This proposal is a renewal of the Harvard Newborn and Developmental Diseases Training Program and represents the continuation of a well-established program that was founded in 1974 and has been NIH- sponsored since 1994. The main objectives of this Program are (1) to provide rigorous training of neonatology post resident fellows to develop the knowledge and skills to become independent and productive physician- scientists in basic and clinical investigation as academic neonatologists and, (2) to provide postdoctoral PhD fellows with an introduction to development biology as applied to newborn and developmental diseases. To stimulate interest in academic neonatology at an earlier stage of career development, this Program also supports a short-term Summer Student Research Program (8 weeks) of predoctoral students paired with post- resident fellows. Strengths of the Program include benefits derived from the integration of extensive resources of four Harvard hospitals (Children's Hospital Boston, Brigham &Women's Hospital, Beth Israel Deaconess Medical Center, and Massachusetts General Hospital) and the best research mentors spanning the entire spectrum of biomedical research from basic developmental biology, translational medicine, clinical investigation, health policy outcomes research, including the economic evaluation of clinical trials and cost- effectiveness of health care delivery. The selection of trainees is competitively based on their potential for becoming independent investigators capable of assuming leadership roles in research and clinical medicine. Each trainee's research program will be developed on an individual basis with input and guidance from the Program Director, Fellowship Director, research mentor, and Scholarship Oversight Committee, closely monitoring review of fellows'progress. This NIH Training Program provides 2 and up to 3 years of support for each post-resident trainee (to begin following the first year of clinical training) nd 1-3 years of support for each postdoctoral scientist. The Program promotes the achievement of explicit training goals, using a structured set of expectations as well as formal advising and evaluation procedures. In addition to the mentored, hands-on research experience, trainees will learn directly about the nature of high quality scientific research by structured coursework in core concepts of cell and molecular biology, epidemiology, study design, and the theory and application of statistical techniques that are commonly used in clinical research. Overall, this Program provides interdisciplinary training in basic and clinical biological investigation, integrating state-of-the- art techniques and cutting-edge science with important questions in newborn medicine and biology. This approach has been proven to equip trainees with tools to advance and move independently into successful academic careers as investigators and leaders in Neonatal-Perinatal Medicine.

Public Health Relevance

The Training Program in Newborn and Developmental Diseases provides comprehensive research training for individuals with a serious commitment to a career in biomedical research focused on diseases of the newborn. Our primary goal is to train the next generation of physician scientists and scientists to become independent researchers in academic medicine in order to better understand the pathogenesis of diseases affecting infants and to implement novel therapeutic strategies.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Institutional National Research Service Award (T32)
Project #
Application #
Study Section
Special Emphasis Panel (ZHD1-DRG-D (55))
Program Officer
Raju, Tonse N
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Children's Hospital Boston
United States
Zip Code
Mitsialis, S Alex; Kourembanas, Stella (2016) Stem cell-based therapies for the newborn lung and brain: Possibilities and challenges. Semin Perinatol 40:138-51
Morton, Sarah U; Brodsky, Dara (2016) Fetal Physiology and the Transition to Extrauterine Life. Clin Perinatol 43:395-407
Manchenkov, Tania; Pasillas, Martina P; Haddad, Gabriel G et al. (2015) Novel Genes Critical for Hypoxic Preconditioning in Zebrafish Are Regulators of Insulin and Glucose Metabolism. G3 (Bethesda) 5:1107-16
Morton, Sarah U; Joshi, Mugdha; Savic, Talia et al. (2015) Skeletal muscle microRNA and messenger RNA profiling in cofilin-2 deficient mice reveals cell cycle dysregulation hindering muscle regeneration. PLoS One 10:e0123829
Nandivada, Prathima; Chang, Melissa I; Potemkin, Alexis K et al. (2015) The natural history of cirrhosis from parenteral nutrition-associated liver disease after resolution of cholestasis with parenteral fish oil therapy. Ann Surg 261:172-9
Carlson, Sarah J; Nandivada, Prathima; Chang, Melissa I et al. (2015) The addition of medium-chain triglycerides to a purified fish oil-based diet alters inflammatory profiles in mice. Metabolism 64:274-82
Tsoyi, Konstantin; Geldart, Adriana M; Christou, Helen et al. (2015) Elk-3 is a KLF4-regulated gene that modulates the phagocytosis of bacteria by macrophages. J Leukoc Biol 97:171-80
Hang, Saiyu; Purdy, Alexandra E; Robins, William P et al. (2014) The acetate switch of an intestinal pathogen disrupts host insulin signaling and lipid metabolism. Cell Host Microbe 16:592-604
Davis, N L; Gregory, M L; Rhein, L (2014) Test-retest reliability of the infant car-seat challenge. J Perinatol 34:54-8
Leeman, Kristen T; Fillmore, Christine M; Kim, Carla F (2014) Lung stem and progenitor cells in tissue homeostasis and disease. Curr Top Dev Biol 107:207-33

Showing the most recent 10 out of 43 publications