Derong; Wolter, William R et al. (2018) Expression of active matrix metalloproteinase-9 as a likely contributor to the clinical failure of aclerastide in treatment of diabetic foot ulcers. Eur J Pharmacol 834:77-83

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