The purpose of the Developmental and Stem Cell Biology Training Program (DSCB) is to prepare PhD candidates for participation as active scientists in disciplines having an emphasis on developmental biology, stem cell biology and developmental genetics. To accomplish this goal, the training program provides education in core principles of development, genetics, cell biology and molecular biology. Of special importance is the preparation of critical and creative minds. In addition to didactic training, the Program provides and encourages participation in a number of seminars, journal clubs and colloquia that foster discussion, perspective and critical review of the literature. Extensive laboratory training provides each student with a special expertise in his or her chosen specialty. Finally, an interactive environment and collaborations with clinical departments fosters the movement of the discovery process to treatments that will improve the human condition.

National Institute of Health (NIH)
Eunice Kennedy Shriver National Institute of Child Health & Human Development (NICHD)
Institutional National Research Service Award (T32)
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Special Emphasis Panel (ZHD1-DRG-D (55))
Program Officer
Javois, Lorette Claire
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Duke University
Schools of Arts and Sciences
United States
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Subashi, Ergys; Cordero, Francisco J; Halvorson, Kyle G et al. (2016) Tumor location, but not H3.3K27M, significantly influences the blood-brain-barrier permeability in a genetic mouse model of pediatric high-grade glioma. J Neurooncol 126:243-51
Pilaz, Louis-Jan; McMahon, John J; Miller, Emily E et al. (2016) Prolonged Mitosis of Neural Progenitors Alters Cell Fate in the Developing Brain. Neuron 89:83-99
Cao, Jingli; Navis, Adam; Cox, Ben D et al. (2016) Single epicardial cell transcriptome sequencing identifies Caveolin 1 as an essential factor in zebrafish heart regeneration. Development 143:232-43
Jain, Rajan; Barkauskas, Christina E; Takeda, Norifumi et al. (2015) Plasticity of Hopx(+) type I alveolar cells to regenerate type II cells in the lung. Nat Commun 6:6727
Kabadi, Ami M; Thakore, Pratiksha I; Vockley, Christopher M et al. (2015) Enhanced MyoD-induced transdifferentiation to a myogenic lineage by fusion to a potent transactivation domain. ACS Synth Biol 4:689-99
Polstein, Lauren R; Perez-Pinera, Pablo; Kocak, D Dewran et al. (2015) Genome-wide specificity of DNA binding, gene regulation, and chromatin remodeling by TALE- and CRISPR/Cas9-based transcriptional activators. Genome Res 25:1158-69
Lin, Yi-Tzu; Capel, Blanche (2015) Cell fate commitment during mammalian sex determination. Curr Opin Genet Dev 32:144-52
Misuraca, Katherine L; Cordero, Francisco J; Becher, Oren J (2015) Pre-Clinical Models of Diffuse Intrinsic Pontine Glioma. Front Oncol 5:172
Farin, Alicia M; Manzo, Nicholas D; Kirsch, David G et al. (2015) Low- and high-LET radiation drives clonal expansion of lung progenitor cells in vivo. Radiat Res 183:124-32
Halvorson, Kyle G; Barton, Kelly L; Schroeder, Kristin et al. (2015) A high-throughput in vitro drug screen in a genetically engineered mouse model of diffuse intrinsic pontine glioma identifies BMS-754807 as a promising therapeutic agent. PLoS One 10:e0118926

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