Anesthesiology's success in making the intraoperative environment an extremely safe place, an accomplishment now recognized and emulated by other specialties, should not obscure the fact that important fundamental questions about the entire perioperative experience remain unanswered. These questions pertain to 1) the mechanism of general anesthetic action, 2) physiology of the perioperative state, 3) the mechanism and prevention of postoperative delirium and cognitive dysfunction, 4) providing safety throughout the entire perioperative period, 5) improving long-term outcomes, and 6) the treatment of acute and chronic pain. However, maintaining the scientific infrastructure that will guide the field of Anesthesiology into the future requires a core of well-trained and motivated physician-scientists within the specialty who are dedicated to the pursuit of problems important to Anesthesiology. To help ensure a scientifically robust future for Anesthesiology, the Department of Anesthesiology and Critical Care Medicine (ACCM) at the Johns Hopkins University is submitting this application to support Postdoctoral Research Training in Anesthesiology. In addition to providing a critical avenue for the support of Trainees, it is anticipated that this program will continue to refine the approach whereby Johns Hopkins ACCM recruits, trains, and develops the next generation of physician-scientists in the specialty of Anesthesiology. ACCM has a long and productive history of providing training in clinical and basic Anesthesiology research, which this Training Program will continue to cultivate and formalize. Positive results are now being realized with the outstanding Trainees currently supported by the Training Program. Combined with the considerable resources already in place for faculty development at Johns Hopkins University, an Anesthesiology Post Doctoral Research Training Grant will continue to provide an outstanding opportunity for training physician-scientists to extend the scientific foundation for the practice of Anesthesiology.

Public Health Relevance

Important fundamental questions exist about anesthesia and the care of patients during and after surgery. The goal of this application is to provide support for the training of physician-scientists to address these important problems and guide the specialty of Anesthesiology into the future.

Agency
National Institute of Health (NIH)
Type
Institutional National Research Service Award (T32)
Project #
5T32GM075774-09
Application #
8677599
Study Section
Special Emphasis Panel (ZGM1)
Program Officer
Cole, Alison E
Project Start
Project End
Budget Start
Budget End
Support Year
9
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Anesthesiology
Type
Schools of Medicine
DUNS #
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Zeynalov, Emil; Rezvani, Niloofar; Miyazaki, Chikao et al. (2014) Reproductive senescence blunts response of estrogen receptor-? expression to estrogen treatment in rat post-ischemic cerebral microvessels. PLoS One 9:e102194
Yang, F; Xu, Q; Cheong, Y-K et al. (2014) Comparison of intensity-dependent inhibition of spinal wide-dynamic range neurons by dorsal column and peripheral nerve stimulation in a rat model of neuropathic pain. Eur J Pain 18:978-88
Williams, Monica; Lee, Jennifer K (2014) Intraoperative blood pressure and cerebral perfusion: strategies to clarify hemodynamic goals. Paediatr Anaesth 24:657-67
Angelini, Daniel J; Su, Qingning; Yamaji-Kegan, Kazuyo et al. (2013) Hypoxia-induced mitogenic factor (HIMF/FIZZ1/RELMýý) in chronic hypoxia- and antigen-mediated pulmonary vascular remodeling. Respir Res 14:1
Feltes, Carolyn M; Hassoun, Heitham T; Lie, Mihaela L et al. (2011) Pulmonary endothelial cell activation during experimental acute kidney injury. Shock 36:170-6
Angelini, Daniel J; Su, Qingning; Kolosova, Irina A et al. (2010) Hypoxia-induced mitogenic factor (HIMF/FIZZ1/RELM alpha) recruits bone marrow-derived cells to the murine pulmonary vasculature. PLoS One 5:e11251
Zeynalov, Emil; Shah, Zahoor A; Li, Rung-Chi et al. (2009) Heme oxygenase 1 is associated with ischemic preconditioning-induced protection against brain ischemia. Neurobiol Dis 35:264-9
Zeynalov, Emil; Dore, Sylvain (2009) Low doses of carbon monoxide protect against experimental focal brain ischemia. Neurotox Res 15:133-7
Zeynalov, Emil; Chen, Chih-Hung; Froehner, Stanley C et al. (2008) The perivascular pool of aquaporin-4 mediates the effect of osmotherapy in postischemic cerebral edema. Crit Care Med 36:2634-40