The UCSD Training Program in Reproductive Sciences takes a multidisciplinary approach to the training of postdoctoral scholars as physician-scientists and basic scientists in the field of neuroendocrine and endocrine control of reproductive processes. Three fellows are supported in two categories: those seeking advanced basic research experience after the Ph.D. or M.D. degree, and those seeking clinical and research training with the aim of becoming board-certified in Reproductive Endocrinology after residency in ob/gyn or in endocrinology after residency in medicine. A cohesive group of faculty members from the Division of Reproductive Endocrinology in the Department of Reproductive Medicine and the Division of Endocrinology in the Department of Medicine at UCSD with common interests and complimentary backgrounds provides basic and clinical training and fosters the careers of the trainees. Many of the faculty members are members of the UCSD NICHD Specialized Cooperative Centers Program in Reproductive Research and many of the senior faculty members are mentors in the NICHD Women's Reproductive Health Research Program for the training of junior faculty members in research careers. Thus, this Training Program is integrated with both NICHD Centers, allowing the teaching staff and fellows to interact at many levels, creating an atmosphere of cooperation, collaboration, and career support. Our research activities range from molecular to patient-oriented research utilizing models from in vitro analysis and cell culture, to whole animal and clinical research. Major foci of investigation include: pituitary and hypothalamic development, ovarian physiology, polycystic ovary disease, signal transduction, GnRH and gonadotropin gene expression and secretion, metabolic impact on reproductive function, activin and growth factors in reproduction, and estrogen replacement therapies. The Program of training for the fellows includes group meetings and presentations, journal clubs, clinical activity and training, laboratory training and independent research, seminars, national meetings, and course work in molecular biology, neuroendocrinology, biostatistics, and ethics.
Our aim i s to prepare physician-scientists and basic scientists to become the future leaders in academic reproductive research. The urgency and importance of producing critically needed basic, translational, and clinical scientists in the area of women's health is well recognized by the leadership of NIH, the scientific community, the national government, and the society as a whole.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Institutional National Research Service Award (T32)
Project #
5T32HD007203-28
Application #
7822903
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Taymans, Susan
Project Start
1979-07-01
Project End
2013-04-30
Budget Start
2010-05-01
Budget End
2011-04-30
Support Year
28
Fiscal Year
2010
Total Cost
$172,362
Indirect Cost
Name
University of California San Diego
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Yang, Jennifer A; Song, Christopher I; Hughes, Jessica K et al. (2017) Acute Psychosocial Stress Inhibits LH Pulsatility and Kiss1 Neuronal Activation in Female Mice. Endocrinology 158:3716-3723
Xie, Huimin; Hoffmann, Hanne M; Iyer, Anita K et al. (2017) Chromatin status and transcription factor binding to gonadotropin promoters in gonadotrope cell lines. Reprod Biol Endocrinol 15:86
Skarra, Danalea V; Hernández-Carretero, Angelina; Rivera, Alissa J et al. (2017) Hyperandrogenemia Induced by Letrozole Treatment of Pubertal Female Mice Results in Hyperinsulinemia Prior to Weight Gain and Insulin Resistance. Endocrinology 158:2988-3003
Homer, Michael V; Charo, Lindsey M; Natarajan, Loki et al. (2017) Genetic variants of age at menopause are not related to timing of ovarian failure in breast cancer survivors. Menopause 24:663-668
Homer, Michael V; Rosencrantz, Marcus A; Shayya, Rana F et al. (2017) The effect of estradiol on granulosa cell responses to FSH in women with polycystic ovary syndrome. Reprod Biol Endocrinol 15:13
Terasaka, Tomohiro; Adakama, Mary E; Li, Song et al. (2017) Reactive Oxygen Species Link Gonadotropin-Releasing Hormone Receptor Signaling Cascades in the Gonadotrope. Front Endocrinol (Lausanne) 8:286
Schoeller, Erica L; Clark, Daniel D; Dey, Sandeepa et al. (2016) Bmal1 Is Required for Normal Reproductive Behaviors in Male Mice. Endocrinology 157:4914-4929
Luo, Elena; Stephens, Shannon B Z; Chaing, Sharon et al. (2016) Corticosterone Blocks Ovarian Cyclicity and the LH Surge via Decreased Kisspeptin Neuron Activation in Female Mice. Endocrinology 157:1187-99
Kelley, Scott T; Skarra, Danalea V; Rivera, Alissa J et al. (2016) The Gut Microbiome Is Altered in a Letrozole-Induced Mouse Model of Polycystic Ovary Syndrome. PLoS One 11:e0146509
Maas, Kevin H; Chuan, Sandy; Harrison, Evan et al. (2016) Androgen responses to adrenocorticotropic hormone infusion among individual women with polycystic ovary syndrome. Fertil Steril 106:1252-1257

Showing the most recent 10 out of 97 publications