This is a competitive renewal of a training program in Developmental Hematology in the Department of Pediatrics at Washington University School of Medicine. The program will provide pediatric physicians (MD's or MD, PhD's) with postdoctoral research experience with the long-term goal of producing independent investigators capable of making important contributions to biomedical research. The program will support one second-year (PGY-4) and one third-year fellow (PGY-5) each year. The trainees will be recruited from the Hematology-Oncology fellowship program in the Department of Pediatrics at Washington University School of Medicine. The fellowship program is comprised of three to four years of training, only two of which will be supported by the T32. The Hematology-Oncology fellowship includes many qualified applicants with backgrounds in hematology research. Trainees will participate in a formal seminar series that includes a discussion of current research in developmental hematology, along with didactic sessions in statistics, design of research, and the ethical conduct of research. Trainees may perform their postdoctoral research in a wide range of laboratories at Washington University, provided the research is relevant to the field of developmental hematology. The Program offers trainees two Pathways. In Pathway A, the emphasis is on basic science genetics/genomics experiences, a core curriculum, and a basic-science curriculum. In Pathway B, the emphasis is on clinical/translational genomic science with patient-oriented laboratory-based experiences, a core curriculum and a clinical investigation, translational medicine or genetics/genomics curriculum. Alan L. Schwartz, MD, PhD, will serve as Program Director. The continued support of this program will help to close the gap between basic developmental biologists and pediatrician clinicians.
This training program is designed to bridge the gap between clinical and basic scientists. The focus of this program is the training of physician scientists in basic and applied research relevant to the causes of hematologic diseases in children. Qualified trainees, both MD's and MD/PhD's, will be selected for their potential to assume academic positions in pediatric departments at major medical schools. The training program compliments existing programs in the Department of Pediatrics designed to enhance training in developmental biology and animal models of disease.
|Ngwube, Alexander; Hayashi, Robert J; Murray, Lisa et al. (2015) Alemtuzumab based reduced intensity transplantation for pediatric severe aplastic anemia. Pediatr Blood Cancer 62:1270-6|
|Madden, Lisa M; Ngwube, Alexander I; Shenoy, Shalini et al. (2015) Late toxicity of a novel allogeneic stem cell transplant using single fraction total body irradiation for hematologic malignancies in children. J Pediatr Hematol Oncol 37:e94-e101|
|Fields, Melanie E; Hulbert, Monica L; Chen, Ling et al. (2015) Red blood cell storage duration is not associated with clinical outcomes for acute chest syndrome in children with sickle cell disease. Transfusion 55:2714-21|
|Sengupta, Rajarshi; Barone, Amy; Marasa, Jayne et al. (2015) Novel chemical library screen identifies naturally occurring plant products that specifically disrupt glioblastoma-endothelial cell interactions. Oncotarget 6:18282-92|
|Barone, Amy; Sengupta, Rajarshi; Warrington, Nicole M et al. (2014) Combined VEGF and CXCR4 antagonism targets the GBM stem cell population and synergistically improves survival in an intracranial mouse model of glioblastoma. Oncotarget 5:9811-22|
|Schuettpelz, L G; Borgerding, J N; Christopher, M J et al. (2014) G-CSF regulates hematopoietic stem cell activity, in part, through activation of Toll-like receptor signaling. Leukemia 28:1851-60|
|Bednarski, Jeffrey J; Nickless, Andrew; Bhattacharya, Deepta et al. (2012) RAG-induced DNA double-strand breaks signal through Pim2 to promote pre-B cell survival and limit proliferation. J Exp Med 209:11-7|
|Gapud, Eric J; Dorsett, Yair; Yin, Bu et al. (2011) Ataxia telangiectasia mutated (Atm) and DNA-PKcs kinases have overlapping activities during chromosomal signal joint formation. Proc Natl Acad Sci U S A 108:2022-7|
|Druley, T E; Hayashi, R; Mansur, D B et al. (2009) Early outcomes after allogeneic hematopoietic SCT in pediatric patients with hematologic malignancies following single fraction TBI. Bone Marrow Transplant 43:307-14|
|Druley, Todd E; Vallania, Francesco L M; Wegner, Daniel J et al. (2009) Quantification of rare allelic variants from pooled genomic DNA. Nat Methods 6:263-5|
Showing the most recent 10 out of 17 publications