This initial submission for an institutional training grant is aimed at providing research training for postdoctoral trainees who will pursue careers related to critical care. The training program will be jointly based in the newly formed Emory Center for Critical Care and in the Department of Surgery at the Emory University School of Medicine. It will be multidisciplinary in nature, with faculty from the Departments of Surgery, Medicine, Pediatrics, and Biochemistry participating in the training program. The training program is two years of length, and all applicants must have a graduate level degree (MD, PhD or equivalent). The philosophy of this training program is translational science founded upon strong collaborations among clinicians and investigators. The program director/principal investigator is Craig Coopersmith, Professor of Surgery at Emory University and the Associate Director of the Emory Center for Critical Care. The PI/PD will interface closely with an executive committee made up of Timothy Buchman, PhD, MD (Professor of Surgery, Director Emory Center for Critical Care), Thomas Ziegler, MD (Professor of Medicine, Co-Program Director, Research Education, Training and Career Development Core, Atlanta Clinical and Translational Science Institute) and Greg Martin, MD (Associate Professor of Medicine, Associate Division Director for Critical Care, Pulmonary, Allergy and Critical Care). The program has 8 additional mentors from multiple departments, with widely varying research interests in domains related to critical care ranging from oxidative stress to acute lung injury to implementation science in the intensive care unit. The program has been designed to mimic the broad scope of critical care by giving trainees access to mentors with expertise in basic science, translational and clinical research. There are opportunities that span the entire age range of critical illness - from neonates to geriatrics. To provide a diverse set of opportunities, mentors are based at the following-types of hospitals in the Atlanta area - academic (Emory University Hospital), community (Emory University Hospital Midtown), public (Grady Memorial Hospital), federally-funded (Atlanta Veterans Affairs Medical Center), and children's (Children's Hospital of Atlanta at Egleston). Ultimately, the research training program is designed to reflect the collaborative and interdisciplinary nature of clinical critical care and to develop independent researchers dedicated to improving the outcomes of patients in the intensive care unit.
As the population ages, more and more patients are cared for in intensive care units. However, there is a growing gap between the rapidly expanding need for critical care services and both the workforce needed to take care of critically ill patients and the researchers needed to discover new insights to improve outcomes in the intensive care unit. This institutional training grant is aimed at bridging this gap by providing research training for individuals who will pursue careers related to critical care.
|Lyons, John D; Coopersmith, Craig M (2017) Pathophysiology of the Gut and the Microbiome in the Host Response. Pediatr Crit Care Med 18:S46-S49|
|Lorentz, C Adam; Liang, Zhe; Meng, Mei et al. (2017) Myosin light chain kinase knockout improves gut barrier function and confers a survival advantage in polymicrobial sepsis. Mol Med 23:|
|Fay, Katherine T; Ford, Mandy L; Coopersmith, Craig M (2017) The intestinal microenvironment in sepsis. Biochim Biophys Acta 1863:2574-2583|
|Ramonell, Kimberly M; Zhang, Wenxiao; Hadley, Annette et al. (2017) CXCR4 blockade decreases CD4+ T cell exhaustion and improves survival in a murine model of polymicrobial sepsis. PLoS One 12:e0188882|
|Klingensmith, Nathan J; Yoseph, Benyam P; Liang, Zhe et al. (2017) Epidermal Growth Factor Improves Intestinal Integrity and Survival in Murine Sepsis Following Chronic Alcohol Ingestion. Shock 47:184-192|
|Chen, Ching-Wen; Mittal, Rohit; Klingensmith, Nathan J et al. (2017) Cutting Edge: 2B4-Mediated Coinhibition of CD4+ T Cells Underlies Mortality in Experimental Sepsis. J Immunol 199:1961-1966|
|Klingensmith, Nathan J; Chen, Ching-Wen; Liang, Zhe et al. (2017) Honokiol Increases CD4+ T Cell Activation and Decreases TNF but Fails to Improve Survival Following Sepsis. Shock :|
|Meng, Mei; Klingensmith, Nathan J; Coopersmith, Craig M (2017) New insights into the gut as the driver of critical illness and organ failure. Curr Opin Crit Care 23:143-148|
|Lyons, John D; Klingensmith, Nathan J; Otani, Shunsuke et al. (2017) Sepsis reveals compartment-specific responses in intestinal proliferation and apoptosis in transgenic mice whose enterocytes re-enter the cell cycle. FASEB J 31:5507-5519|
|Yoseph, Benyam P; Klingensmith, Nathan J; Liang, Zhe et al. (2016) Mechanisms of Intestinal Barrier Dysfunction in Sepsis. Shock 46:52-9|
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