This Training Program prepares physicians and scientists for investigative careers in reproductive biology. During its 30 year history, the program has trained 90 postdoctoral fellows and graduate students who have gone on to successful careers in academia and industry. The program is multifaceted and broadly based. Research training is provided by 23 members of the Center for Reproductive Sciences (CRS) who hold faculty positions in 8 departments and organized research units. The Faculty have a broad range of scientific expertise and activities in reproductive biology, including: stem cell biology, germ cell development, meiosis, follicular maturation, mechanisms of hormone action;molecular genetics, steroid biosynthesis and action, endometrial and placental function, endocrine regulation of normal and abnormal reproductive function, basic and clinical studies of PCOS. Technologies available include: human and mouse embryology, embryonic and induced pluripotent stem cells, transgenic mice, drosophila stem and germ cell development, yeast models of meiosis, human genetics and genomics, state-of-the-art DNA and RNA sequencing, protein/nucleic acid interaction technologies, microarrays and proteomics, bioinformatics, mass spectrometric analysis of proteins and small molecules, cutting edge microscopy and imaging technologies, in vitro fertilization, whole animal physiology, prospective clinical investigation. Following formal application to the CRS (postdoctoral fellows) or to an appropriate graduate program (predoctoral fellows), trainees are selected by an Admissions Committee. Graduate students pursue a course of study leading to the Ph.D. degree. Postdoctoral training will be offered to Ph.D. fellows in related disciplines, and to clinically trained M.D. scientists with prior specialty training. In addition to their research work, trainees take prescribed academic courses, seminars, journal clubs, conferences, and seminars on the responsible conduct of research. Trainees learn to design and execute basic research projects, analyze data and write manuscripts for prominent peer-reviewed journals. Trainees prepare and submit grant applications for extra-mural funding, present seminars in reproductive biology, and learn how to mentor students working in the lab during the summer, preparing them for independent academic careers. Trainee academic development is assured by mentoring committees through individual development plans;success of trainees and the training program is tracked through surveys of alumni. The strengths of the program include 1.) the diverse skills and interests of the faculty, 2.) the interactiveness of the faculty 3.) our substantial laboratory and core facility resources 4.) the outstanding environment for research in reproduction, development, endocrinology, cell biology, genetics and related areas at UCSF and 5.) the commitment to the highest standard of conduct in science.
Human reproduction affects all generations, yet many questions remain concerning both the basic biology and clinical issues in women's health. This program integrates faculty in basic science and clinical investigation and seeks to train investigators to study both basic and clinical human reproductive biology to improve the health of women and children.
|Feuer, Sky; Rinaudo, Paolo (2016) From Embryos to Adults: A DOHaD Perspective on In Vitro Fertilization and Other Assisted Reproductive Technologies. Healthcare (Basel) 4:|
|Cakmak, Hakan; Franciosi, Federica; Zamah, A Musa et al. (2016) Dynamic secretion during meiotic reentry integrates the function of the oocyte and cumulus cells. Proc Natl Acad Sci U S A 113:2424-9|
|Bayless, Daniel W; Shah, Nirao M (2016) Genetic dissection of neural circuits underlying sexually dimorphic social behaviours. Philos Trans R Soc Lond B Biol Sci 371:20150109|
|Parchem, Ronald J; Moore, Nicole; Fish, Jennifer L et al. (2015) miR-302 Is Required for Timing of Neural Differentiation, Neural Tube Closure, and Embryonic Viability. Cell Rep 12:760-73|
|Faire, Mehlika; Skillern, Amanda; Arora, Ripla et al. (2015) Follicle dynamics and global organization in the intact mouse ovary. Dev Biol 403:69-79|
|Parchem, Ronald J; Ye, Julia; Judson, Robert L et al. (2014) Two miRNA clusters reveal alternative paths in late-stage reprogramming. Cell Stem Cell 14:617-31|
|Chen, Joseph C; Erikson, David W; Piltonen, Terhi T et al. (2013) Coculturing human endometrial epithelial cells and stromal fibroblasts alters cell-specific gene expression and cytokine production. Fertil Steril 100:1132-43|
|Cakmak, Hakan; Fujimoto, Victor Y; Zamah, A Musa et al. (2012) Metaphase II (MII) oocytes obtained at different time points in the same in vitro fertilization cycle. J Assist Reprod Genet 29:1203-5|
|Lamb, Julie D; Zamah, A Musa; Shen, Shehua et al. (2010) Follicular fluid steroid hormone levels are associated with fertilization outcome after intracytoplasmic sperm injection. Fertil Steril 94:952-7|
|Babiarz, Joshua E; Ruby, J Graham; Wang, Yangming et al. (2008) Mouse ES cells express endogenous shRNAs, siRNAs, and other Microprocessor-independent, Dicer-dependent small RNAs. Genes Dev 22:2773-85|
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