Modern anesthesiology and pain medicine have increasingly become an interdisciplinary specialty of medicine that requires integrated knowledge in anesthesiology, critical care medicine, neurobiology, pharmacology, structural and computational biology, pulmonary physiology, and molecular biology and genetics. This competitive renewal application seeks funding for years 6-10 of our successful T32 training program in postgraduate anesthesia research training at the University of Pittsburgh. Our primary goal is to continue training physician scientists to lead the future intellectual pursuits n anesthesiology beyond the confines of the traditional provision of anesthesia and to become independently funded investigators and leaders in the field. The trainees from our first funding cycle have demonstrated success in this path, producing numerous peer-reviewed publications, achieving seed and startup grant funding, and presenting at scientific conferences. We propose to train four fellows in years 6-7 and five in years 8-10. A team of 33 principal training faculty,all with excellent training records and successful research programs funded by the NIH and other agencies, have been carefully selected. Programmed training and research activities will target anesthesiology-related problems defined in the broadest sense. A minimum of two-years of training is planned using a combination of structured didactic and interactive teaching on both a group and individual basis as well as one-on-one mentoring in laboratory/clinical research. Multiple courses and online training sessions in research integrity are mandatory for all trainees. Departmental, institutional, and independent efforts are established to actively recruit underrepresented minority trainees into the program. The administrative infrastructure consists of the Oversight Committee chaired by the Chairman of the Department of Anesthesiology and the Executive Committee chaired by the Program Director. The executive committee, working closely with the training faculty, will be in charge of the selection, appointment, and assignment of the trainees, and will regularly review and evaluate them. Continued NIH support of this postdoctoral training program, which focuses primarily on training of physician scientists, will provide both unique opportunities and critically needed resources for the next generation of academic anesthesiologists to integrate multidisciplinary knowledge from the bench-top to the bedside.

Public Health Relevance

Close to 50 million medical procedures are performed each year that require professional care by anesthesiologists. These procedures, as well as many diseases such as cancer, are accompanied by chronic and acute pain. The very best physician scientists are needed to lead the future intellectual pursuits in anesthesiology and pain medicine and to translate research findings into improved clinical outcomes. This program aims to train academic anesthesiologists to become leaders in the anesthesia field.

National Institute of Health (NIH)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZGM1)
Program Officer
Cole, Alison E
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Pittsburgh
Schools of Medicine
United States
Zip Code
Mowrey, David D; Kinde, Monica N; Xu, Yan et al. (2015) Atomistic insights into human Cys-loop receptors by solution NMR. Biochim Biophys Acta 1848:307-14
Beckel, Jonathan M; Argall, Arthur J; Lim, Jason C et al. (2014) Mechanosensitive release of adenosine 5'-triphosphate through pannexin channels and mechanosensitive upregulation of pannexin channels in optic nerve head astrocytes: a mechanism for purinergic involvement in chronic strain. Glia 62:1486-501
Guha, Sonia; Coffey, Erin E; Lu, Wennan et al. (2014) Approaches for detecting lysosomal alkalinization and impaired degradation in fresh and cultured RPE cells: evidence for a role in retinal degenerations. Exp Eye Res 126:68-76
Ibinson, James W; Ezaru, Catalin S; Cormican, Daniel S et al. (2014) GlideScope Use improves intubation success rates: an observational study using propensity score matching. BMC Anesthesiol 14:101
Sakai, Tetsuro; Emerick, Trent D; Metro, David G et al. (2014) Facilitation of resident scholarly activity: strategy and outcome analyses using historical resident cohorts and a rank-to-match population. Anesthesiology 120:111-9
Lu, Shu Yang; Konig, Gerhardt; Yazer, Mark H et al. (2014) Stationary versus agitated storage of whole blood during acute normovolemic hemodilution. Anesth Analg 118:264-8
Konig, Gerhardt; Holmes, Allen A; Garcia, Rosario et al. (2014) In vitro evaluation of a novel system for monitoring surgical hemoglobin loss. Anesth Analg 119:595-600
Holmes, Allen A; Konig, Gerhardt; Ting, Vicki et al. (2014) Clinical evaluation of a novel system for monitoring surgical hemoglobin loss. Anesth Analg 119:588-94
Zhang, Xiulin; Beckel, Jonathan M; Daugherty, Stephanie L et al. (2014) Activation of TRPC channels contributes to OA-NO2-induced responses in guinea-pig dorsal root ganglion neurons. J Physiol 592:4297-312
Konig, Gerhardt; Hamlin, Brian R; Waters, Jonathan H (2013) Topical tranexamic acid reduces blood loss and transfusion rates in total hip and total knee arthroplasty. J Arthroplasty 28:1473-6

Showing the most recent 10 out of 26 publications