The urgency and importance of producing critically needed basic, translational, and clinical scientists in the area of women's health and reproduction is well recognized by the leadership of NIH, the scientific community, the national government, and the society as a whole. The UCSD T32 Training Program in Reproductive Sci- ences takes a unique multidisciplinary approach to the training of postdoctoral scholars as physician-scientists and reproductive biologists in neuroendocrine and endocrine control of reproductive processes. The combina- tion of clinical, physiological, and molecular approaches to reproductive biology and medicine creates an exceptional opportunity for the training of physician-scientists and basic scientists, as well-rounded reproduc- tive endocrinologists who become extraordinarily qualified for academic careers. The program supports both fellows seeking advanced basic/translational research experience after the Ph.D. and/or M.D. degree, and those seeking clinical and research training with the aim of becoming board-certified in Reproductive Endocrin- ology and continuing in academic clinical research. We have an outstanding 35-year track record as recogniz- ed by an NIH MENTOR AWARD that funded 10 years from 2003-2012 and a perfect score of 10 given by the study section for the 2013-2018 application. A cohesive group of NIH-funded faculty from the Division of Reproductive Endocrinology in the Department of Reproductive Medicine and the Division of Endocrinology in the Department of Medicine at UCSD with common interests, shared grants, joint publications, and complimen- tary backgrounds, provides basic, translational, and clinical training and fosters the careers of the trainees. The majority of the faculty are members of the recently renewed UCSD NICHD P50 National Centers for Transla- tional Research in Reproduction and Infertility (NCTRI) and mentors in the UCSD NICHD K12 Women's Reproductive Health Research Program for the training of OB/GYN junior faculty in research careers. Thus, this training program is integrated with both NICHD Centers, allowing the faculty and fellows to interact at many levels, creating an atmosphere of cooperation, collaboration, mentoring, and career support. Our research ranges from molecular to patient-oriented research utilizing models from in vitro analysis and cell culture, to whole animal and clinical research. Major foci of investigation include: gonadal, germ cell, pituitary and hypothalamic development, ovarian physiology, polycystic ovary disease, signal transduction, Kisspeptin, GnRH, and gonadotropin gene expression and secretion, metabolic impact on reproductive function, and activin and growth factors in reproduction. The program of training for the fellows includes group meetings and presentations, journal clubs, seminars, national meetings, clinical training, laboratory training, independent research, grantsmanship training, IDP, and coursework in molecular biology, neuroendocrinology, biostatistics, and ethics, and an innovative ?Thesis Committee? mentoring structure.
Our aim i s to prepare outstanding physician-scientists and basic scientists to become the future leaders in academic reproductive research.

Public Health Relevance

The UCSD Training Program in Reproductive Sciences takes a multidisciplinary approach to prepare physician-scientists and reproductive biologists to become the future leaders in academic reproductive research. Postdoctoral scholars with Ph.D. and/or M.D. degrees are trained in the fields of reproductive neuroendocrine and gonadal physiology and development through advanced basic research experiences or engaging in clinical investigation of reproductive endocrine disorders. A cohesive, highly interactive group of faculty mentors from the Division of Reproductive Endocrinology in the Department of Reproductive Medicine and the Division of Endocrinology in the Department of Medicine with common interests, shared grants, co- authored publications, and complimentary backgrounds, provides intensive basic and clinical research training and fosters the careers of outstanding postdoctoral trainees within the environment of the NIH P50 Center for Reproductive Science and Medicine at UCSD.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Institutional National Research Service Award (T32)
Project #
5T32HD007203-37
Application #
9717268
Study Section
Special Emphasis Panel (ZHD1)
Program Officer
Taymans, Susan
Project Start
1979-07-01
Project End
2023-04-30
Budget Start
2019-05-01
Budget End
2020-04-30
Support Year
37
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of California, San Diego
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
804355790
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Li, Song; Mbong, Ekaette F; John, Denise T et al. (2018) Induction of Stress Signaling In Vitro and Suppression of Gonadotropin Secretion by Free Fatty Acids in Female Mouse Gonadotropes. Endocrinology 159:1074-1087
Pandolfi, Erica C; Hoffmann, Hanne M; Schoeller, Erica L et al. (2018) Haploinsufficiency of SIX3 Abolishes Male Reproductive Behavior Through Disrupted Olfactory Development, and Impairs Female Fertility Through Disrupted GnRH Neuron Migration. Mol Neurobiol 55:8709-8727
Stephens, Shannon B Z; Di Giorgio, Noelia P; Liaw, Reanna B et al. (2018) Estradiol-Dependent and -Independent Stimulation of Kiss1 Expression in the Amygdala, BNST, and Lateral Septum of Mice. Endocrinology 159:3389-3402
Fernandez, Marina O; Hsueh, Katherine; Park, Hyun Tae et al. (2017) Astrocyte-Specific Deletion of Peroxisome-Proliferator Activated Receptor-? Impairs Glucose Metabolism and Estrous Cycling in Female Mice. J Endocr Soc 1:1332-1350
Xie, Huimin; Hoffmann, Hanne M; Iyer, Anita K et al. (2017) Chromatin status and transcription factor binding to gonadotropin promoters in gonadotrope cell lines. Reprod Biol Endocrinol 15:86
Homer, Michael V; Charo, Lindsey M; Natarajan, Loki et al. (2017) Genetic variants of age at menopause are not related to timing of ovarian failure in breast cancer survivors. Menopause 24:663-668
Yang, Jennifer A; Song, Christopher I; Hughes, Jessica K et al. (2017) Acute Psychosocial Stress Inhibits LH Pulsatility and Kiss1 Neuronal Activation in Female Mice. Endocrinology 158:3716-3723
Skarra, Danalea V; Hernández-Carretero, Angelina; Rivera, Alissa J et al. (2017) Hyperandrogenemia Induced by Letrozole Treatment of Pubertal Female Mice Results in Hyperinsulinemia Prior to Weight Gain and Insulin Resistance. Endocrinology 158:2988-3003
Shliakhtsitsava, Ksenya; Suresh, Deepika; Hadnott, Tracy et al. (2017) Best Practices in Counseling Young Female Cancer Survivors on Reproductive Health. Semin Reprod Med 35:378-389
Stephens, Shannon B Z; Kauffman, Alexander S (2017) Regulation and Possible Functions of Kisspeptin in the Medial Amygdala. Front Endocrinol (Lausanne) 8:191

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