Since the inception of the NIH T32-supported University of Washington's Pediatric Infectious Diseases Training Program in 1981, our faculty has trained 92 fellows, 5 of who will be continuing training with the support of this grant. Of the 87 former trainees, 72 (84%) are actively involved in research careers in academic positions at universities (n=58), government (n=5), or industry (n=9). Fellows who have completed training in the past 10 years have had remarkable early success in research careers, with most (n=12/16, 75%) progressing to the NIH K series of awards. Since submission of our last competitive renewal, 11 fellows have completed training in our program, including two individuals from under-represented-minorities. Nine of these 11 (82%) fellows have published one or more (a total of 31, mean 2.8) publications related to their fellowship research in peer- reviewed journals. The objective of our program is to identify and recruit committed young post-doctoral physicians and scientists interested in pediatric infectious diseases. We provide them with training in microbiology, molecular and cellular techniques, genomics, proteomics, bioinformatics, and translational strategies. Under the direction of a senior mentor with a record of successful projects supported by the NIH or foundations, each fellow leads at least one research project during our 3-year fellowship. Integrated into our program is training to perform research with human subjects and animals in compliance with all the federal regulations, grant and manuscript preparation and strategies to succeed in academia. Through our mentoring and training, we aim to propel our fellows to contribute critical insights into understanding and treating pediatric infectious diseases.

Public Health Relevance

Infectious diseases continue to contribute to most deaths in children. Academic researchers focused on infectious diseases have contributed to the elimination or control of many infections that have killed or maimed children, including small pox, polio, meningitis, measles, prevention of pediatric AIDS and diarrhea. Training individuals to continue this work is important to improving the health of the world's children.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Institutional National Research Service Award (T32)
Project #
5T32HD007233-33
Application #
8658301
Study Section
Special Emphasis Panel (ZHD1)
Program Officer
Higgins, Rosemary
Project Start
1981-07-01
Project End
2017-04-30
Budget Start
2014-05-01
Budget End
2015-04-30
Support Year
33
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Seattle Children's Hospital
Department
Type
DUNS #
City
Seattle
State
WA
Country
United States
Zip Code
98121
Kanthula, Ruth; Rossouw, Theresa M; Feucht, Ute D et al. (2017) Persistence of HIV drug resistance among South African children given nevirapine to prevent mother-to-child-transmission. AIDS 31:1143-1148
Gendrin, Claire; Shubin, Nicholas J; Boldenow, Erica et al. (2017) Mast cell chymase decreases the severity of group B Streptococcus infections. J Allergy Clin Immunol :
Gammill, H S; Harrington, W E (2017) Microchimerism: Defining and redefining the prepregnancy context - A review. Placenta 60:130-133
Vornhagen, Jay; Quach, Phoenicia; Boldenow, Erica et al. (2016) Bacterial Hyaluronidase Promotes Ascending GBS Infection and Preterm Birth. MBio 7:
Adams Waldorf, Kristina M; Stencel-Baerenwald, Jennifer E; Kapur, Raj P et al. (2016) Fetal brain lesions after subcutaneous inoculation of Zika virus in a pregnant nonhuman primate. Nat Med 22:1256-1259
Boldenow, Erica; Gendrin, Claire; Ngo, Lisa et al. (2016) Group B Streptococcus circumvents neutrophils and neutrophil extracellular traps during amniotic cavity invasion and preterm labor. Sci Immunol 1:
Levitte, Steven; Adams, Kristin N; Berg, Russell D et al. (2016) Mycobacterial Acid Tolerance Enables Phagolysosomal Survival and Establishment of Tuberculous Infection In Vivo. Cell Host Microbe 20:250-8
Harrington, Whitney E; Fried, Michal; Duffy, Patrick E (2016) Defending the Use of Sulfadoxine-Pyrimethamine for Intermittent Preventive Treatment for Malaria in Pregnancy: A Short-Sighted Strategy. J Infect Dis 213:496-7
Gendrin, Claire; Vornhagen, Jay; Ngo, Lisa et al. (2015) Mast cell degranulation by a hemolytic lipid toxin decreases GBS colonization and infection. Sci Adv 1:e1400225
Whidbey, Christopher; Vornhagen, Jay; Gendrin, Claire et al. (2015) A streptococcal lipid toxin induces membrane permeabilization and pyroptosis leading to fetal injury. EMBO Mol Med 7:488-505

Showing the most recent 10 out of 59 publications