This renewal application requests continued support for our postdoctoral training program in developmental genetics at The Jackson Laboratory (TJL). A primary theme of this training program, which was first funded in 1977, is use of the laboratory mouse as a model system for the study of human development, birth defects and disease. Sixteen TJL faculty members participate as mentors in this program. Research training areas include germ cell development, postimplantation embryonic development, neural and motor neuron development, epilepsy models, computational and systems biology, complex trait analysis, eye development and disease, control of genome stability, the relationship between gene expression and three-dimensional chromosome structure in the nucleus, and the developmental regulation of homeostatic mechanisms. These analyses are made possible by the availability of TJL's unparalleled resource base of more than 4,100 inbred, spontaneous and genetically-engineered mutant mice. Support is requested for three postdoctoral trainees. Trainees devote their major effort to laboratory research, but also receive training in scientific integrity, presentation skills, data analysis and grant writing. Trainees participate in TJL seminars, courses, workshops, and research interest groups. They are required to write fellowship applications, and present their results both at in-house interest groups and at national and international meetings. Their progress is overseen by a formal Training Committee, which evaluates new candidates for the program and monitors progress of the trainees annually. Each member of the Training Committee also acts as an informal mentor, or liaison, for several postdoctoral trainees at TJL. Upon completion of training, program participants are qualified to engage in creative, independent research in developmental genetics at a university, research institution, or in industry.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Institutional National Research Service Award (T32)
Project #
5T32HD007065-35
Application #
8658113
Study Section
Special Emphasis Panel (ZHD1-DSR-Z (GT))
Program Officer
Coulombe, James N
Project Start
1977-07-01
Project End
2015-04-30
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
35
Fiscal Year
2014
Total Cost
$121,256
Indirect Cost
$9,676
Name
Jackson Laboratory
Department
Type
DUNS #
042140483
City
Bar Harbor
State
ME
Country
United States
Zip Code
04609
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Williams, Pete A; Harder, Jeffrey M; John, Simon W M (2017) Glaucoma as a Metabolic Optic Neuropathy: Making the Case for Nicotinamide Treatment in Glaucoma. J Glaucoma 26:1161-1168
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Sun, Fengyun; Fujiwara, Yasuhiro; Reinholdt, Laura G et al. (2015) Nuclear localization of PRDM9 and its role in meiotic chromatin modifications and homologous synapsis. Chromosoma 124:397-415
Baker, Christopher L; Kajita, Shimpei; Walker, Michael et al. (2015) PRDM9 drives evolutionary erosion of hotspots in Mus musculus through haplotype-specific initiation of meiotic recombination. PLoS Genet 11:e1004916

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