This Institutional training grant is for training in the field of behavior genetics. The goals of behavior genetics are to elucidate the genetic and environmental components that regulate the development of individual differences in normal and abnormal behavior. Using multidisciplinary approaches, the genetic basis of human development and susceptibility to psychopathology and disease, can be investigated. The application of biometrical, statistical, and quantitative genetic techniques and the development of quantitative trait loci methods allow the mapping and identification of genes that regulate complex traits. Information from such analyses, along with neurochemical, neuropharmacologlcal, neurophysiologlcal, and molecular genetic studies, will provide an understanding of gene function related to health and behavior. The Institute for Behavioral Genetics (IBG) at the University of Colorado has actively pursued the goals of behavior genetics for over 40 years. Its faculty is distinguished and active in research. Major research projects are now in progress in both human and animal behavior genetics, including large scale national collaborative studies amassing DNA repositories and rich phenotypic data sets for studies of behavioral development and mental health. Facilities are available for genotype assay, including genome-wide assays, gene function and expression studies, and behavioral, biochemical, and neurophysiologlcal studies. Funds are requested to support 5 predoctoral and 1 postdoctoral trainee over a total period of 5 years. Predoctoral trainees receive doctorate degrees from a cooperating academic unit and certification in behavior genetics. Academic requirements in the training program include training in behavior genetics, quantitative and biometrical genetics, theoretical and computer-based statistics, molecular genetics, bioinformatics and genomics, responsible conduct of research, and courses on behavioral and clinical phenotypes. Additional requirements vary according to the degree granting academic unit. Research experience is an integral part of training. Postdoctoral trainees also pursue a formalized program that emphasizes individual research as well as competence in molecular and quantitative behavior genetics. Other activities In preparation for research careers in biobehavioral development Include: supervision of students and/or technicians, hosting of seminar speakers, guest lecturing, a weekly journal club, and mandatory attendance In a course on the responsible conduct of research.
This proposal is to train scientists who will be able to contribute significantly to our understanding of genetic contributions to human development and health. A better understanding of human developmental processes and susceptibility to developmental disorders and disease will contribute to the development and application of primary prevention and early intervention techniques to improve health and optimal development.
|Daw, Jonathan; Boardman, Jason D; Peterson, Rachel et al. (2014) The interactive effect of neighborhood peer cigarette use and 5HTTLPR genotype on individual cigarette use. Addict Behav 39:1804-10|
|Simonson, Matthew A; McQueen, Matthew B; Keller, Matthew C (2014) Whole-genome pathway analysis on 132,497 individuals identifies novel gene-sets associated with body mass index. PLoS One 9:e78546|
|Johnson, Daniel P; Whisman, Mark A; Corley, Robin P et al. (2014) Genetic and environmental influences on rumination and its covariation with depression. Cogn Emot 28:1270-86|
|Whisman, Mark A; Johnson, Daniel P; Rhee, Soo Hyun (2014) A Behavior Genetic Analysis of Pleasant Events, Depressive Symptoms, and Their Covariation. Clin Psychol Sci 2:535-544|
|Whisman, Mark A; Rhee, Soo Hyun; Hink, Laura et al. (2014) Genetic and Environmental Influences on the Association between Subjective Well-Being and Marital Adjustment. Couple Family Psychol 3:48-64|
|Smith Watts, Ashley K; Patel, Deepika; Corley, Robin P et al. (2014) Testing alternative hypotheses regarding the association between behavioral inhibition and language development in toddlerhood. Child Dev 85:1569-85|
|Daw, Jonathan; Boardman, Jason D (2014) The long arm of adolescence: school health behavioral environments, tobacco and alcohol co-use, and the 5HTTLPR gene. Biodemography Soc Biol 60:117-36|
|Daw, Jonathan (2014) Of kin and kidneys: do kinship networks contribute to racial disparities in living donor kidney transplantation? Soc Sci Med 104:42-7|
|Wills, Amanda G; Carey, Gregory (2013) Adolescent peer choice and cigarette smoking: evidence of active gene-environment correlation? Twin Res Hum Genet 16:970-6|
|Johnson, Daniel P; Whisman, Mark A (2013) Gender differences in rumination: A meta-analysis. Pers Individ Dif 55:367-374|
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