This application is to renew funding of a Developmental Biology graduate training program. Funds are requested for 9 predoctoral positions, within a developmental biology research program that includes approximately 66 graduate students and 47 postdoctoral trainees. Over the past year we have added three new faculty working on developmental biology of the mouse ~ a new research area for our program -- as well as adding three faculty trainers in the area of evolution/development. These changes add new strengths and breadth to our core developmental biology training program. Our training program emphasizes individualized graduate research training within a group of interactive faculty that provides each student with diverse training input, and a number of students have co-advisors allowing them to integrate research training from two laboratories. Each predoctoral student is advised by a faculty committee that guides the student through a highly individualized training program;the committee meets at least once every year, in addition to many informal meetings (e.g. journal clubs and research seminars), resulting in excellent monitoring of the student's progress and the creation of a supportive environment. Twenty training faculty directly participate in the program. Faculty are all members in the Institute of Molecular Biology (10), the Institute of Neuroscience (7), or the Department of Biology (3). The University of Oregon's research Institutes provide an interactive research environment;they bring together labs with common interests, run graduate programs, provide space and funding support, and have annual retreats. Institutes also support shared research facilities - such as the Genomics and Proteomics Center, Transgenic Mouse Facility, Monoclonal Antibody Facility, and Bio-Optic Center - all staffed with expert personnel who are available to the students for training and assistance in experimental design. The Institute of Molecular Biology and Institute of Neuroscience together provide an interdisciplinary approach to developmental biology that includes computational biology, structural biology, cell biology, neuroscience, and evolutionary biology. This breadth of training combines well with the highly focused project-oriented research training the students receive in their host laboratories, producing creative scientists who will be able to develop their own first-rate research programs, thereby strengthening the national resource in developmental biology.

Public Health Relevance

Training in Developmental Biology is essential to understand the mechanisms that go awry in many diseases, including a number of devastating birth defects} such as lissencephaly. Many adult onset diseases, such as numerous cancers, appear to be due to developmental programs that are inappropriately expressed in the adult. The best way to understand, and thus design treatments, for these diseases is to train basic and clinical scientists in developmental biology.

Agency
National Institute of Health (NIH)
Institute
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Type
Institutional National Research Service Award (T32)
Project #
5T32HD007348-24
Application #
8267663
Study Section
Pediatrics Subcommittee (CHHD)
Program Officer
Henken, Deborah B
Project Start
1989-05-13
Project End
2014-04-30
Budget Start
2012-05-01
Budget End
2013-04-30
Support Year
24
Fiscal Year
2012
Total Cost
$300,565
Indirect Cost
$14,970
Name
University of Oregon
Department
Neurosciences
Type
Schools of Arts and Sciences
DUNS #
948117312
City
Eugene
State
OR
Country
United States
Zip Code
97403
Joy, Tasha; Hirono, Keiko; Doe, Chris Q (2015) The RanGEF Bj1 promotes prospero nuclear export and neuroblast self-renewal. Dev Neurobiol 75:485-93
Stewart, Scott; Gomez, Alan W; Armstrong, Benjamin E et al. (2014) Sequential and opposing activities of Wnt and BMP coordinate zebrafish bone regeneration. Cell Rep 6:482-98
Easley-Neal, Courtney; Fierro Jr, Javier; Buchanan, JoAnn et al. (2013) Late recruitment of synapsin to nascent synapses is regulated by Cdk5. Cell Rep 3:1199-212
Kniss, Jonathan S; Holbrook, Scott; Herman, Tory G (2013) R7 photoreceptor axon growth is temporally controlled by the transcription factor Ttk69, which inhibits growth in part by promoting transforming growth factor-?/activin signaling. J Neurosci 33:1509-20
Carney, Travis D; Miller, Michael R; Robinson, Kristin J et al. (2012) Functional genomics identifies neural stem cell sub-type expression profiles and genes regulating neuroblast homeostasis. Dev Biol 361:137-46
Winbush, Ari; Weeks, Janis C (2011) Steroid-triggered, cell-autonomous death of a Drosophila motoneuron during metamorphosis. Neural Dev 6:15
Atwood, Scott X; Prehoda, Kenneth E (2009) aPKC phosphorylates Miranda to polarize fate determinants during neuroblast asymmetric cell division. Curr Biol 19:723-9
Chabu, Chiswili; Doe, Chris Q (2009) Twins/PP2A regulates aPKC to control neuroblast cell polarity and self-renewal. Dev Biol 330:399-405
Atwood, Scott X; Chabu, Chiswili; Penkert, Rhiannon R et al. (2007) Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6 aPKC. J Cell Sci 120:3200-6
Miller, Craig T; Swartz, Mary E; Khuu, Patricia A et al. (2007) mef2ca is required in cranial neural crest to effect Endothelin1 signaling in zebrafish. Dev Biol 308:144-57

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