The long term goals of this T32 post-doctoral Training Program are twofold: 1). To recruit the best and brightest young physicians and basic science trainees interested in successful academic careers in biomedical research operating at the translational interface between bench and bedside using the contemporary tools of Reproduction, Development, and Genetics;and 2). To provide these high quality trainees with a secure period of stable funding so they can be exposed to: a) a rich spectrum of competitively funded and challenging biomedical problems;b) the most contemporary tools with which to attack them;c) optimal didactic experiences;and d) carefully mentored research experiences during periods of increasing autonomy. Taken together, this tight matrix of interwoven experiences equips our trainees with the foundational experiences necessary to achieve independence in research as is attested to by this program's track record of previous trainees. The key elements of success in meeting these goals are a rich pool of talented applicants and an exciting context within an Academic Medical Center. Our parent institution, the Massachusetts General Hospital (MGH), has a strong focus on human disease/disease models with a rich tradition of inter-disciplinary collaboration across a broad mix of talented training faculty (Tables 1 &2). Each faculty member has been carefully selected by the Program Directors (PDs) on the basis of their demonstrated commitment to the independence of their trainees, exciting and important biologic problems on which to work, and stable funding. The spectrum of our program's planned research projects occurs in the laboratories of 11 mid- and senior level faculty members (Tables 1-4), each focused on key questions in human development, reproduction, systems and molecular biology, and/or genetics. Our Training Program taps into an exciting blend of basic and clinical researchers who have chosen to focus their interdisciplinary skills on human disease targets, i.e. the genetics of Mendelian development disorders like Isolated GnRH Deficiency, fetal congenital lung and diaphragmatic anomalies, neurologic disorders, as well as complex genetic disorders such as polycystic ovarian syndrome (PCOS). Given our nation's pressing need and expressed priorities for training translational researchers pointed out by the Institute of Medicine's Clinical Research Roundtable (References Cited: 1 &2) as well as the powerful synergies emerging in reproduction, development and genetics, we propose to continue our current level of training 4 physicians and/or basic scientists for the next 5 years of this competing renewal application.

Public Health Relevance

This postdoctoral training program seeks to take outstanding physicians and basic scientists who desire careers in academic medicine operating at the bedside to bench translational interface and immerse them in closely mentored research experiences and intensive didactic programs under the tutelage of a dedicated training faculty working on challenging and important biological problems. Their training experiences will focus upon the disciplines of reproductive endocrinology, developmental biology, genetics, and clinical research as the core tool kits that will enable them to investigate important biological problems in men and women. These include disorders of sexual maturation, defects causing infertility in both sexes, and reproductive failure, i.e. important reproductive disorders with significant morbidity in our society.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Institutional National Research Service Award (T32)
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Special Emphasis Panel (ZHD1-DRG-D (90))
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Taymans, Susan
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Massachusetts General Hospital
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Miraoui, Hichem; Dwyer, Andrew A; Sykiotis, Gerasimos P et al. (2013) Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism. Am J Hum Genet 92:725-43
Chew, Sheena; Balasubramanian, Ravikumar; Chan, Wai-Man et al. (2013) A novel syndrome caused by the E410K amino acid substitution in the neuronal *-tubulin isotype 3. Brain 136:522-35
Shaw, N D; Klingman, K M; Srouji, S S et al. (2012) Gonadotropin responses to estrogen-positive and -negative feedback are identical in African-American and Caucasian women. J Clin Endocrinol Metab 97:E106-9
Yang, Jasmine J; Caligioni, Claudia S; Chan, Yee-Ming et al. (2012) Uncovering novel reproductive defects in neurokinin B receptor null mice: closing the gap between mice and men. Endocrinology 153:1498-508
Balasubramanian, Ravikumar; Plummer, Lacey; Sidis, Yisrael et al. (2011) The puzzles of the prokineticin 2 pathway in human reproduction. Mol Cell Endocrinol 346:44-50
Shaw, Natalie D; Gill, Sabrina; Lavoie, Helene B et al. (2011) Persistence of sleep-associated decrease in GnRH pulse frequency in the absence of gonadal steroids. J Clin Endocrinol Metab 96:2590-5
Shaw, N D; Srouji, S S; Histed, S N et al. (2011) Differential effects of aging on estrogen negative and positive feedback. Am J Physiol Endocrinol Metab 301:E351-5
Shaw, Natalie D; Seminara, Stephanie B; Welt, Corrine K et al. (2011) Expanding the phenotype and genotype of female GnRH deficiency. J Clin Endocrinol Metab 96:E566-76
Marsh, E E; Shaw, N D; Klingman, K M et al. (2011) Estrogen levels are higher across the menstrual cycle in African-American women compared with Caucasian women. J Clin Endocrinol Metab 96:3199-206
Shaw, N D; Histed, S N; Srouji, S S et al. (2010) Estrogen negative feedback on gonadotropin secretion: evidence for a direct pituitary effect in women. J Clin Endocrinol Metab 95:1955-61

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